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• W2083284930 endingPage "576" @default.
• W2083284930 startingPage "569" @default.
• W2083284930 abstract "Cough is an indispensable defensive reflex. Although generally beneficial, cough is also a common symptom of diseases such as asthma, chronic obstructive pulmonary disease (COPD) and lung cancer. Cough remains a major unmet medical need and, although the centrally acting opioids have remained the antitussive drug of choice for decades, such opioids possess many unwanted side-effects. However, new research into the behaviour of airway sensory nerves has provided greater insight into the mechanisms of cough and new avenues for the discovery of novel non-opioid antitussive drugs. In this article, the pathophysiological mechanisms of cough and the implications of this research for the development of novel antitussive drugs will be discussed. A poster depicting the pharmacology of cough is available online and in print as supplementary material to this article. Cough is an indispensable defensive reflex. Although generally beneficial, cough is also a common symptom of diseases such as asthma, chronic obstructive pulmonary disease (COPD) and lung cancer. Cough remains a major unmet medical need and, although the centrally acting opioids have remained the antitussive drug of choice for decades, such opioids possess many unwanted side-effects. However, new research into the behaviour of airway sensory nerves has provided greater insight into the mechanisms of cough and new avenues for the discovery of novel non-opioid antitussive drugs. In this article, the pathophysiological mechanisms of cough and the implications of this research for the development of novel antitussive drugs will be discussed. A poster depicting the pharmacology of cough is available online and in print as supplementary material to this article. Erratum: The pharmacology of cough: 25 (2004), 569–576 et al.Trends in Pharmacological SciencesJanuary, 2005In BriefIn the article ‘The pharmacology of cough’ by Reynolds et al., which was published in the November 2004 issue of TiPS, there were three errors. In Box 1, sibenadet was incorrectly cited (in the text and table) as a dopamine D2 receptor and β2-adrenoceptor antagonist. It is in fact a D2 receptor and β2-adrenoceptor agonist. In the section ‘GABA receptors’ on p. 574, baclofen was incorrectly cited as a GABAB receptor antagonist. It is in fact a GABAB receptor agonist. In addition, Ref. 36 should have been cited as Adcock, J.J. Full-Text PDF" @default.
• W2083284930 created "2016-06-24" @default.
• W2083284930 creator A5034923280 @default.
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• W2083284930 date "2004-11-01" @default.
• W2083284930 modified "2023-09-30" @default.
• W2083284930 title "The pharmacology of cough" @default.
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