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- W2083148209 abstract "HLA-B27, an immunogenetic marker that is present in 8 percent of the white population around the world, has been found to be an important risk factor for the development of a group of rheumatic disorders, the seronegative spondyloarthropathies. Our objective was to assess the possible role of HLA-B27 and the associated inflammatory disease process in the development of lone aortic regurgitation.A group of 91 patients with lone aortic regurgitation were studied by HLA typing and clinical and roentgenologic examination.The HLA-B27-associated inflammatory disease process was found to be the probable underlying cause in 15 to 20 percent of patients with lone aortic regurgitation of different degrees of severity. Furthermore, HLA-B27 was found in 88 percent of the male patients with the combination of aortic regurgitation and severe conduction system abnormalities.We suggest that this cardiac syndrome should be regarded as an HLA-B27-associated syndrome, sometimes part of ankylosing spondylitis or Reiter's disease, but just as often presenting without obvious rheumatic disease. The marker is thus an important and widely distributed risk factor not only for the development of rheumatic disease but also for acquired aortic regurgitation and sever conduction system abnormalities." @default.
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- W2083148209 date "1988-07-01" @default.
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- W2083148209 title "HLA-B27: An important genetic risk factor for lone aortic regurgitation and severe conduction system abnormalities" @default.
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- W2083148209 doi "https://doi.org/10.1016/0002-9343(88)90497-4" @default.
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