FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083206138> ?p ?o ?g. }

• W2083206138 endingPage "e114410" @default.
• W2083206138 startingPage "e114410" @default.
• W2083206138 abstract "The increasing clinical importance of infections caused by multidrug resistant Acinetobacter baumannii warrants the development of novel approaches for prevention and treatment. In this context, vaccination of certain patient populations may contribute to reducing the morbidity and mortality caused by this pathogen. Vaccines against Gram-negative bacteria based on inactivated bacterial cells are highly immunogenic and have been shown to produce protective immunity against a number of bacterial species. However, the high endotoxin levels present in these vaccines due to the presence of lipopolysaccharide complicates their use in human vaccination. In the present study, we used a laboratory-derived strain of A. baumannii that completely lacks lipopolysaccharide due to a mutation in the lpxD gene (IB010), one of the genes involved in the first steps of lipopolysaccharide biosynthesis, for vaccination. We demonstrate that IB010 has greatly reduced endotoxin content (<1.0 endotoxin unit/106 cells) compared to wild type cells. Immunization with formalin inactivated IB010 produced a robust antibody response consisting of both IgG1 and IgG2c subtypes. Mice immunized with IB010 had significantly lower post-infection tissue bacterial loads and significantly lower serum levels of the pro-inflammatory cytokines IL-1β, TNF-α and IL-6 compared to control mice in a mouse model of disseminated A. baumannii infection. Importantly, immunized mice were protected from infection with the ATCC 19606 strain and an A. baumannii clinical isolate. These data suggest that immunization with inactivated A. baumannii whole cells deficient in lipopolysaccharide could serve as the basis for a vaccine for the prevention of infection caused by A. baumannii." @default.
• W2083206138 created "2016-06-24" @default.
• W2083206138 creator A5035389792 @default.
• W2083206138 creator A5076347067 @default.
• W2083206138 creator A5078163920 @default.
• W2083206138 creator A5087945181 @default.
• W2083206138 date "2014-12-08" @default.
• W2083206138 modified "2023-10-02" @default.
• W2083206138 title "Immunization with Lipopolysaccharide-Deficient Whole Cells Provides Protective Immunity in an Experimental Mouse Model of Acinetobacter baumannii Infection" @default.
• W2083206138 cites W145819544 @default.
• W2083206138 cites W1976894397 @default.
• W2083206138 cites W1982895831 @default.
• W2083206138 cites W1991633654 @default.
• W2083206138 cites W1998133815 @default.
• W2083206138 cites W2025413826 @default.
• W2083206138 cites W2028487827 @default.
• W2083206138 cites W2036456340 @default.
• W2083206138 cites W2038176331 @default.
• W2083206138 cites W2055846623 @default.
• W2083206138 cites W2056807133 @default.
• W2083206138 cites W2057929627 @default.
• W2083206138 cites W2063730198 @default.
• W2083206138 cites W2083657436 @default.
• W2083206138 cites W2101515145 @default.
• W2083206138 cites W2103023022 @default.
• W2083206138 cites W2104549414 @default.
• W2083206138 cites W2104906857 @default.
• W2083206138 cites W2105838577 @default.
• W2083206138 cites W2106715126 @default.
• W2083206138 cites W2112310123 @default.
• W2083206138 cites W2114165631 @default.
• W2083206138 cites W2117689688 @default.
• W2083206138 cites W2119858925 @default.
• W2083206138 cites W2138382635 @default.
• W2083206138 cites W2140750141 @default.
• W2083206138 cites W2142140480 @default.
• W2083206138 cites W2152683133 @default.
• W2083206138 cites W2163433389 @default.
• W2083206138 cites W2163829208 @default.
• W2083206138 cites W2173272774 @default.
• W2083206138 cites W4250421841 @default.
• W2083206138 doi "https://doi.org/10.1371/journal.pone.0114410" @default.
• W2083206138 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4259314" @default.
• W2083206138 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25485716" @default.
• W2083206138 hasPublicationYear "2014" @default.
• W2083206138 type Work @default.
• W2083206138 sameAs 2083206138 @default.
• W2083206138 citedByCount "45" @default.
• W2083206138 countsByYear W20832061382015 @default.
• W2083206138 countsByYear W20832061382016 @default.
• W2083206138 countsByYear W20832061382017 @default.
• W2083206138 countsByYear W20832061382018 @default.
• W2083206138 countsByYear W20832061382019 @default.
• W2083206138 countsByYear W20832061382020 @default.
• W2083206138 countsByYear W20832061382021 @default.
• W2083206138 countsByYear W20832061382022 @default.
• W2083206138 countsByYear W20832061382023 @default.
• W2083206138 crossrefType "journal-article" @default.
• W2083206138 hasAuthorship W2083206138A5035389792 @default.
• W2083206138 hasAuthorship W2083206138A5076347067 @default.
• W2083206138 hasAuthorship W2083206138A5078163920 @default.
• W2083206138 hasAuthorship W2083206138A5087945181 @default.
• W2083206138 hasBestOaLocation W20832061381 @default.
• W2083206138 hasConcept C151730666 @default.
• W2083206138 hasConcept C159047783 @default.
• W2083206138 hasConcept C159654299 @default.
• W2083206138 hasConcept C203014093 @default.
• W2083206138 hasConcept C22070199 @default.
• W2083206138 hasConcept C2776315533 @default.
• W2083206138 hasConcept C2777637488 @default.
• W2083206138 hasConcept C2778754761 @default.
• W2083206138 hasConcept C2779341262 @default.
• W2083206138 hasConcept C2779343474 @default.
• W2083206138 hasConcept C2780801004 @default.
• W2083206138 hasConcept C523546767 @default.
• W2083206138 hasConcept C54355233 @default.
• W2083206138 hasConcept C86803240 @default.
• W2083206138 hasConcept C8891405 @default.
• W2083206138 hasConcept C89423630 @default.
• W2083206138 hasConceptScore W2083206138C151730666 @default.
• W2083206138 hasConceptScore W2083206138C159047783 @default.
• W2083206138 hasConceptScore W2083206138C159654299 @default.
• W2083206138 hasConceptScore W2083206138C203014093 @default.
• W2083206138 hasConceptScore W2083206138C22070199 @default.
• W2083206138 hasConceptScore W2083206138C2776315533 @default.
• W2083206138 hasConceptScore W2083206138C2777637488 @default.
• W2083206138 hasConceptScore W2083206138C2778754761 @default.
• W2083206138 hasConceptScore W2083206138C2779341262 @default.
• W2083206138 hasConceptScore W2083206138C2779343474 @default.
• W2083206138 hasConceptScore W2083206138C2780801004 @default.
• W2083206138 hasConceptScore W2083206138C523546767 @default.
• W2083206138 hasConceptScore W2083206138C54355233 @default.
• W2083206138 hasConceptScore W2083206138C86803240 @default.
• W2083206138 hasConceptScore W2083206138C8891405 @default.
• W2083206138 hasConceptScore W2083206138C89423630 @default.
• W2083206138 hasIssue "12" @default.
• W2083206138 hasLocation W20832061381 @default.
• W2083206138 hasLocation W20832061382 @default.

• next