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• W2083307103 endingPage "20132174" @default.
• W2083307103 startingPage "20132174" @default.
• W2083307103 abstract "The rate of DNA mutation and divergence is highly variable across the tree of life. However, the reasons underlying this variation are not well understood. Comparing the rates of genetic changes between hosts and parasite lineages that diverged at the same time is one way to begin to understand differences in genetic mutation and substitution rates. Such studies have indicated that the rate of genetic divergence in parasites is often faster than that of their hosts when comparing single genes. However, the variation in this relative rate of molecular evolution across different genes in the genome is unknown. We compared the rate of DNA sequence divergence between humans, chimpanzees and their ectoparasitic lice for 1534 protein-coding genes across their genomes. The rate of DNA substitution in these orthologous genes was on average 14 times faster for lice than for humans and chimpanzees. In addition, these rates were positively correlated across genes. Because this correlation only occurred for substitutions that changed the amino acid, this pattern is probably produced by similar functional constraints across the same genes in humans, chimpanzees and their ectoparasites." @default.
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• W2083307103 date "2014-02-22" @default.
• W2083307103 modified "2023-09-27" @default.
• W2083307103 title "Rates of genomic divergence in humans, chimpanzees and their lice" @default.
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• W2083307103 doi "https://doi.org/10.1098/rspb.2013.2174" @default.
• W2083307103 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3896009" @default.
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