Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083177549> ?p ?o ?g. }
- W2083177549 endingPage "1633" @default.
- W2083177549 startingPage "1621" @default.
- W2083177549 abstract "Abstract γδ T cells localize at mammalian epithelial surfaces to exert both protective and regulatory roles in response to infections. We have previously characterized the Mexican axolotl ( Ambystoma mexicanum ) T cell receptor delta (TRD) chain. In this study, TRD repertoires in spleen, liver, intestine and skin from larvae, pre‐adult and adult axolotls were examined and compared to the thymic TRD repertoire. A TRDV transcript without N/D diversity, TRDV1S1‐TRDJ1, dominates the TRD repertoires until sexual maturation. In adult tissues, this canonical transcript is replaced by another dominant TRDV1S1‐TRDJ1 transcript. In the thymus, these two transcripts are detected early in development. Our results suggest that γδ T cells that express the canonical TRDV1S1‐TRDJ1 transcript emerge from the thymus and colonize the peripheral tissues, where they are selectively expanded by recurrent ligands. This particular situation is probably related to the neotenic state and the slow development of the axolotl. In thymectomized axolotls, TRD repertoires appear different from those of normal axolotls, suggesting that extrathymic γδ T cell differentiation could occur. Gene expression analysis showed the importance of the gut in T cell development." @default.
- W2083177549 created "2016-06-24" @default.
- W2083177549 creator A5000992837 @default.
- W2083177549 creator A5012387017 @default.
- W2083177549 creator A5033644518 @default.
- W2083177549 creator A5037745331 @default.
- W2083177549 creator A5073577653 @default.
- W2083177549 creator A5080646436 @default.
- W2083177549 date "2007-05-24" @default.
- W2083177549 modified "2023-10-17" @default.
- W2083177549 title "Highly restricted diversity of TCR delta chains of the amphibian Mexican axolotl (Ambystomamexicanum) in peripheral tissues" @default.
- W2083177549 cites W1492322782 @default.
- W2083177549 cites W1493159751 @default.
- W2083177549 cites W1502909173 @default.
- W2083177549 cites W1572362644 @default.
- W2083177549 cites W1605391507 @default.
- W2083177549 cites W1615090701 @default.
- W2083177549 cites W1625191949 @default.
- W2083177549 cites W1920167267 @default.
- W2083177549 cites W1957564469 @default.
- W2083177549 cites W1968697332 @default.
- W2083177549 cites W1972120590 @default.
- W2083177549 cites W1980229488 @default.
- W2083177549 cites W1986583635 @default.
- W2083177549 cites W1996642422 @default.
- W2083177549 cites W1999874812 @default.
- W2083177549 cites W2003797329 @default.
- W2083177549 cites W2003935644 @default.
- W2083177549 cites W2013889679 @default.
- W2083177549 cites W2014012740 @default.
- W2083177549 cites W2016373176 @default.
- W2083177549 cites W2019985217 @default.
- W2083177549 cites W2020100658 @default.
- W2083177549 cites W202718674 @default.
- W2083177549 cites W2028159810 @default.
- W2083177549 cites W2032979843 @default.
- W2083177549 cites W2034391780 @default.
- W2083177549 cites W2034963222 @default.
- W2083177549 cites W2035657505 @default.
- W2083177549 cites W2039347430 @default.
- W2083177549 cites W2043462667 @default.
- W2083177549 cites W2044143193 @default.
- W2083177549 cites W2044874211 @default.
- W2083177549 cites W2051020992 @default.
- W2083177549 cites W2055016844 @default.
- W2083177549 cites W2061699947 @default.
- W2083177549 cites W2063700930 @default.
- W2083177549 cites W2081676952 @default.
- W2083177549 cites W2083001645 @default.
- W2083177549 cites W2085196479 @default.
- W2083177549 cites W2091829184 @default.
- W2083177549 cites W2097815590 @default.
- W2083177549 cites W2114951959 @default.
- W2083177549 cites W2124877326 @default.
- W2083177549 cites W2126043518 @default.
- W2083177549 cites W2130470396 @default.
- W2083177549 cites W2138270253 @default.
- W2083177549 cites W2141661308 @default.
- W2083177549 cites W2148695112 @default.
- W2083177549 cites W4213085061 @default.
- W2083177549 cites W4229892776 @default.
- W2083177549 cites W4239414528 @default.
- W2083177549 cites W4239684092 @default.
- W2083177549 cites W4313422298 @default.
- W2083177549 doi "https://doi.org/10.1002/eji.200636375" @default.
- W2083177549 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17523213" @default.
- W2083177549 hasPublicationYear "2007" @default.
- W2083177549 type Work @default.
- W2083177549 sameAs 2083177549 @default.
- W2083177549 citedByCount "11" @default.
- W2083177549 countsByYear W20831775492014 @default.
- W2083177549 countsByYear W20831775492016 @default.
- W2083177549 countsByYear W20831775492018 @default.
- W2083177549 countsByYear W20831775492020 @default.
- W2083177549 countsByYear W20831775492021 @default.
- W2083177549 countsByYear W20831775492023 @default.
- W2083177549 crossrefType "journal-article" @default.
- W2083177549 hasAuthorship W2083177549A5000992837 @default.
- W2083177549 hasAuthorship W2083177549A5012387017 @default.
- W2083177549 hasAuthorship W2083177549A5033644518 @default.
- W2083177549 hasAuthorship W2083177549A5037745331 @default.
- W2083177549 hasAuthorship W2083177549A5073577653 @default.
- W2083177549 hasAuthorship W2083177549A5080646436 @default.
- W2083177549 hasBestOaLocation W20831775491 @default.
- W2083177549 hasConcept C106374777 @default.
- W2083177549 hasConcept C153911025 @default.
- W2083177549 hasConcept C170493617 @default.
- W2083177549 hasConcept C171056886 @default.
- W2083177549 hasConcept C18903297 @default.
- W2083177549 hasConcept C19317047 @default.
- W2083177549 hasConcept C203014093 @default.
- W2083177549 hasConcept C2776090121 @default.
- W2083177549 hasConcept C2779945282 @default.
- W2083177549 hasConcept C2781465898 @default.
- W2083177549 hasConcept C2908669727 @default.
- W2083177549 hasConcept C54355233 @default.
- W2083177549 hasConcept C86803240 @default.
- W2083177549 hasConcept C8891405 @default.