FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083313861> ?p ?o ?g. }

• W2083313861 endingPage "196" @default.
• W2083313861 startingPage "180" @default.
• W2083313861 abstract "Increasing chemical use necessitates a better understanding of how pollutants, such as di(2-ethylhexyl) phthalate (DEHP), a peroxisome proliferator and a phthalate plasticizer, affect human health. To understand the effects of DEHP exposure, we utilized microarray technology to identify novel DEHP targets in livers of male C57BL/6 mice treated with 1.0% dietary DEHP for 13 weeks. We identified 51 DEHP-regulated genes; these genes are involved in, but not limited to, peroxisome proliferation, xenobiotic detoxification, oxidative stress response, immune function, steroid hormone metabolism, testis development, and pheromone transport. The reproductive toxicity mechanism of DEHP may be due to its effects on steroid hormone metabolism and sexual development. Confirmation of microarray results with Northern blots demonstrated that both low- and high-dose DEHP treatments altered the expression of genes associated with testis development and steroid hormone synthesis. Vanin-1, a regulator of testis development, was upregulated after exposure to 0.2 and 1.0% DEHP by 1.8- and 2.9-fold, respectively. Several genes involved in hormone metabolism were also regulated by DEHP. 11betaHSDI was downregulated 1.8- and 3.1-fold by 0.2 and 1.0% DEHP, respectively, while HSD3b5 was suppressed similarly by 0.2% DEHP, 1.5-fold, and more severely by 1.0% DEHP, 8.0-fold. Interestingly, food restriction had a similar effect to DEHP on several genes, including HSD3b5. In addition, steroidogenic gene cyp7B1 was downregulated while phospholipid transfer protein and cyp2B9 were induced. Genes peripherally associated with steroid hormones were also affected: ALDH3, GSTtheta2, and Id2. Collectively, our data validate the concern for DEHP as a reproductive developmental toxicant." @default.
• W2083313861 created "2016-06-24" @default.
• W2083313861 creator A5077005270 @default.
• W2083313861 date "2002-12-15" @default.
• W2083313861 modified "2023-09-27" @default.
• W2083313861 title "Gene Expression Changes Induced in Mouse Liver by Di(2-ethylhexyl) Phthalate" @default.
• W2083313861 cites W1482096612 @default.
• W2083313861 cites W1554504884 @default.
• W2083313861 cites W1826473937 @default.
• W2083313861 cites W1899619333 @default.
• W2083313861 cites W1921083320 @default.
• W2083313861 cites W1962898688 @default.
• W2083313861 cites W1964613162 @default.
• W2083313861 cites W1968307951 @default.
• W2083313861 cites W1969061748 @default.
• W2083313861 cites W1980753827 @default.
• W2083313861 cites W1981152838 @default.
• W2083313861 cites W1994340375 @default.
• W2083313861 cites W1997060563 @default.
• W2083313861 cites W2001396094 @default.
• W2083313861 cites W2006802036 @default.
• W2083313861 cites W2008962413 @default.
• W2083313861 cites W2008998922 @default.
• W2083313861 cites W2014572827 @default.
• W2083313861 cites W2016727816 @default.
• W2083313861 cites W2018320895 @default.
• W2083313861 cites W2020426202 @default.
• W2083313861 cites W2024322918 @default.
• W2083313861 cites W2032985381 @default.
• W2083313861 cites W2035145734 @default.
• W2083313861 cites W2035666436 @default.
• W2083313861 cites W2036093969 @default.
• W2083313861 cites W2038187631 @default.
• W2083313861 cites W2039153579 @default.
• W2083313861 cites W2040851277 @default.
• W2083313861 cites W2043763182 @default.
• W2083313861 cites W2047517357 @default.
• W2083313861 cites W2048366203 @default.
• W2083313861 cites W2054739377 @default.
• W2083313861 cites W2060962226 @default.
• W2083313861 cites W2073417824 @default.
• W2083313861 cites W2080863653 @default.
• W2083313861 cites W2081152882 @default.
• W2083313861 cites W2081922333 @default.
• W2083313861 cites W2089958765 @default.
• W2083313861 cites W2092020543 @default.
• W2083313861 cites W2096787550 @default.
• W2083313861 cites W2097049516 @default.
• W2083313861 cites W2103280940 @default.
• W2083313861 cites W2110820845 @default.
• W2083313861 cites W2113328569 @default.
• W2083313861 cites W2119642891 @default.
• W2083313861 cites W2123836596 @default.
• W2083313861 cites W2123876698 @default.
• W2083313861 cites W2125734610 @default.
• W2083313861 cites W2134465607 @default.
• W2083313861 cites W2134779214 @default.
• W2083313861 cites W2137722420 @default.
• W2083313861 cites W2148492226 @default.
• W2083313861 cites W2150925908 @default.
• W2083313861 cites W2157936339 @default.
• W2083313861 cites W2165925659 @default.
• W2083313861 cites W2468186447 @default.
• W2083313861 cites W65694618 @default.
• W2083313861 doi "https://doi.org/10.1006/taap.2002.9540" @default.
• W2083313861 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12498735" @default.
• W2083313861 hasPublicationYear "2002" @default.
• W2083313861 type Work @default.
• W2083313861 sameAs 2083313861 @default.
• W2083313861 citedByCount "71" @default.
• W2083313861 countsByYear W20833138612012 @default.
• W2083313861 countsByYear W20833138612013 @default.
• W2083313861 countsByYear W20833138612014 @default.
• W2083313861 countsByYear W20833138612015 @default.
• W2083313861 countsByYear W20833138612016 @default.
• W2083313861 countsByYear W20833138612017 @default.
• W2083313861 countsByYear W20833138612018 @default.
• W2083313861 countsByYear W20833138612020 @default.
• W2083313861 countsByYear W20833138612021 @default.
• W2083313861 countsByYear W20833138612022 @default.
• W2083313861 countsByYear W20833138612023 @default.
• W2083313861 crossrefType "journal-article" @default.
• W2083313861 hasAuthorship W2083313861A5077005270 @default.
• W2083313861 hasConcept C126322002 @default.
• W2083313861 hasConcept C134018914 @default.
• W2083313861 hasConcept C178790620 @default.
• W2083313861 hasConcept C185592680 @default.
• W2083313861 hasConcept C2776888042 @default.
• W2083313861 hasConcept C2780902042 @default.
• W2083313861 hasConcept C2781005124 @default.
• W2083313861 hasConcept C29730261 @default.
• W2083313861 hasConcept C3020590458 @default.
• W2083313861 hasConcept C4733338 @default.
• W2083313861 hasConcept C71315377 @default.
• W2083313861 hasConcept C71924100 @default.
• W2083313861 hasConcept C86803240 @default.
• W2083313861 hasConcept C99432707 @default.
• W2083313861 hasConceptScore W2083313861C126322002 @default.

• next