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W2083174986 abstract "The development of novel H5N1 influenza vaccines to elicit a broad immune response is a priority in veterinary and human public health. In this report, a baculovirus vector was used to construct bivalent recombinant baculovirus vaccine encoding H5N1 influenza virus hemagglutinin proteins (BV-HAs) from clade 2.3.4 and clade 9 influenza viruses. Mice immunized with 5×10(7) IFU BV-HAs developed significantly high levels of H5-specific neutralizing antibodies and cellular immunity that conferred 100% protection against infection with H5N1 influenza viruses. This study suggests that baculovirus-delivered multi-hemagglutinin proteins might serve as a candidate vaccine for the prevention of pre-pandemic and pandemic H5N1 influenza viruses." @default.
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W2083174986 date "2011-12-01" @default.
W2083174986 modified "2023-09-25" @default.
W2083174986 title "Protective immunity elicited by a pseudotyped baculovirus-mediated bivalent H5N1 influenza vaccine" @default.
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W2083174986 doi "https://doi.org/10.1016/j.antiviral.2011.10.001" @default.
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