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- W2083283348 endingPage "544" @default.
- W2083283348 startingPage "536" @default.
- W2083283348 abstract "Copy-number variation (CNV) is the most prevalent type of structural variation in the human genome. There is emerging evidence that copy-number variants (CNVs) provide a new vista on understanding susceptibility to neuropsychiatric disorders. Some challenges in the interpretation of current CNV studies include the use of overlapping samples, differing phenotypic definitions, an absence of population norms for CNVs and a lack of consensus in methods for CNV detection and analysis. Here, we review current CNV association study methods and results in autism spectrum disorders (ASD) and schizophrenia, and provide suggestions for design approaches to future studies that might maximize the translation of this work to etiological understanding. Copy-number variation (CNV) is the most prevalent type of structural variation in the human genome. There is emerging evidence that copy-number variants (CNVs) provide a new vista on understanding susceptibility to neuropsychiatric disorders. Some challenges in the interpretation of current CNV studies include the use of overlapping samples, differing phenotypic definitions, an absence of population norms for CNVs and a lack of consensus in methods for CNV detection and analysis. Here, we review current CNV association study methods and results in autism spectrum disorders (ASD) and schizophrenia, and provide suggestions for design approaches to future studies that might maximize the translation of this work to etiological understanding." @default.
- W2083283348 created "2016-06-24" @default.
- W2083283348 creator A5000611339 @default.
- W2083283348 creator A5063304682 @default.
- W2083283348 creator A5091281664 @default.
- W2083283348 date "2009-12-01" @default.
- W2083283348 modified "2023-10-16" @default.
- W2083283348 title "Copy-number variants in neurodevelopmental disorders: promises and challenges" @default.
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