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- W2083168049 abstract "The endogenous gas, hydrogen sulfide (H2S), plays an important role in regulating cardiovascular function and inflammation. It also contributes to the pathogenesis of insulin resistance and glucose metabolism [1] , [2] , [3] . Recently, it has been reported that large amounts of H2S are formed from L-cysteine by cystathionine gamma lyase (CSE) in fat tissues and that H2S reduces glucose uptake in rat adipose tissue [3] . However, the biological roles of H2S in adipocytes and its contribution to adipogenesis are not yet clear. Here, we investigate whether H2S-synthesizing enzymes; cystathionine beta-synthase (CBS) and 3-mercaptopyruvate sulfurtransferase (3-MST), are endogenously expressed in adipocytes and play a role in adipogenesis. In the present experiments, we stimulated the mouse fibroblast-like cell line, 3T3L1, to differentiate into adipocytes for up to one week as a model of adipogenesis in vitro. Over 7 days differentiation, whole cell lysate at day 0, 1, 3, 5 and 7 were collected for Western blotting of CBS, CSE and 3-MST. Endogenous CBS and 3-MST in adipocytes peaked at day 5 of differentiation whereas CSE protein expression was up-regulated in a time-dependent manner and maximally expressed at day 7 (n = 3, P [4] , [5] , [6] , but that these enzymes are also present in large amounts in adipose tissue and that their up-regulation during adipogenesis promotes adipocyte maturation and prevent lipid degradation. Thus, it is possible that modulation of the H2S system may be useful for obesity treatment." @default.
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- W2083168049 date "2013-09-01" @default.
- W2083168049 modified "2023-09-27" @default.
- W2083168049 title "P40 The up-regulation role of H2S in 3T3L1 on adipogenesis" @default.
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- W2083168049 doi "https://doi.org/10.1016/j.niox.2013.06.102" @default.
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