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- W2083273017 abstract "THE OBESITY HYPOVENTILATION SYNDROME, consisting of extreme obesity, somnolence, plethora, and edema,' is uncommon but life-threatening in children? -'~ Vital capacity is decreased, the cardiac silhouette is enlarged, and hypoxemia and hypercapnea are present, especially during sleep. Weight reduction may help correct ventilation/. '-' but weight reduction is difficult to achieve, nearly impossible to maintain, and alone may not completely correct the ventilatory abnormality. 1 ~ ~ Progesterone, whether endogenous (as in pregnancy and the luteal phase of the menstrual cycle -*~) or exogenous (in healthy male and female volunteers 1~ ~), increases minute ventilation and reduces alveolar Pco2, probably by increasing the sensitivity of the respiratory center to carbon dioxide?' Intramuscularly 7 and sublingually 1:' administered progesterone correct alveolar hypoventilation in adults with OHS. The use of orally administered progesterone in this condition or progesterone treatment by any route of administration in children with OHS has not been reported. We document here the correction of alveolar hypoventilation by parenteral, and subsequently oral, administration of progesterone in a child with OHS complicating the Prader-Willi syndrome.'" @default.
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- W2083273017 date "1977-03-01" @default.
- W2083273017 modified "2023-09-25" @default.
- W2083273017 title "Progesterone treatment of the obesity hypoventilation syndrome in a child" @default.
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- W2083273017 doi "https://doi.org/10.1016/s0022-3476(77)80720-8" @default.
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