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• W2083173639 endingPage "647" @default.
• W2083173639 startingPage "627" @default.
• W2083173639 abstract "The G-quadruplex (G4) elements comprise a class of nucleic acid structures formed by stacking of guanine base quartets in a quadruple helix. This G4 DNA can form within or across single-stranded DNA molecules and is mutually exclusive with duplex B-form DNA. The reversibility and structural diversity of G4s make them highly versatile genetic structures, as demonstrated by their roles in various functions including telomere metabolism, genome maintenance, immunoglobulin gene diversification, transcription, and translation. Sequence motifs capable of forming G4 DNA are typically located in telomere repeat DNA and other non-telomeric genomic loci. To investigate their potential roles in a large-genome model plant species, we computationally identified 149,988 non-telomeric G4 motifs in maize (Zea mays L., B73 AGPv2), 29% of which were in non-repetitive genomic regions. G4 motif hotspots exhibited non-random enrichment in genes at two locations on the antisense strand, one in the 5′ UTR and the other at the 5′ end of the first intron. Several genic G4 motifs were shown to adopt sequence-specific and potassium-dependent G4 DNA structures in vitro. The G4 motifs were prevalent in key regulatory genes associated with hypoxia (group VII ERFs), oxidative stress (DJ-1/GATase1), and energy status (AMPK/SnRK) pathways. They also showed statistical enrichment for genes in metabolic pathways that function in glycolysis, sugar degradation, inositol metabolism, and base excision repair. Collectively, the maize G4 motifs may represent conditional regulatory elements that can aid in energy status gene responses. Such a network of elements could provide a mechanistic basis for linking energy status signals to gene regulation in maize, a model genetic system and major world crop species for feed, food, and fuel." @default.
• W2083173639 created "2016-06-24" @default.
• W2083173639 creator A5023468002 @default.
• W2083173639 creator A5045214155 @default.
• W2083173639 creator A5048365760 @default.
• W2083173639 creator A5051635531 @default.
• W2083173639 creator A5074103258 @default.
• W2083173639 creator A5075575222 @default.
• W2083173639 creator A5086191068 @default.
• W2083173639 date "2014-12-01" @default.
• W2083173639 modified "2023-10-14" @default.
• W2083173639 title "G-Quadruplex (G4) Motifs in the Maize (Zea mays L.) Genome Are Enriched at Specific Locations in Thousands of Genes Coupled to Energy Status, Hypoxia, Low Sugar, and Nutrient Deprivation" @default.
• W2083173639 cites W1490914592 @default.
• W2083173639 cites W1611113373 @default.
• W2083173639 cites W1721320694 @default.
• W2083173639 cites W1772575001 @default.
• W2083173639 cites W1929664900 @default.
• W2083173639 cites W1946965338 @default.
• W2083173639 cites W1964978797 @default.
• W2083173639 cites W1966708146 @default.
• W2083173639 cites W1966739834 @default.
• W2083173639 cites W1967196129 @default.
• W2083173639 cites W1970604878 @default.
• W2083173639 cites W1974175020 @default.
• W2083173639 cites W1975690779 @default.
• W2083173639 cites W1977855826 @default.
• W2083173639 cites W1979715837 @default.
• W2083173639 cites W1981775109 @default.
• W2083173639 cites W1983428994 @default.
• W2083173639 cites W1985471440 @default.
• W2083173639 cites W1986662234 @default.
• W2083173639 cites W1990635146 @default.
• W2083173639 cites W1992219360 @default.
• W2083173639 cites W1992932809 @default.
• W2083173639 cites W1995005227 @default.
• W2083173639 cites W1999276461 @default.
• W2083173639 cites W2000123655 @default.
• W2083173639 cites W2000136433 @default.
• W2083173639 cites W2000929500 @default.
• W2083173639 cites W2002675613 @default.
• W2083173639 cites W2005868568 @default.
• W2083173639 cites W2006518267 @default.
• W2083173639 cites W2007634776 @default.
• W2083173639 cites W2009287131 @default.
• W2083173639 cites W2010670785 @default.
• W2083173639 cites W2012214305 @default.
• W2083173639 cites W2013265123 @default.
• W2083173639 cites W2014704298 @default.
• W2083173639 cites W2015625843 @default.
• W2083173639 cites W2016491299 @default.
• W2083173639 cites W2019058450 @default.
• W2083173639 cites W2020118719 @default.
• W2083173639 cites W2020652742 @default.
• W2083173639 cites W2020957341 @default.
• W2083173639 cites W2021191052 @default.
• W2083173639 cites W2022287291 @default.
• W2083173639 cites W2025252613 @default.
• W2083173639 cites W2025334731 @default.
• W2083173639 cites W2026760241 @default.
• W2083173639 cites W2027047459 @default.
• W2083173639 cites W2027696068 @default.
• W2083173639 cites W2031977411 @default.
• W2083173639 cites W2036712724 @default.
• W2083173639 cites W2037626481 @default.
• W2083173639 cites W2040031153 @default.
• W2083173639 cites W2044484965 @default.
• W2083173639 cites W2044723896 @default.
• W2083173639 cites W2045284889 @default.
• W2083173639 cites W2045840287 @default.
• W2083173639 cites W2046043517 @default.
• W2083173639 cites W2047038417 @default.
• W2083173639 cites W2047339071 @default.
• W2083173639 cites W2047950070 @default.
• W2083173639 cites W2051642566 @default.
• W2083173639 cites W2052024409 @default.
• W2083173639 cites W2052968074 @default.
• W2083173639 cites W2056201880 @default.
• W2083173639 cites W2058901737 @default.
• W2083173639 cites W2060077088 @default.
• W2083173639 cites W2062451058 @default.
• W2083173639 cites W2068847894 @default.
• W2083173639 cites W2073722866 @default.
• W2083173639 cites W2075470292 @default.
• W2083173639 cites W2078491086 @default.
• W2083173639 cites W2080661557 @default.
• W2083173639 cites W2083703501 @default.
• W2083173639 cites W2090411726 @default.
• W2083173639 cites W2091254099 @default.
• W2083173639 cites W2091876286 @default.
• W2083173639 cites W2092424765 @default.
• W2083173639 cites W2097521277 @default.
• W2083173639 cites W2106226450 @default.
• W2083173639 cites W2106231921 @default.
• W2083173639 cites W2106697551 @default.
• W2083173639 cites W2106736633 @default.
• W2083173639 cites W2108649941 @default.
• W2083173639 cites W2111157010 @default.
• W2083173639 cites W2111278461 @default.

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