FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083224653> ?p ?o ?g. }

• W2083224653 endingPage "2806" @default.
• W2083224653 startingPage "2796" @default.
• W2083224653 abstract "When biological macromolecules are used as therapeutic agents, it is often necessary to introduce non-natural chemical modifications to improve their pharmaceutical properties. The final products are complex structures where entities such as proteins, peptides, oligonucleotides, and small molecule drugs may be covalently linked to each other, or may include chemically modified biological moieties. An accurate in silico representation of these complex structures is essential, as it forms the basis for their electronic registration, storage, analysis, and visualization. The size of these molecules (henceforth referred to as biomolecules) often makes them too unwieldy and impractical to represent at the atomic level, while the presence of non-natural chemical modifications makes it impossible to represent them by sequence alone. Here we describe the Hierarchical Editing Language for Macromolecules (HELM) and demonstrate its utility in the representation of structures such as antisense oligonucleotides, short interference RNAs, peptides, proteins, and antibody drug conjugates." @default.
• W2083224653 created "2016-06-24" @default.
• W2083224653 creator A5012276279 @default.
• W2083224653 creator A5041588764 @default.
• W2083224653 creator A5047169849 @default.
• W2083224653 creator A5063839992 @default.
• W2083224653 creator A5086382447 @default.
• W2083224653 date "2012-09-26" @default.
• W2083224653 modified "2023-10-01" @default.
• W2083224653 title "HELM: A Hierarchical Notation Language for Complex Biomolecule Structure Representation" @default.
• W2083224653 cites W1975147762 @default.
• W2083224653 cites W1983817726 @default.
• W2083224653 cites W1994137238 @default.
• W2083224653 cites W1998997530 @default.
• W2083224653 cites W1999638776 @default.
• W2083224653 cites W2037109408 @default.
• W2083224653 cites W2038702914 @default.
• W2083224653 cites W2049654081 @default.
• W2083224653 cites W2051810242 @default.
• W2083224653 cites W2096975829 @default.
• W2083224653 cites W2951811035 @default.
• W2083224653 cites W4247689850 @default.
• W2083224653 doi "https://doi.org/10.1021/ci3001925" @default.
• W2083224653 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22947017" @default.
• W2083224653 hasPublicationYear "2012" @default.
• W2083224653 type Work @default.
• W2083224653 sameAs 2083224653 @default.
• W2083224653 citedByCount "46" @default.
• W2083224653 countsByYear W20832246532013 @default.
• W2083224653 countsByYear W20832246532014 @default.
• W2083224653 countsByYear W20832246532015 @default.
• W2083224653 countsByYear W20832246532017 @default.
• W2083224653 countsByYear W20832246532018 @default.
• W2083224653 countsByYear W20832246532019 @default.
• W2083224653 countsByYear W20832246532020 @default.
• W2083224653 countsByYear W20832246532021 @default.
• W2083224653 countsByYear W20832246532022 @default.
• W2083224653 countsByYear W20832246532023 @default.
• W2083224653 crossrefType "journal-article" @default.
• W2083224653 hasAuthorship W2083224653A5012276279 @default.
• W2083224653 hasAuthorship W2083224653A5041588764 @default.
• W2083224653 hasAuthorship W2083224653A5047169849 @default.
• W2083224653 hasAuthorship W2083224653A5063839992 @default.
• W2083224653 hasAuthorship W2083224653A5086382447 @default.
• W2083224653 hasBestOaLocation W20832246531 @default.
• W2083224653 hasConcept C104317684 @default.
• W2083224653 hasConcept C129312508 @default.
• W2083224653 hasConcept C171852809 @default.
• W2083224653 hasConcept C17744445 @default.
• W2083224653 hasConcept C185592680 @default.
• W2083224653 hasConcept C199539241 @default.
• W2083224653 hasConcept C204389451 @default.
• W2083224653 hasConcept C21951064 @default.
• W2083224653 hasConcept C2775905019 @default.
• W2083224653 hasConcept C2776359362 @default.
• W2083224653 hasConcept C2778112365 @default.
• W2083224653 hasConcept C33923547 @default.
• W2083224653 hasConcept C41008148 @default.
• W2083224653 hasConcept C45357846 @default.
• W2083224653 hasConcept C49853544 @default.
• W2083224653 hasConcept C552990157 @default.
• W2083224653 hasConcept C55493867 @default.
• W2083224653 hasConcept C70721500 @default.
• W2083224653 hasConcept C86803240 @default.
• W2083224653 hasConcept C94375191 @default.
• W2083224653 hasConcept C94625758 @default.
• W2083224653 hasConceptScore W2083224653C104317684 @default.
• W2083224653 hasConceptScore W2083224653C129312508 @default.
• W2083224653 hasConceptScore W2083224653C171852809 @default.
• W2083224653 hasConceptScore W2083224653C17744445 @default.
• W2083224653 hasConceptScore W2083224653C185592680 @default.
• W2083224653 hasConceptScore W2083224653C199539241 @default.
• W2083224653 hasConceptScore W2083224653C204389451 @default.
• W2083224653 hasConceptScore W2083224653C21951064 @default.
• W2083224653 hasConceptScore W2083224653C2775905019 @default.
• W2083224653 hasConceptScore W2083224653C2776359362 @default.
• W2083224653 hasConceptScore W2083224653C2778112365 @default.
• W2083224653 hasConceptScore W2083224653C33923547 @default.
• W2083224653 hasConceptScore W2083224653C41008148 @default.
• W2083224653 hasConceptScore W2083224653C45357846 @default.
• W2083224653 hasConceptScore W2083224653C49853544 @default.
• W2083224653 hasConceptScore W2083224653C552990157 @default.
• W2083224653 hasConceptScore W2083224653C55493867 @default.
• W2083224653 hasConceptScore W2083224653C70721500 @default.
• W2083224653 hasConceptScore W2083224653C86803240 @default.
• W2083224653 hasConceptScore W2083224653C94375191 @default.
• W2083224653 hasConceptScore W2083224653C94625758 @default.
• W2083224653 hasIssue "10" @default.
• W2083224653 hasLocation W20832246531 @default.
• W2083224653 hasLocation W20832246532 @default.
• W2083224653 hasOpenAccess W2083224653 @default.
• W2083224653 hasPrimaryLocation W20832246531 @default.
• W2083224653 hasRelatedWork W1487585044 @default.
• W2083224653 hasRelatedWork W2048954882 @default.
• W2083224653 hasRelatedWork W2140008189 @default.
• W2083224653 hasRelatedWork W2169401431 @default.
• W2083224653 hasRelatedWork W2799858598 @default.
• W2083224653 hasRelatedWork W3093005337 @default.

• next