FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083271250> ?p ?o ?g. }

• W2083271250 abstract "In vitro dermal absorption tests were conducted with the (14)C-ring-labelled herbicide 2,4-dichlorophenoxyacetic acid (2,4-D), dissolved in acetone and applied to dermatomed skin (0.5 mm) of a number of species at dose rates of 7-8 mug/cm(2). Skin absorption was determined for 48 hr after exposure using an in vitro flow-through system. Skin absorption was calculated from the sum of the percentage recovery of (14)C activity in the receiver solution and the percentage recovery in the methanol washes of the skin at 48 hr and the skin digest samples. Two receiver solutions, Ringer's saline, and Hanks' HEPES buffered saline with 4% serum albumin were used. Listed in decreasing order, the total percentage in vitro dermal absorptions obtained by 48 hr after exposure for the five skin types were: 47 +/- 4.3% [tissue cultured Testskin; Hanks' receiver (HR)], 40 +/- 4.5% (rat; HR), 19 +/- 1.8% (human; HR), 14 +/- 2.3% (hairless guinea pig; HR), 14 +/- 8.8% (pig; Ringer's receiver). The percentage recovery of the radiolabel in soapy water skin washes at 24 hr, methanol washes and skin digests at 48 hr, and of (14)C-labelled volatiles collected in air traps at 48 hr after exposure are reported. Comparative in vivo studies were conducted for 14 days after exposure and demonstrated 32 +/- 3.9 and 28 +/- 7.8% recovery of (14)C in the urine of rats (dose rate, 3 mug/cm(2)) and guinea pigs (dose rate, 4 mug/cm(2)), respectively. Total faecal recovery was 2 +/- 0.3 and 9 +/- 3.5% for rats and guinea pigs, respectively. Analysis of tissue taken at autopsy 14 day after dosing demonstrated a total tissue recovery of (14)C activity of 1 +/- 0.1 and 2 +/- 0.5% in rats and guinea pigs, respectively. Including the (14)C activity extracted from the skin removed from the dose site at 14 days after exposure, the total recovery of dermally absorbed residues was 49 +/- 10.4 and 40 +/- 9.9% in rats and guinea pigs, respectively. Recovery of (14)C activity from soapy water skin washes conducted at 24 hr after exposure was 28 +/- 8.1 and 43 +/- 9.0% for rats and guinea pigs, respectively. Recovery in skin patches was 18% (guinea pigs) and 26% (rats). In summary, the in vitro/in vivo concordance for the rat dermal absorption data was good but the in vitro data for hairless guinea pigs underestimated the in vivo absorption, and therefore for 2,4-D, rat skin may provide a better model of percutaneous absorption." @default.
• W2083271250 created "2016-06-24" @default.
• W2083271250 creator A5023326649 @default.
• W2083271250 creator A5057098458 @default.
• W2083271250 creator A5064346230 @default.
• W2083271250 date "1994-12-01" @default.
• W2083271250 modified "2023-10-05" @default.
• W2083271250 title "In vitro dermal absorption of pesticides: V. In vivo and in vitro comparison of the herbicide 2,4-dichlorophenoxyacetic acid in rat, guinea pig, pig, human and tissue-cultured skin" @default.
• W2083271250 cites W1977243870 @default.
• W2083271250 cites W1992228155 @default.
• W2083271250 cites W1999357170 @default.
• W2083271250 cites W2008510976 @default.
• W2083271250 cites W2035835606 @default.
• W2083271250 cites W2038804735 @default.
• W2083271250 cites W2044061234 @default.
• W2083271250 cites W2061272124 @default.
• W2083271250 cites W2065704047 @default.
• W2083271250 cites W2084916477 @default.
• W2083271250 cites W2475855346 @default.
• W2083271250 cites W2913514575 @default.
• W2083271250 cites W66156708 @default.
• W2083271250 doi "https://doi.org/10.1016/0887-2333(94)90112-0" @default.
• W2083271250 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20693091" @default.
• W2083271250 hasPublicationYear "1994" @default.
• W2083271250 type Work @default.
• W2083271250 sameAs 2083271250 @default.
• W2083271250 citedByCount "12" @default.
