FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083278876> ?p ?o ?g. }

• W2083278876 endingPage "310" @default.
• W2083278876 startingPage "302" @default.
• W2083278876 abstract "SUMMARY Aim: This study investigated the role of NAD(P)H oxidase in transforming growth factor‐β1 (TGF‐β1)‐induced reactive oxygen species (ROS) generation, monocyte chemoattractant protein‐1 (MCP‐1), and interleukin‐6 (IL‐6) expression in rat renal tubular epithelial NRK‐52E cells. Methods: The cells were treated with 10 ng/mL TGF‐β1, either in the presence or absence of the NAD(P)H oxidase inhibitor, diphenyleneiodonium (DPI), or short hairpin RNA (shRNA) suppressing p67phox expression. Expression of NAD(P)H oxidase subunits, MCP‐1, and IL‐6 at the mRNA levels was detected by reverse transcription polymerase chain reaction, while expression of NAD(P)H oxidase subunit p67phox protein was analyzed by western blot and MCP‐1 by enzyme‐linked immunosorbent assay. The cellular ROS generation was visualized using 2′,7′‐dichlorodihydrofluorescein diacetate by confocal microscopy. Results: Compared to control, TGF‐β1 upregulated NAD(P)H oxidase subunit p67phox mRNA by 3.59‐fold ( P < 0.01), but had no effect on p22phox, gp91phox and p47phox NAD(P)H subunits. TGF‐β1 was also able to significantly increase intracellular ROS ( P < 0.05), MCP‐1 ( P < 0.01) and IL‐6 ( P < 0.05) expression in NRK‐52E cells. Further studies showed that generation of ROS and upregulation of MCP‐1 and IL‐6 by TGF‐β1 were significantly blocked by addition of DPI or shRNA‐p67phox ( P < 0.01), suggesting that these effects were NAD(P)H oxidase‐dependent. Conclusion: TGF‐β1 differentially regulates the expression of NAD(P)H oxidase subunits and mediates MCP‐1 and IL‐6 expression in rat renal tubular cells via the NAD(P)H oxidase/p67phox‐dependent mechanism." @default.
• W2083278876 created "2016-06-24" @default.
• W2083278876 creator A5005011787 @default.
• W2083278876 creator A5034181458 @default.
• W2083278876 creator A5044364430 @default.
• W2083278876 creator A5051258511 @default.
• W2083278876 creator A5061472855 @default.
• W2083278876 creator A5079260779 @default.
• W2083278876 creator A5085440313 @default.
• W2083278876 creator A5089079624 @default.
• W2083278876 date "2009-04-01" @default.
• W2083278876 modified "2023-10-15" @default.
• W2083278876 title "Role of NAD(P)H oxidase in transforming growth factor-β1-induced monocyte chemoattractant protein-1 and interleukin-6 expression in rat renal tubular epithelial cells" @default.
• W2083278876 cites W1897680432 @default.
• W2083278876 cites W1909526655 @default.
• W2083278876 cites W1977378846 @default.
• W2083278876 cites W1995130186 @default.
• W2083278876 cites W2026358430 @default.
• W2083278876 cites W2027693573 @default.
• W2083278876 cites W2041575203 @default.
• W2083278876 cites W2044149640 @default.
• W2083278876 cites W2048569323 @default.
• W2083278876 cites W2050780076 @default.
• W2083278876 cites W2066950983 @default.
• W2083278876 cites W2068166346 @default.
• W2083278876 cites W2083569066 @default.
• W2083278876 cites W2089808802 @default.
• W2083278876 cites W2101466169 @default.
• W2083278876 cites W2104251051 @default.
• W2083278876 cites W2109662937 @default.
• W2083278876 cites W2111478784 @default.
• W2083278876 cites W2122308499 @default.
• W2083278876 cites W2122389047 @default.
• W2083278876 cites W2123774062 @default.
• W2083278876 cites W2137515520 @default.
