FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083202264> ?p ?o ?g. }

• W2083202264 endingPage "1134" @default.
• W2083202264 startingPage "1126" @default.
• W2083202264 abstract "We evaluated the association between polymorphisms of cytochrome P450 2A6 (CYP2A6)/excision repair cross-complementation group 1 (ERCC1)/X-ray repair cross-complementing group 1(XRCC1) and treatment outcomes of metastatic gastric cancer (MGC) patients treated with S-1/cisplatin. Among MGC patients (n=108), who received S-1 (40 mg m−2 b.i.d., days 1–14) and cisplatin (60 mg m−2, day 1) every 3 weeks, we analysed the wild-type allele (W) and variants (V) of CYP2A6 (*4, *7, *9, *10), and the polymorphisms of ERCC1 (rs11615, rs3212986) and XRCC1 (rs25487). Patients having fewer CYP2A6 variants had better response rates (W/W vs W/V other than *1/*4 vs V/V or *1/*4=66.7 vs 58.3 vs 32.3%; P=0.008), time to progression (TTP) (7.2 vs 6.1 vs 3.5 months, P=0.021), and overall survival (23.2 vs 15.4 vs 12.0 months, P=0.004). ERCC1 19442C>A (rs3212986) was also associated with response rate (C/C, 46.7% vs C/A, 55.3% vs A/A, 87.5%) (P=0.048) and TTP (4.4 vs 7.6 vs 7.9 months) (P=0.012). Patients carrying both risk genotypes of CYP2A6 (V/V or 1/*4) and ERCC1 19442C>A (C/C) vs those carrying none showed an adjusted odds ratio of 0.113 (P=0.004) for response, and adjusted hazard ratios of 3.748 (P=0.0001) for TTP and 2.961 (P=0.006) for death. Polymorphisms of CYP2A6 and ERCC1 19442C>A correlated with the efficacy of S-1/cisplatin." @default.
• W2083202264 created "2016-06-24" @default.
• W2083202264 creator A5008401080 @default.
• W2083202264 creator A5021490853 @default.
• W2083202264 creator A5031447770 @default.
• W2083202264 creator A5032088387 @default.
• W2083202264 creator A5035891370 @default.
• W2083202264 creator A5039623591 @default.
• W2083202264 creator A5039731164 @default.
• W2083202264 creator A5045738935 @default.
• W2083202264 creator A5052122266 @default.
• W2083202264 creator A5066449485 @default.
• W2083202264 creator A5076808925 @default.
• W2083202264 creator A5079140720 @default.
• W2083202264 creator A5085106564 @default.
• W2083202264 date "2011-03-01" @default.
• W2083202264 modified "2023-10-18" @default.
• W2083202264 title "CYP2A6 and ERCC1 polymorphisms correlate with efficacy of S-1 plus cisplatin in metastatic gastric cancer patients" @default.
• W2083202264 cites W1968703649 @default.
• W2083202264 cites W1977022507 @default.
• W2083202264 cites W1977575240 @default.
• W2083202264 cites W1979694104 @default.
• W2083202264 cites W1987502189 @default.
• W2083202264 cites W2004256112 @default.
• W2083202264 cites W2004718750 @default.
• W2083202264 cites W2014260980 @default.
• W2083202264 cites W2014982128 @default.
• W2083202264 cites W2015658785 @default.
• W2083202264 cites W2018522063 @default.
• W2083202264 cites W2020830322 @default.
• W2083202264 cites W2048099302 @default.
• W2083202264 cites W2048391139 @default.
• W2083202264 cites W2049765467 @default.
• W2083202264 cites W2060323836 @default.
• W2083202264 cites W2077902459 @default.
• W2083202264 cites W2080020175 @default.
• W2083202264 cites W2083207377 @default.
• W2083202264 cites W2104477572 @default.
• W2083202264 cites W2111578366 @default.
• W2083202264 cites W2113329270 @default.
• W2083202264 cites W2121908040 @default.
• W2083202264 cites W2123322249 @default.
• W2083202264 cites W2127773543 @default.
• W2083202264 cites W2128328462 @default.
• W2083202264 cites W2129271383 @default.
• W2083202264 cites W2131972171 @default.
• W2083202264 cites W2137991416 @default.
• W2083202264 cites W2139248078 @default.
• W2083202264 cites W2139819296 @default.
• W2083202264 cites W2144154516 @default.
• W2083202264 cites W2148725710 @default.
• W2083202264 cites W2157978805 @default.
• W2083202264 cites W2164411042 @default.
• W2083202264 cites W2168655513 @default.
• W2083202264 cites W2171075804 @default.
• W2083202264 cites W2227164869 @default.
• W2083202264 doi "https://doi.org/10.1038/bjc.2011.24" @default.
• W2083202264 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3068488" @default.
• W2083202264 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21364592" @default.
• W2083202264 hasPublicationYear "2011" @default.
• W2083202264 type Work @default.
• W2083202264 sameAs 2083202264 @default.
• W2083202264 citedByCount "50" @default.
• W2083202264 countsByYear W20832022642012 @default.
• W2083202264 countsByYear W20832022642013 @default.
• W2083202264 countsByYear W20832022642014 @default.
• W2083202264 countsByYear W20832022642015 @default.
• W2083202264 countsByYear W20832022642016 @default.
• W2083202264 countsByYear W20832022642017 @default.
• W2083202264 countsByYear W20832022642018 @default.
• W2083202264 countsByYear W20832022642019 @default.
• W2083202264 countsByYear W20832022642020 @default.
• W2083202264 countsByYear W20832022642021 @default.
• W2083202264 countsByYear W20832022642022 @default.
• W2083202264 countsByYear W20832022642023 @default.
• W2083202264 crossrefType "journal-article" @default.
• W2083202264 hasAuthorship W2083202264A5008401080 @default.
• W2083202264 hasAuthorship W2083202264A5021490853 @default.
• W2083202264 hasAuthorship W2083202264A5031447770 @default.
• W2083202264 hasAuthorship W2083202264A5032088387 @default.
• W2083202264 hasAuthorship W2083202264A5035891370 @default.
• W2083202264 hasAuthorship W2083202264A5039623591 @default.
• W2083202264 hasAuthorship W2083202264A5039731164 @default.
• W2083202264 hasAuthorship W2083202264A5045738935 @default.
• W2083202264 hasAuthorship W2083202264A5052122266 @default.
• W2083202264 hasAuthorship W2083202264A5066449485 @default.
• W2083202264 hasAuthorship W2083202264A5076808925 @default.
• W2083202264 hasAuthorship W2083202264A5079140720 @default.
• W2083202264 hasAuthorship W2083202264A5085106564 @default.
• W2083202264 hasBestOaLocation W20832022641 @default.
• W2083202264 hasConcept C104317684 @default.
• W2083202264 hasConcept C104451858 @default.
• W2083202264 hasConcept C121608353 @default.
• W2083202264 hasConcept C126322002 @default.
• W2083202264 hasConcept C134935766 @default.
• W2083202264 hasConcept C135763542 @default.
• W2083202264 hasConcept C143998085 @default.
• W2083202264 hasConcept C153209595 @default.

• next