FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083155989> ?p ?o ?g. }

• W2083155989 endingPage "e86326" @default.
• W2083155989 startingPage "e86326" @default.
• W2083155989 abstract "Objectives Intermittent hypoxia (IH), resulted from recurring episodes of upper airway obstruction, is the hallmark feature and the most important pathophysiologic pathway of obstructive sleep apnea (OSA). IH is believed to be the most important factor causing systemic inflammation. Studies suggest that insulin resistance (IR) is positively associated with OSA. In this study, we hypothesized that the recurrence of IH might result in cellular and systemic inflammation, which was manifested through the levels of proinflammatory cytokines and adipokines after IH exposure, and because IR is linked with inflammation tightly, this inflammatory situation may implicate an IR status. Methods We developed an IH 3T3-L1 adipocyte and rat model respectively, recapitulating the nocturnal oxygen profile in OSA. In IH cells, nuclear factor kappa B (NF-κB) DNA binding reactions, hypoxia-inducible factor-1α (HIF-1α), glucose transporter-1 (Glut-1), necrosis factor alpha (TNF-α), interleukin (IL) -6, leptin, adiponectin mRNA transcriptional activities and protein expressions were measured. In IH rats, blood glucose, insulin, TNF-α, IL-6, leptin and adiponectin levels were analyzed. Results The insulin and blood glucose levels in rats and NF-κB DNA binding activities in cells had significantly statistical results described as severe IH>moderate IH>mild IH>sustained hypoxia>control. The mRNA and protein levels of HIF-1α and Glut-1 in severe IH group were the highest. In cellular and animal models, both the mRNA and protein levels of TNF-α, IL-6 and leptin were the highest in severe IH group, when the lowest in severe IH group for adiponectin. Conclusions Oxidative stress and the release of pro-inflammatory cytokines/adipokines, which are the systemic inflammatory markers, are associated with IH closely and are proportional to the severity of IH. Because IR and glucose intolerance are linked with inflammation tightly, our results may implicate the clinical relationships between OSA and IR." @default.
• W2083155989 created "2016-06-24" @default.
• W2083155989 creator A5013596240 @default.
• W2083155989 creator A5024648164 @default.
• W2083155989 creator A5033624164 @default.
• W2083155989 creator A5045492083 @default.
• W2083155989 creator A5050300826 @default.
• W2083155989 creator A5055522505 @default.
• W2083155989 creator A5061550065 @default.
• W2083155989 creator A5073655805 @default.
• W2083155989 creator A5075489258 @default.
• W2083155989 date "2014-01-21" @default.
• W2083155989 modified "2023-10-16" @default.
• W2083155989 title "Effects of Varying Degrees of Intermittent Hypoxia on Proinflammatory Cytokines and Adipokines in Rats and 3T3-L1 Adipocytes" @default.
• W2083155989 cites W1480885089 @default.
• W2083155989 cites W1485905810 @default.
• W2083155989 cites W195820962 @default.
• W2083155989 cites W1964800288 @default.
• W2083155989 cites W1966475752 @default.
• W2083155989 cites W1967964480 @default.
• W2083155989 cites W1970066295 @default.
• W2083155989 cites W1972155258 @default.
• W2083155989 cites W1973619189 @default.
• W2083155989 cites W1974599416 @default.
• W2083155989 cites W1987293505 @default.
• W2083155989 cites W1988172841 @default.
• W2083155989 cites W1990251709 @default.
• W2083155989 cites W1990604266 @default.
• W2083155989 cites W1991346678 @default.
• W2083155989 cites W1998009398 @default.
• W2083155989 cites W2010474125 @default.
• W2083155989 cites W2011210301 @default.
• W2083155989 cites W2024431022 @default.
• W2083155989 cites W2027358194 @default.
• W2083155989 cites W2033094833 @default.
• W2083155989 cites W2036849525 @default.
• W2083155989 cites W2037278919 @default.
• W2083155989 cites W2037610000 @default.
• W2083155989 cites W2038265231 @default.
• W2083155989 cites W2044790794 @default.
• W2083155989 cites W2045223197 @default.
• W2083155989 cites W2045632404 @default.
• W2083155989 cites W2052407240 @default.
• W2083155989 cites W2061030154 @default.
• W2083155989 cites W2065618830 @default.
• W2083155989 cites W2070398408 @default.
• W2083155989 cites W2082619815 @default.
• W2083155989 cites W2083179636 @default.
• W2083155989 cites W2084292135 @default.
• W2083155989 cites W2088986234 @default.
• W2083155989 cites W2096251216 @default.
• W2083155989 cites W2099284750 @default.
• W2083155989 cites W2101018683 @default.
• W2083155989 cites W2105727933 @default.
• W2083155989 cites W2109119590 @default.
• W2083155989 cites W2113268356 @default.
• W2083155989 cites W2114111268 @default.
• W2083155989 cites W2122484262 @default.
• W2083155989 cites W2123404136 @default.
• W2083155989 cites W2124052130 @default.
• W2083155989 cites W2124299377 @default.
• W2083155989 cites W2125819930 @default.
• W2083155989 cites W2127455265 @default.
• W2083155989 cites W2128206941 @default.
• W2083155989 cites W2139826945 @default.
• W2083155989 cites W2152726111 @default.
• W2083155989 cites W2153473929 @default.
• W2083155989 cites W2156023431 @default.
• W2083155989 cites W2160270440 @default.
• W2083155989 cites W2160297973 @default.
• W2083155989 cites W2161444884 @default.
• W2083155989 cites W2163700401 @default.
• W2083155989 cites W2335925695 @default.
• W2083155989 cites W26912437 @default.
• W2083155989 cites W4255738759 @default.
• W2083155989 doi "https://doi.org/10.1371/journal.pone.0086326" @default.
• W2083155989 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3897671" @default.
• W2083155989 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24466027" @default.
• W2083155989 hasPublicationYear "2014" @default.
• W2083155989 type Work @default.
• W2083155989 sameAs 2083155989 @default.
• W2083155989 citedByCount "75" @default.
• W2083155989 countsByYear W20831559892014 @default.
• W2083155989 countsByYear W20831559892015 @default.
• W2083155989 countsByYear W20831559892016 @default.
• W2083155989 countsByYear W20831559892017 @default.
• W2083155989 countsByYear W20831559892018 @default.
• W2083155989 countsByYear W20831559892019 @default.
• W2083155989 countsByYear W20831559892020 @default.
• W2083155989 countsByYear W20831559892021 @default.
• W2083155989 countsByYear W20831559892022 @default.
• W2083155989 countsByYear W20831559892023 @default.
• W2083155989 crossrefType "journal-article" @default.
• W2083155989 hasAuthorship W2083155989A5013596240 @default.
• W2083155989 hasAuthorship W2083155989A5024648164 @default.
• W2083155989 hasAuthorship W2083155989A5033624164 @default.
• W2083155989 hasAuthorship W2083155989A5045492083 @default.
• W2083155989 hasAuthorship W2083155989A5050300826 @default.

• next