• W2083278876 cites W2143016221 @default.
• W2083278876 cites W2161561361 @default.
• W2083278876 cites W2163106864 @default.
• W2083278876 cites W2166662752 @default.
• W2083278876 cites W2278461574 @default.
• W2083278876 cites W2317051808 @default.
• W2083278876 doi "https://doi.org/10.1111/j.1440-1797.2008.01072.x" @default.
• W2083278876 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19207862" @default.
• W2083278876 hasPublicationYear "2009" @default.
• W2083278876 type Work @default.
• W2083278876 sameAs 2083278876 @default.
• W2083278876 citedByCount "20" @default.
• W2083278876 countsByYear W20832788762012 @default.
• W2083278876 countsByYear W20832788762013 @default.
• W2083278876 countsByYear W20832788762015 @default.
• W2083278876 countsByYear W20832788762016 @default.
• W2083278876 countsByYear W20832788762018 @default.
• W2083278876 countsByYear W20832788762020 @default.
• W2083278876 countsByYear W20832788762023 @default.
• W2083278876 crossrefType "journal-article" @default.
• W2083278876 hasAuthorship W2083278876A5005011787 @default.
• W2083278876 hasAuthorship W2083278876A5034181458 @default.
• W2083278876 hasAuthorship W2083278876A5044364430 @default.
• W2083278876 hasAuthorship W2083278876A5051258511 @default.
• W2083278876 hasAuthorship W2083278876A5061472855 @default.
• W2083278876 hasAuthorship W2083278876A5079260779 @default.
• W2083278876 hasAuthorship W2083278876A5085440313 @default.
• W2083278876 hasAuthorship W2083278876A5089079624 @default.
• W2083278876 hasConcept C104317684 @default.
• W2083278876 hasConcept C153911025 @default.
• W2083278876 hasConcept C173396325 @default.
• W2083278876 hasConcept C181199279 @default.
• W2083278876 hasConcept C185592680 @default.
• W2083278876 hasConcept C190232843 @default.
• W2083278876 hasConcept C190283241 @default.
• W2083278876 hasConcept C203014093 @default.
• W2083278876 hasConcept C2776415932 @default.
• W2083278876 hasConcept C2779719074 @default.
• W2083278876 hasConcept C2781184567 @default.
• W2083278876 hasConcept C2781252958 @default.
• W2083278876 hasConcept C2781308076 @default.
• W2083278876 hasConcept C38485361 @default.
• W2083278876 hasConcept C48349386 @default.
• W2083278876 hasConcept C55493867 @default.
• W2083278876 hasConcept C75520062 @default.
• W2083278876 hasConcept C86803240 @default.
• W2083278876 hasConceptScore W2083278876C104317684 @default.
• W2083278876 hasConceptScore W2083278876C153911025 @default.
• W2083278876 hasConceptScore W2083278876C173396325 @default.
• W2083278876 hasConceptScore W2083278876C181199279 @default.
• W2083278876 hasConceptScore W2083278876C185592680 @default.
• W2083278876 hasConceptScore W2083278876C190232843 @default.
• W2083278876 hasConceptScore W2083278876C190283241 @default.
• W2083278876 hasConceptScore W2083278876C203014093 @default.
• W2083278876 hasConceptScore W2083278876C2776415932 @default.
• W2083278876 hasConceptScore W2083278876C2779719074 @default.
• W2083278876 hasConceptScore W2083278876C2781184567 @default.
• W2083278876 hasConceptScore W2083278876C2781252958 @default.
• W2083278876 hasConceptScore W2083278876C2781308076 @default.
• W2083278876 hasConceptScore W2083278876C38485361 @default.
• W2083278876 hasConceptScore W2083278876C48349386 @default.
• W2083278876 hasConceptScore W2083278876C55493867 @default.
• W2083278876 hasConceptScore W2083278876C75520062 @default.

• next