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• W2083236593 abstract "Cytoplasmic double-stranded DNA triggers cell death and secretion of the pro-inflammatory cytokine IL-1beta in macrophages. Recent reports now describe the mechanism underlying this observation. Upon sensing of DNA, the HIN-200 family member AIM2 triggers the assembly of the inflammasome, culminating in caspase-1 activation, IL-1beta maturation and pyroptotic cell death." @default.
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• W2083236593 date "2009-03-01" @default.
• W2083236593 modified "2023-10-13" @default.
• W2083236593 title "Innate Immunity: Cytoplasmic DNA Sensing by the AIM2 Inflammasome" @default.
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• W2083236593 doi "https://doi.org/10.1016/j.cub.2009.02.011" @default.
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