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- W2083153731 endingPage "3187" @default.
- W2083153731 startingPage "3187" @default.
- W2083153731 abstract "Synthetic cationic lipids are presently the most widely used non-viral gene carriers. Examined here is a particularly attractive cationic lipid class, triester phosphatidylcholines (PCs) exhibiting low toxicities and good transfection efficiency. Similarly to other cationic lipids, they form stable complexes (lipoplexes) with the polyanionic nucleic acids. A summary of studies on a set of ∼30 cationic PCs reveals the existence of a strong, systematic dependence of their transfection efficiency on the lipid hydrocarbon chain structure: transfection activity increases with increase of chain unsaturation from 0 to 2 double bonds per lipid and decreases with increase of chain length in the range ∼30–50 total number of chain carbon atoms. Maximum transfection was observed for ethyl phosphate PCs (EPCs) with monounsaturated 14:1 chains (total of 2 double bonds and 30 chain carbon atoms). Lipid phase behavior is known to depend strongly on the chain molecular structure and the above relationships thus substantiate a view that cationic PC phase propensities are an important determinant of their activity. Indeed, X-ray structural studies show that the rate of DNA release from lipoplexes as well as transfection activity well correlate with non-lamellar phase progressions observed in cationic PC mixtures with membrane lipids. These findings appear to be of considerable interest because, according to current views, key processes in lipid-mediated transfection such as lipoplex disassembly and DNA release within the cells are believed to take place upon cationic lipid mixing with cellular lipids." @default.
- W2083153731 created "2016-06-24" @default.
- W2083153731 creator A5022182739 @default.
- W2083153731 creator A5074169677 @default.
- W2083153731 date "2009-01-01" @default.
- W2083153731 modified "2023-10-02" @default.
- W2083153731 title "Cationic phospholipids: structure–transfection activity relationships" @default.
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- W2083153731 doi "https://doi.org/10.1039/b902027f" @default.
- W2083153731 hasPublicationYear "2009" @default.
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