Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083154088> ?p ?o ?g. }
- W2083154088 endingPage "8" @default.
- W2083154088 startingPage "2" @default.
- W2083154088 abstract "A newly developed synthetic αvβ3 integrin targeted optical probe (ITOP) has been demonstrated to target cancer cells, in vivo. Compared to the commercially available cyclic peptide c[RGDfv], this optical probe has at least 20 times better binding affinity for the αvβ3 receptor. The present in vitro study was designed to investigate the possibility of detecting early atherosclerotic plaque by using this ITOP. Experiments were performed on five Watanabe heritable hyperlipidemic rabbits and two New Zealand White rabbits for control. Our ITOP was used for detecting the presence of αvβ3 receptors in vitro. Segments of plaque accumulation from two distinct regions of ascending and descending aortas were labeled in Watanabe rabbits. The signal was found principally in the adventitia and proximal intima of the aortic vessel, corresponding directly to the expression of integrin αvβ3 as determined by antibody assay. Moreover, there was a close association between the level of labeling with the αvβ3 targeted probe and the thickness of the adventitia. This high-affinity ITOP identifies the site and extent of αvβ3 expression and correlates with adventitial thickness. Recent evidence associates αvβ3 expression with the inflammatory process in early vulnerable plaque, making this compound a promising potential biomarker for early atherosclerotic disease." @default.
- W2083154088 created "2016-06-24" @default.
- W2083154088 creator A5026647360 @default.
- W2083154088 creator A5036286176 @default.
- W2083154088 creator A5037480222 @default.
- W2083154088 creator A5041322951 @default.
- W2083154088 creator A5068888577 @default.
- W2083154088 creator A5090564896 @default.
- W2083154088 date "2009-11-07" @default.
- W2083154088 modified "2023-10-15" @default.
- W2083154088 title "High-Affinity αvβ3 Integrin Targeted Optical Probe as a New Imaging Biomarker for Early Atherosclerosis: Initial Studies in Watanabe Rabbits" @default.
- W2083154088 cites W1500081368 @default.
- W2083154088 cites W1504719360 @default.
- W2083154088 cites W1893383964 @default.
- W2083154088 cites W1981192304 @default.
- W2083154088 cites W1986083736 @default.
- W2083154088 cites W2001753204 @default.
- W2083154088 cites W2001993485 @default.
- W2083154088 cites W2011090397 @default.
- W2083154088 cites W2011192430 @default.
- W2083154088 cites W2029773366 @default.
- W2083154088 cites W2039552376 @default.
- W2083154088 cites W2049052608 @default.
- W2083154088 cites W2049816773 @default.
- W2083154088 cites W2055664309 @default.
- W2083154088 cites W2066963386 @default.
- W2083154088 cites W2071392303 @default.
- W2083154088 cites W2083403064 @default.
- W2083154088 cites W2091293179 @default.
- W2083154088 cites W2092515735 @default.
- W2083154088 cites W2096868396 @default.
- W2083154088 cites W2101681003 @default.
- W2083154088 cites W2104814850 @default.
- W2083154088 cites W2109904969 @default.
- W2083154088 cites W2112285684 @default.
- W2083154088 cites W2125638994 @default.
- W2083154088 cites W2128382419 @default.
- W2083154088 cites W2133858220 @default.
- W2083154088 cites W2134771161 @default.
- W2083154088 cites W2138129993 @default.
- W2083154088 cites W2186448008 @default.
- W2083154088 cites W2324841714 @default.
- W2083154088 cites W4300811815 @default.
- W2083154088 doi "https://doi.org/10.1007/s11307-009-0242-z" @default.
- W2083154088 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7103239" @default.
- W2083154088 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19898904" @default.
- W2083154088 hasPublicationYear "2009" @default.
- W2083154088 type Work @default.
- W2083154088 sameAs 2083154088 @default.
- W2083154088 citedByCount "14" @default.
- W2083154088 countsByYear W20831540882012 @default.
- W2083154088 countsByYear W20831540882013 @default.
- W2083154088 countsByYear W20831540882014 @default.
- W2083154088 countsByYear W20831540882015 @default.
- W2083154088 crossrefType "journal-article" @default.
- W2083154088 hasAuthorship W2083154088A5026647360 @default.
- W2083154088 hasAuthorship W2083154088A5036286176 @default.
- W2083154088 hasAuthorship W2083154088A5037480222 @default.
- W2083154088 hasAuthorship W2083154088A5041322951 @default.
- W2083154088 hasAuthorship W2083154088A5068888577 @default.
- W2083154088 hasAuthorship W2083154088A5090564896 @default.
- W2083154088 hasBestOaLocation W20831540884 @default.
- W2083154088 hasConcept C142724271 @default.
- W2083154088 hasConcept C150903083 @default.
- W2083154088 hasConcept C153911025 @default.
- W2083154088 hasConcept C170493617 @default.
- W2083154088 hasConcept C185592680 @default.
- W2083154088 hasConcept C195687474 @default.
- W2083154088 hasConcept C202751555 @default.
- W2083154088 hasConcept C207001950 @default.
- W2083154088 hasConcept C26291073 @default.
- W2083154088 hasConcept C2776716733 @default.
- W2083154088 hasConcept C2781197716 @default.
- W2083154088 hasConcept C502942594 @default.
- W2083154088 hasConcept C55493867 @default.
- W2083154088 hasConcept C71924100 @default.
- W2083154088 hasConcept C86803240 @default.
- W2083154088 hasConceptScore W2083154088C142724271 @default.
- W2083154088 hasConceptScore W2083154088C150903083 @default.
- W2083154088 hasConceptScore W2083154088C153911025 @default.
- W2083154088 hasConceptScore W2083154088C170493617 @default.
- W2083154088 hasConceptScore W2083154088C185592680 @default.
- W2083154088 hasConceptScore W2083154088C195687474 @default.
- W2083154088 hasConceptScore W2083154088C202751555 @default.
- W2083154088 hasConceptScore W2083154088C207001950 @default.
- W2083154088 hasConceptScore W2083154088C26291073 @default.
- W2083154088 hasConceptScore W2083154088C2776716733 @default.
- W2083154088 hasConceptScore W2083154088C2781197716 @default.
- W2083154088 hasConceptScore W2083154088C502942594 @default.
- W2083154088 hasConceptScore W2083154088C55493867 @default.
- W2083154088 hasConceptScore W2083154088C71924100 @default.
- W2083154088 hasConceptScore W2083154088C86803240 @default.
- W2083154088 hasIssue "1" @default.
- W2083154088 hasLocation W20831540881 @default.
- W2083154088 hasLocation W20831540882 @default.
- W2083154088 hasLocation W20831540883 @default.
- W2083154088 hasLocation W20831540884 @default.
- W2083154088 hasOpenAccess W2083154088 @default.