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• W2083175059 abstract "Morphine loses its ability to fight pain after chronic use. Now, Howard Gutstein and his colleagues report that morphine induces release of PDGF, and blockade of PDGFR signaling can reestablish morphine analgesic efficacy in rats that have become tolerant. For centuries, opioid drugs have been the mainstay of chronic pain treatment. However, over time analgesic tolerance develops, leaving few treatment options. Here we show that platelet-derived growth factor receptor-β (PDGFR-β)-mediated signaling plays a key role in morphine tolerance. PDGFR-β inhibition selectively eliminates morphine tolerance in rats. PDGFR-β inhibitors are widely used and well tolerated, suggesting that clinical translation of our findings could reduce the suffering endured by individuals with intractable pain." @default.
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• W2083175059 date "2012-02-19" @default.
• W2083175059 modified "2023-10-14" @default.
• W2083175059 title "Blockade of PDGFR-β activation eliminates morphine analgesic tolerance" @default.
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• W2083175059 doi "https://doi.org/10.1038/nm.2633" @default.
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