• W2083271250 countsByYear W20832712502012 @default.
• W2083271250 countsByYear W20832712502014 @default.
• W2083271250 countsByYear W20832712502015 @default.
• W2083271250 countsByYear W20832712502019 @default.
• W2083271250 crossrefType "journal-article" @default.
• W2083271250 hasAuthorship W2083271250A5023326649 @default.
• W2083271250 hasAuthorship W2083271250A5057098458 @default.
• W2083271250 hasAuthorship W2083271250A5064346230 @default.
• W2083271250 hasConcept C121332964 @default.
• W2083271250 hasConcept C125287762 @default.
• W2083271250 hasConcept C134018914 @default.
• W2083271250 hasConcept C150903083 @default.
• W2083271250 hasConcept C161176658 @default.
• W2083271250 hasConcept C185592680 @default.
• W2083271250 hasConcept C202751555 @default.
• W2083271250 hasConcept C207001950 @default.
• W2083271250 hasConcept C24890656 @default.
• W2083271250 hasConcept C2777397205 @default.
• W2083271250 hasConcept C2777459323 @default.
• W2083271250 hasConcept C2778664912 @default.
• W2083271250 hasConcept C2778815084 @default.
• W2083271250 hasConcept C2781213060 @default.
• W2083271250 hasConcept C43617362 @default.
• W2083271250 hasConcept C54355233 @default.
• W2083271250 hasConcept C55493867 @default.
• W2083271250 hasConcept C59822182 @default.
• W2083271250 hasConcept C6557445 @default.
• W2083271250 hasConcept C86803240 @default.
• W2083271250 hasConcept C98274493 @default.
• W2083271250 hasConceptScore W2083271250C121332964 @default.
• W2083271250 hasConceptScore W2083271250C125287762 @default.
• W2083271250 hasConceptScore W2083271250C134018914 @default.
• W2083271250 hasConceptScore W2083271250C150903083 @default.
• W2083271250 hasConceptScore W2083271250C161176658 @default.
• W2083271250 hasConceptScore W2083271250C185592680 @default.
• W2083271250 hasConceptScore W2083271250C202751555 @default.
• W2083271250 hasConceptScore W2083271250C207001950 @default.
• W2083271250 hasConceptScore W2083271250C24890656 @default.
• W2083271250 hasConceptScore W2083271250C2777397205 @default.
• W2083271250 hasConceptScore W2083271250C2777459323 @default.
• W2083271250 hasConceptScore W2083271250C2778664912 @default.
• W2083271250 hasConceptScore W2083271250C2778815084 @default.
• W2083271250 hasConceptScore W2083271250C2781213060 @default.
• W2083271250 hasConceptScore W2083271250C43617362 @default.
• W2083271250 hasConceptScore W2083271250C54355233 @default.
• W2083271250 hasConceptScore W2083271250C55493867 @default.
• W2083271250 hasConceptScore W2083271250C59822182 @default.
• W2083271250 hasConceptScore W2083271250C6557445 @default.
• W2083271250 hasConceptScore W2083271250C86803240 @default.
• W2083271250 hasConceptScore W2083271250C98274493 @default.
• W2083271250 hasLocation W20832712501 @default.
• W2083271250 hasLocation W20832712502 @default.
• W2083271250 hasOpenAccess W2083271250 @default.
• W2083271250 hasPrimaryLocation W20832712501 @default.
• W2083271250 hasRelatedWork W1488009717 @default.
• W2083271250 hasRelatedWork W1966686390 @default.
• W2083271250 hasRelatedWork W1983530931 @default.
• W2083271250 hasRelatedWork W1984268920 @default.
• W2083271250 hasRelatedWork W2007023362 @default.
• W2083271250 hasRelatedWork W2061829983 @default.
• W2083271250 hasRelatedWork W2064231441 @default.
• W2083271250 hasRelatedWork W2441595591 @default.
• W2083271250 hasRelatedWork W2462290832 @default.
• W2083271250 hasRelatedWork W4229625553 @default.
• W2083271250 isParatext "false" @default.
• W2083271250 isRetracted "false" @default.
• W2083271250 magId "2083271250" @default.
• W2083271250 workType "article" @default.