Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083164069> ?p ?o ?g. }
- W2083164069 endingPage "658" @default.
- W2083164069 startingPage "645" @default.
- W2083164069 abstract "We have demonstrated that kainate (KA) induces a reduction in mitochondrial Mn-superoxide dismutase (Mn-SOD) expression in the rat hippocampus and that KA-induced oxidative damage is more prominent in senile-prone (SAM-P8) than senile-resistant (SAM-R1) mice. To extend this, we examined whether KA seizure sensitivity contributed to mitochondrial degeneration in these mouse strains. KA-induced seizure susceptibility in SAM-P8 mice paralleled prominent increases in lipid peroxidation and protein oxidation and was accompanied by significant impairment in glutathione homeostasis in the hippocampus. These findings were more pronounced in the mitochondrial fraction than in the hippocampal homogenate. Consistently, KA-induced decreases in Mn-SOD protein expression, mitochondrial transmembrane potential, and uncoupling protein (UCP)-2 expression were more prominent in SAM-P8 than SAM-R1 mice. Marked release of cytochrome c from mitochondria into the cytosol and a higher level of caspase-3 cleavage were observed in KA-treated SAM-P8 mice. Additionally, electron microscopic evaluation indicated that KA-induced increases in mitochondrial damage and lipofuscin-like substances were more pronounced in SAM-P8 than SAM-R1 animals. These results suggest that KA-mediated mitochondrial oxidative stress contributed to hippocampal degeneration in the senile-prone mouse." @default.
- W2083164069 created "2016-06-24" @default.
- W2083164069 creator A5002587541 @default.
- W2083164069 creator A5004326077 @default.
- W2083164069 creator A5010710813 @default.
- W2083164069 creator A5037985631 @default.
- W2083164069 creator A5042683645 @default.
- W2083164069 creator A5043147431 @default.
- W2083164069 creator A5046260156 @default.
- W2083164069 creator A5065006809 @default.
- W2083164069 creator A5070673937 @default.
- W2083164069 creator A5078871120 @default.
- W2083164069 creator A5087619330 @default.
- W2083164069 creator A5089511507 @default.
- W2083164069 date "2008-04-01" @default.
- W2083164069 modified "2023-09-30" @default.
- W2083164069 title "Kainate-induced mitochondrial oxidative stress contributes to hippocampal degeneration in senescence-accelerated mice" @default.
- W2083164069 cites W1506520614 @default.
- W2083164069 cites W1538904872 @default.
- W2083164069 cites W1644953918 @default.
- W2083164069 cites W1699447737 @default.
- W2083164069 cites W1751574485 @default.
- W2083164069 cites W1964004644 @default.
- W2083164069 cites W1966429519 @default.
- W2083164069 cites W1966558330 @default.
- W2083164069 cites W1970749702 @default.
- W2083164069 cites W1973169178 @default.
- W2083164069 cites W1978875801 @default.
- W2083164069 cites W1981017578 @default.
- W2083164069 cites W1981611094 @default.
- W2083164069 cites W1982917530 @default.
- W2083164069 cites W1983221766 @default.
- W2083164069 cites W1983475501 @default.
- W2083164069 cites W1984900551 @default.
- W2083164069 cites W1985731963 @default.
- W2083164069 cites W1986119684 @default.
- W2083164069 cites W1988270870 @default.
- W2083164069 cites W1989730123 @default.
- W2083164069 cites W1995224512 @default.
- W2083164069 cites W1999378703 @default.
- W2083164069 cites W1999946108 @default.
- W2083164069 cites W2000813948 @default.
- W2083164069 cites W2000982876 @default.
- W2083164069 cites W2004079184 @default.
- W2083164069 cites W2010860052 @default.
- W2083164069 cites W2011123924 @default.
- W2083164069 cites W2016655414 @default.
- W2083164069 cites W2019836893 @default.
- W2083164069 cites W2020569812 @default.
- W2083164069 cites W2023105087 @default.
- W2083164069 cites W2024814132 @default.
- W2083164069 cites W2025681573 @default.
- W2083164069 cites W2027950911 @default.
- W2083164069 cites W2035062031 @default.
- W2083164069 cites W2035560284 @default.
- W2083164069 cites W2035862839 @default.
- W2083164069 cites W2037302221 @default.
- W2083164069 cites W2039813483 @default.
- W2083164069 cites W2042069967 @default.
- W2083164069 cites W2047777256 @default.
- W2083164069 cites W2049521887 @default.
- W2083164069 cites W2050297509 @default.
- W2083164069 cites W2051012868 @default.
- W2083164069 cites W2051950801 @default.
- W2083164069 cites W2054250154 @default.
- W2083164069 cites W2054706594 @default.
- W2083164069 cites W2055081487 @default.
- W2083164069 cites W2056620406 @default.
- W2083164069 cites W2058799973 @default.
- W2083164069 cites W2058987282 @default.
- W2083164069 cites W2062993402 @default.
- W2083164069 cites W2064182624 @default.
- W2083164069 cites W2067305246 @default.
- W2083164069 cites W2068568993 @default.
- W2083164069 cites W2068818348 @default.
- W2083164069 cites W2069347036 @default.
- W2083164069 cites W2070442887 @default.
- W2083164069 cites W2080125844 @default.
- W2083164069 cites W2081145901 @default.
- W2083164069 cites W2081645737 @default.
- W2083164069 cites W2082469108 @default.
- W2083164069 cites W2082722544 @default.
- W2083164069 cites W2083127760 @default.
- W2083164069 cites W2087598382 @default.
- W2083164069 cites W2088038548 @default.
- W2083164069 cites W2088076536 @default.
- W2083164069 cites W2088474892 @default.
- W2083164069 cites W2091258488 @default.
- W2083164069 cites W2091555690 @default.
- W2083164069 cites W2092384816 @default.
- W2083164069 cites W2092823267 @default.
- W2083164069 cites W2095816719 @default.
- W2083164069 cites W2098793103 @default.
- W2083164069 cites W2104822687 @default.
- W2083164069 cites W2113007696 @default.
- W2083164069 cites W2113999599 @default.
- W2083164069 cites W2121785931 @default.
- W2083164069 cites W2131643880 @default.