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• W2083173658 abstract "Renal injury resulting from renal ablation induced by 5/6 nephrectomy (5/6NX) is associated with oxidant stress, glomerular hypertension, hyperfiltration, and impaired Nrf2-Keap1 pathway. The purpose of this work was to know if the bifunctional antioxidant curcumin may induce nuclear translocation of Nrf2 and prevents 5/6NX-induced oxidant stress, renal injury, decrease in antioxidant enzymes, and glomerular hypertension and hyperfiltration. Four groups of rats were studied: (1) control, (2) 5/6NX, (3) 5/6NX<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mrow><mml:mo>+</mml:mo><mml:mtext>CUR,</mml:mtext></mml:mrow></mml:math>and (4) CUR (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mrow><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>8</mml:mn></mml:mrow></mml:math>–10). Curcumin was given by gavage to NX5/6<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mrow><mml:mo>+</mml:mo><mml:mtext>CUR</mml:mtext></mml:mrow></mml:math>and CUR groups (60 mg/kg/day) starting seven days before surgery. Rats were studied 30 days after NX5/6 or sham surgery. Curcumin attenuated 5/6NX-induced proteinuria, systemic and glomerular hypertension, hyperfiltration, glomerular sclerosis, interstitial fibrosis, interstitial inflammation, and increase in plasma creatinine and blood urea nitrogen. This protective effect was associated with enhanced nuclear translocation of Nrf2 and with prevention of 5/6NX-induced oxidant stress and decrease in the activity of antioxidant enzymes. It is concluded that the protective effect of curcumin against 5/6NX-induced glomerular and systemic hypertension, hyperfiltration, renal dysfunction, and renal injury was associated with the nuclear translocation of Nrf2 and the prevention of both oxidant stress and the decrease of antioxidant enzymes." @default.
• W2083173658 created "2016-06-24" @default.
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• W2083173658 date "2012-01-01" @default.
• W2083173658 modified "2023-10-17" @default.
• W2083173658 title "Curcumin Induces Nrf2 Nuclear Translocation and Prevents Glomerular Hypertension, Hyperfiltration, Oxidant Stress, and the Decrease in Antioxidant Enzymes in 5/6 Nephrectomized Rats" @default.
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• W2083173658 doi "https://doi.org/10.1155/2012/269039" @default.
• W2083173658 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3424005" @default.
• W2083173658 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22919438" @default.
• W2083173658 hasPublicationYear "2012" @default.
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