FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083258052> ?p ?o ?g. }

• W2083258052 endingPage "95" @default.
• W2083258052 startingPage "89" @default.
• W2083258052 abstract "Objective. To characterize the anthropometric and pharmacotherapeutic variables related to acute emesis over repeat courses of cisplatin-containing regimens (≥50 mg/m survival analysis. 2 ) by means of survival analysis. Methods. A prospective, cross-sectional non-controlled study was started to analyse acute vomiting in patients treated in a general hospital. The patients received an intravenous combination of drugs based on metoclopramide (two 3 mg/kg doses), diphenhydramine (20 mg) and dexamethasone (20 mg) as first choice antiemetic treatment. An intravenous regimen based on ondansetron (8 mg) and dexamethasone (20 mg) was given as an alternative regimen. Therapeutic failure was defined as the recording of one or more vomiting episodes on a self-evaluation sheet. Other variables included were chemotherapeutic regimen, antiemetic regimen, gender, age, weight and height. The statistical analysis was developed using the Cox proportional hazards model. Results. Eighty-eight patients were finally included in the study, 16 women (18%) and 72 men (82%). The metoclopramide-based regimen was administered to 74 patients (84%) and the ondansetron-based regimen to 14 patients (15%). The univariate analysis showed that any variable included in the study was significant. The multivariate survival analysis retained three variables: height (hazard ratio 1.22), gender (hazard ratio 2.12) and weight (hazard ratio 1.44) of the patients. It is hypothesized that gender and anthropometrics of patients could represent differences in pharmacokinetic and/or pharmacodynamic behaviour of cisplatin and/or antiemetics. The potential role of these parameters in these drugs is discussed. Conclusions. Emesis over repeat courses in cisplatin-containing regimens seems a function of the gender and anthropometrics of patients, irrespective of the antiemetic regimen and the emetogenicity of the cytostatics. Dosing individualization of cisplatin and/or antiemetics based on pharmacokinetic and/or pharmacodynamic parameters can be a valid tool to increase the effectiveness and safety of these drugs." @default.
• W2083258052 created "2016-06-24" @default.
• W2083258052 creator A5013029292 @default.
• W2083258052 creator A5017438716 @default.
• W2083258052 creator A5073990004 @default.
• W2083258052 creator A5078307013 @default.
• W2083258052 date "2002-06-01" @default.
• W2083258052 modified "2023-10-16" @default.
• W2083258052 title "Gender and anthropometrics of patients undergoing cisplatin-containing chemotherapy as determinants of acute emesis over repeat courses" @default.
• W2083258052 cites W1832113570 @default.
• W2083258052 cites W1892571469 @default.
• W2083258052 cites W1968859817 @default.
• W2083258052 cites W1972643741 @default.
• W2083258052 cites W1988118458 @default.
• W2083258052 cites W1996967709 @default.
• W2083258052 cites W2012005071 @default.
• W2083258052 cites W2012469966 @default.
• W2083258052 cites W2016996792 @default.
• W2083258052 cites W2054485301 @default.
• W2083258052 cites W2077643759 @default.
• W2083258052 cites W2085116801 @default.
• W2083258052 cites W2095281605 @default.
• W2083258052 cites W2098851757 @default.
• W2083258052 cites W2132038546 @default.
• W2083258052 cites W2142585989 @default.
• W2083258052 cites W2328562816 @default.
• W2083258052 cites W2735203303 @default.
• W2083258052 cites W4239036808 @default.
• W2083258052 cites W2164270312 @default.
• W2083258052 doi "https://doi.org/10.1191/1078155202jp094oa" @default.
• W2083258052 hasPublicationYear "2002" @default.
• W2083258052 type Work @default.
• W2083258052 sameAs 2083258052 @default.
• W2083258052 citedByCount "0" @default.
• W2083258052 crossrefType "journal-article" @default.
• W2083258052 hasAuthorship W2083258052A5013029292 @default.
• W2083258052 hasAuthorship W2083258052A5017438716 @default.
• W2083258052 hasAuthorship W2083258052A5073990004 @default.
• W2083258052 hasAuthorship W2083258052A5078307013 @default.
• W2083258052 hasConcept C126322002 @default.
• W2083258052 hasConcept C207103383 @default.
• W2083258052 hasConcept C2777170512 @default.
• W2083258052 hasConcept C2778479196 @default.
• W2083258052 hasConcept C2780401358 @default.
• W2083258052 hasConcept C2780580376 @default.
• W2083258052 hasConcept C2780852908 @default.
• W2083258052 hasConcept C2780884295 @default.
• W2083258052 hasConcept C2781413609 @default.
• W2083258052 hasConcept C42219234 @default.
• W2083258052 hasConcept C44249647 @default.
• W2083258052 hasConcept C71924100 @default.
• W2083258052 hasConceptScore W2083258052C126322002 @default.
• W2083258052 hasConceptScore W2083258052C207103383 @default.
• W2083258052 hasConceptScore W2083258052C2777170512 @default.
• W2083258052 hasConceptScore W2083258052C2778479196 @default.
• W2083258052 hasConceptScore W2083258052C2780401358 @default.
• W2083258052 hasConceptScore W2083258052C2780580376 @default.
• W2083258052 hasConceptScore W2083258052C2780852908 @default.
• W2083258052 hasConceptScore W2083258052C2780884295 @default.
• W2083258052 hasConceptScore W2083258052C2781413609 @default.
• W2083258052 hasConceptScore W2083258052C42219234 @default.
• W2083258052 hasConceptScore W2083258052C44249647 @default.
• W2083258052 hasConceptScore W2083258052C71924100 @default.
• W2083258052 hasIssue "2-3" @default.
• W2083258052 hasLocation W20832580521 @default.
• W2083258052 hasOpenAccess W2083258052 @default.
• W2083258052 hasPrimaryLocation W20832580521 @default.
• W2083258052 hasRelatedWork W1580722585 @default.
• W2083258052 hasRelatedWork W161558341 @default.
• W2083258052 hasRelatedWork W1824703102 @default.
• W2083258052 hasRelatedWork W2008904273 @default.
• W2083258052 hasRelatedWork W2147223907 @default.
• W2083258052 hasRelatedWork W2375131032 @default.
• W2083258052 hasRelatedWork W2388169959 @default.
• W2083258052 hasRelatedWork W4238760384 @default.
• W2083258052 hasRelatedWork W4253142519 @default.
• W2083258052 hasRelatedWork W2737193785 @default.
• W2083258052 hasVolume "8" @default.
• W2083258052 isParatext "false" @default.
• W2083258052 isRetracted "false" @default.
• W2083258052 magId "2083258052" @default.
• W2083258052 workType "article" @default.