FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083170353> ?p ?o ?g. }

• W2083170353 endingPage "963" @default.
• W2083170353 startingPage "958" @default.
• W2083170353 abstract "Hepatocyte growth factor/scatter factor (HGF/SF) and keratinocyte growth factor (KGF, also designated FGF-7) are paracrine growth factors secreted by mesenchymal cells and active on a variety of epithelial cell types. In this study, the biologic responses of keratinocytes to these paracrine growth factors were compared. Stimulation of mitogenesis, migration, plasminogen activator (PA) activity, and fibronectin production were examined using human foreskin keratinocytes cultured in serum-free MCDB 153 medium. Although the two factors stimulated a similar level of proliferation when cells were maintained for 5 d in 1.8 mM Ca++, the peak effect of KGF, observed at 10 ng/ml, was approximately threefold higher than that of HGF/SF when cells were in medium containing 0.15 mM Ca++. Both agents promoted the migration of cells in low-calcium medium (0.08 mM Ca++). However, the magnitude of the response was approximately twofold greater for HGF/SF at 10 ng/ml than KGF at the same concentration. None of the matrix proteins such as type I collagen, type IV collagen, laminin, or fibronectin either stimulated or suppressed HGF/SF- or KGF-stimulated keratinocyte migration. Both factors stimulated PA activity of the cell extracts, especially urokinase-type, with similar potencies. Promoted PA activity was maximal with the addition of 10 ng/ml of either factor. Neither factor increased the production of fibronectin under conditions in which transforming growth factor-beta 1 was active. These results indicate that HGF/SF and KGF, both recognized as paracrine growth factors, elicit distinctive patterns of response by keratinocytes, implying that they have different roles in epidermal physiology." @default.
• W2083170353 created "2016-06-24" @default.
• W2083170353 creator A5040549451 @default.
• W2083170353 creator A5041892610 @default.
• W2083170353 creator A5044380229 @default.
• W2083170353 creator A5053364502 @default.
• W2083170353 creator A5078324217 @default.
• W2083170353 date "1995-06-01" @default.
• W2083170353 modified "2023-10-03" @default.
• W2083170353 title "Comparative Study of Hepatocyte Growth Factor/Scatter Factor and Keratinocyte Growth Factor Effects on Human Keratinocytes" @default.
• W2083170353 cites W117902596 @default.
• W2083170353 cites W1549088009 @default.
• W2083170353 cites W1561043766 @default.
• W2083170353 cites W1576992587 @default.
• W2083170353 cites W1966398859 @default.
• W2083170353 cites W1984274933 @default.
• W2083170353 cites W1984294894 @default.
• W2083170353 cites W1985816441 @default.
• W2083170353 cites W1987824314 @default.
• W2083170353 cites W1995299530 @default.
• W2083170353 cites W2005487014 @default.
• W2083170353 cites W2005782838 @default.
• W2083170353 cites W2007904495 @default.
• W2083170353 cites W2010717111 @default.
• W2083170353 cites W2027150670 @default.
• W2083170353 cites W2027997722 @default.
• W2083170353 cites W2028804867 @default.
• W2083170353 cites W2035174231 @default.
• W2083170353 cites W2036381341 @default.
• W2083170353 cites W2042202567 @default.
• W2083170353 cites W2043671544 @default.
• W2083170353 cites W2054042846 @default.
• W2083170353 cites W2062763609 @default.
• W2083170353 cites W2072635469 @default.
• W2083170353 cites W2073292917 @default.
• W2083170353 cites W2074641624 @default.
• W2083170353 cites W2080068749 @default.
• W2083170353 cites W2090323246 @default.
• W2083170353 cites W2093309677 @default.
• W2083170353 cites W2106059813 @default.
• W2083170353 cites W2106406104 @default.
• W2083170353 cites W2111002265 @default.
• W2083170353 cites W2113045327 @default.
• W2083170353 cites W2113065332 @default.
• W2083170353 cites W2113142255 @default.
• W2083170353 cites W2129849944 @default.
• W2083170353 cites W2134311390 @default.
• W2083170353 cites W2147150467 @default.
• W2083170353 cites W2158433109 @default.
• W2083170353 cites W2201682365 @default.
• W2083170353 doi "https://doi.org/10.1111/1523-1747.ep12606221" @default.
• W2083170353 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7769266" @default.
• W2083170353 hasPublicationYear "1995" @default.
• W2083170353 type Work @default.
• W2083170353 sameAs 2083170353 @default.
• W2083170353 citedByCount "77" @default.
• W2083170353 countsByYear W20831703532012 @default.
• W2083170353 countsByYear W20831703532013 @default.
• W2083170353 countsByYear W20831703532014 @default.
• W2083170353 countsByYear W20831703532015 @default.
• W2083170353 countsByYear W20831703532016 @default.
• W2083170353 countsByYear W20831703532017 @default.
• W2083170353 countsByYear W20831703532018 @default.
• W2083170353 countsByYear W20831703532020 @default.
• W2083170353 countsByYear W20831703532021 @default.
• W2083170353 crossrefType "journal-article" @default.
• W2083170353 hasAuthorship W2083170353A5040549451 @default.
• W2083170353 hasAuthorship W2083170353A5041892610 @default.
• W2083170353 hasAuthorship W2083170353A5044380229 @default.
• W2083170353 hasAuthorship W2083170353A5053364502 @default.
• W2083170353 hasAuthorship W2083170353A5078324217 @default.
• W2083170353 hasBestOaLocation W20831703531 @default.
• W2083170353 hasConcept C126322002 @default.
• W2083170353 hasConcept C134018914 @default.
• W2083170353 hasConcept C170493617 @default.
• W2083170353 hasConcept C185592680 @default.
• W2083170353 hasConcept C189165786 @default.
• W2083170353 hasConcept C2775960820 @default.
• W2083170353 hasConcept C2776996007 @default.
• W2083170353 hasConcept C2777074287 @default.
• W2083170353 hasConcept C2778615670 @default.
• W2083170353 hasConcept C2779679481 @default.
• W2083170353 hasConcept C54355233 @default.
• W2083170353 hasConcept C55493867 @default.
• W2083170353 hasConcept C71924100 @default.
• W2083170353 hasConcept C7876069 @default.
• W2083170353 hasConcept C81885089 @default.
• W2083170353 hasConcept C86492073 @default.
• W2083170353 hasConcept C86803240 @default.
• W2083170353 hasConcept C95444343 @default.
• W2083170353 hasConceptScore W2083170353C126322002 @default.
• W2083170353 hasConceptScore W2083170353C134018914 @default.
• W2083170353 hasConceptScore W2083170353C170493617 @default.
• W2083170353 hasConceptScore W2083170353C185592680 @default.
• W2083170353 hasConceptScore W2083170353C189165786 @default.
• W2083170353 hasConceptScore W2083170353C2775960820 @default.
• W2083170353 hasConceptScore W2083170353C2776996007 @default.
• W2083170353 hasConceptScore W2083170353C2777074287 @default.

• next