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- W2083173755 abstract "OBJECTIVE: Hypogonadotropic hypogonadism (HH) is a rare but well- known cause of male infertility. The diagnosis is established when low serum gonadotropin level coincide with low serum testosterone (T) and when azospermia or oligospermia is detected on semen analysis. Our aim is to evaluate the outcome of men with HH undergoing intracytoplasmic sperm injection (ICSI). DESIGN: Retrospective review. MATERIALS AND METHODS: Data from 31 HH patients undergoing ICSI cycles in the period from January 2004 to January 2009 was analyzed. Hormone replacement therapy was given before ICSI. Human chorionic gonadotropin (hCG) 5000 once weekly was begun. After 6 months of hCG therapy, when serum T Ievels were in the normal range, human menopausal gonadotropin (hMG) 75 IU 3 times weekly was added.Surgically retrieved spermatozoa (% 34.5) or ejaculated sperm (% 65.5) was used for ICSI. Testicular tissue was collected by microdissection testicular sperm extraction (micro TESE) and processed for ICSI. Of the 31 cycles, 2 of them were cancelled because no sperm was found in micro-TESE. Once spermatozoa were found, MII stage oocytes were fertilized by ICSI. Motility enhancers were employed where the spermatozoa so recovered were immotile. The fertilization pattern was recorded 16-18 hrs after ICSI and ultimately, clinical pregnancy was confirmed by the presence of a gestational sac in ultrasonography. RESULTS: The mean age of the patients was 34.82 years. Their average serum FSH and T levels were 0.90 IU/L and 147ng/ml respectively. The mean number of oocytes retrieved was 12.03. The fertilization rate was 83% (231/278).Clinical pregnancy rate and live birth rate per embryo transfer were 51.7% (15/29) and 41.3% (12/29) respectively. These included 10 singletons and 2 twins, totaling 14 healthy children. CONCLUSION: ICSI is a very effective technique in treating male infertility associated with HH. Couples presenting with infertility with a male partner diagnosed with HH have acceptible fertilization and pregnancy rates with ICSI." @default.
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- W2083173755 date "2010-09-01" @default.
- W2083173755 modified "2023-09-28" @default.
- W2083173755 title "Evaluation of intracytoplasmic sperm injection outcomes in men with hypogonadotropic hypogonadism: 5 years' experience" @default.
- W2083173755 doi "https://doi.org/10.1016/j.fertnstert.2010.07.061" @default.
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