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- W2083289989 abstract "The sensitivity of platelets to adenosine diphosphate (ADP) was measured in a group of patients with occlusive peripheral atherosclerosis and the results were compared with those from apparently healthy normal subjects. Coagulation and lipoprotein measurements were also carried out in the two groups. In the patient group significantly higher values were obtained for the platelet response to ADP, (PAFP), the heparin-precipitable fraction of fibrinogen, plasma anti-heparin activity, plasma viscosity, ESR and partial thromboplastin clotting times as compared with the normal subjects. The mean value for the cholesterol-rich Sf 0–20 lipoproteins and the Sf 20–400 lipoproteins did not differ significantly between the groups. However in those patients who required surgery within a few weeks of the investigation significantly lower Sf 0–20 lipoprotein levels were found as compared with the levels in patients who only required conservative therapy. Analysis of the correlations between PAFP and the other parameters investigated suggested that in this type of patient PAFP was being influenced by similar factors to those producing disturbances in the blood coagulation mechanism. Multivariate analysis revealed a high degree of discrimination between the normal subjects and the patient group." @default.
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- W2083289989 title "Inter-relationships between platelet response to adenosine diphosphate, blood coagulation and serum lipids in patients with peripheral occlusive atherosclerosis" @default.
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- W2083289989 doi "https://doi.org/10.1016/0021-9150(72)90081-0" @default.
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