Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083219790> ?p ?o ?g. }
- W2083219790 endingPage "4180" @default.
- W2083219790 startingPage "4156" @default.
- W2083219790 abstract "The amyloid hypothesis asserts that excess production or reduced clearance of the amyloid-β (Aβ) peptides in the brain initiates a sequence of events that ultimately lead to Alzheimer’s disease and dementia. The Aβ hypothesis has identified BACE1 as a therapeutic target to treat Alzheimer’s and led to medicinal chemistry efforts to design its inhibitors both in the pharmaceutical industry and in academia. This review summarizes two distinct categories of inhibitors designed based on conformational states of “closed” and “open” forms of the enzyme. In each category the inhibitors are classified based on the core catalytic interaction group or the aspartyl binding motif (ABM). This review covers the description of inhibitors in each ABM class with X-ray crystal structures of key compounds, their binding modes, related structure–activity data highlighting potency advances, and additional properties such as selectivity profile, P-gp efflux, pharmacokinetic, and pharmacodynamic data." @default.
- W2083219790 created "2016-06-24" @default.
- W2083219790 creator A5043219268 @default.
- W2083219790 creator A5046362807 @default.
- W2083219790 creator A5047234096 @default.
- W2083219790 creator A5062610210 @default.
- W2083219790 creator A5069974203 @default.
- W2083219790 creator A5070745882 @default.
- W2083219790 date "2013-04-05" @default.
- W2083219790 modified "2023-10-17" @default.
- W2083219790 title "Structure-Based Design of β-Site APP Cleaving Enzyme 1 (BACE1) Inhibitors for the Treatment of Alzheimer’s Disease" @default.
- W2083219790 cites W1489055816 @default.
- W2083219790 cites W1510383592 @default.
- W2083219790 cites W1574375664 @default.
- W2083219790 cites W1587266299 @default.
- W2083219790 cites W1644122431 @default.
- W2083219790 cites W1854324009 @default.
- W2083219790 cites W1859408168 @default.
- W2083219790 cites W1945268331 @default.
- W2083219790 cites W1967164727 @default.
- W2083219790 cites W1968152951 @default.
- W2083219790 cites W1968405603 @default.
- W2083219790 cites W1974388266 @default.
- W2083219790 cites W1976295381 @default.
- W2083219790 cites W1978017004 @default.
- W2083219790 cites W1978815746 @default.
- W2083219790 cites W1978818669 @default.
- W2083219790 cites W1982204196 @default.
- W2083219790 cites W1986160001 @default.
- W2083219790 cites W1988137843 @default.
- W2083219790 cites W1990129121 @default.
- W2083219790 cites W1990387719 @default.
- W2083219790 cites W1990755847 @default.
- W2083219790 cites W1991767197 @default.
- W2083219790 cites W1992443809 @default.
- W2083219790 cites W1992625275 @default.
- W2083219790 cites W1993859868 @default.
- W2083219790 cites W1995311106 @default.
- W2083219790 cites W1995930302 @default.
- W2083219790 cites W1997068236 @default.
- W2083219790 cites W2000531954 @default.
- W2083219790 cites W2001210466 @default.
- W2083219790 cites W2002633391 @default.
- W2083219790 cites W2003932771 @default.
- W2083219790 cites W2005447377 @default.
- W2083219790 cites W2007421279 @default.
- W2083219790 cites W2008547919 @default.
- W2083219790 cites W2009979602 @default.
- W2083219790 cites W2011480702 @default.
- W2083219790 cites W2011505858 @default.
- W2083219790 cites W2012875369 @default.
- W2083219790 cites W2015587575 @default.
- W2083219790 cites W2017538343 @default.
- W2083219790 cites W2018725720 @default.
- W2083219790 cites W2020265146 @default.
- W2083219790 cites W2021372963 @default.
- W2083219790 cites W2022113679 @default.
- W2083219790 cites W2022507083 @default.
- W2083219790 cites W2022649344 @default.
- W2083219790 cites W2022851923 @default.
- W2083219790 cites W2022973223 @default.
- W2083219790 cites W2026031997 @default.
- W2083219790 cites W2026053103 @default.
- W2083219790 cites W2026398446 @default.
- W2083219790 cites W2026503476 @default.
- W2083219790 cites W2027853783 @default.
- W2083219790 cites W2028785960 @default.
- W2083219790 cites W2031231593 @default.
- W2083219790 cites W2032462716 @default.
- W2083219790 cites W2033673783 @default.
- W2083219790 cites W2035905220 @default.
- W2083219790 cites W2036028081 @default.
- W2083219790 cites W2038896140 @default.
- W2083219790 cites W2040333979 @default.
- W2083219790 cites W2042197305 @default.
- W2083219790 cites W2044735125 @default.
- W2083219790 cites W2045391529 @default.
- W2083219790 cites W2046652481 @default.
- W2083219790 cites W2047568911 @default.
- W2083219790 cites W2051087207 @default.
- W2083219790 cites W2052931631 @default.
- W2083219790 cites W2054140553 @default.
- W2083219790 cites W2056257486 @default.
- W2083219790 cites W2057090966 @default.
- W2083219790 cites W2058614488 @default.
- W2083219790 cites W2059030964 @default.
- W2083219790 cites W2059552870 @default.
- W2083219790 cites W2061479978 @default.
- W2083219790 cites W2062283435 @default.
- W2083219790 cites W2062458432 @default.
- W2083219790 cites W2062491057 @default.
- W2083219790 cites W2066907464 @default.
- W2083219790 cites W2067211644 @default.
- W2083219790 cites W2070713982 @default.
- W2083219790 cites W2074883671 @default.
- W2083219790 cites W2076664119 @default.
- W2083219790 cites W2078129146 @default.
- W2083219790 cites W2081453188 @default.