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- W2083315575 abstract "Abstract Macromomycin, an antitumor protein, after purification inhibited HeLa S 3 cell growth at low nanomolar concentrations. DNA synthesis was inhibited at drug levels that left RNA and protein synthesis unaffected. Incubation of macromomycin with HeLa S 3 cells resulted in a rapid fragmentation of cellular DNA that was detectable at low nanomolar drug levels. Heat denaturation of macromomycin showed that both its ability to inhibit cell growth and to fragment cellular DNA were lost at similar rates." @default.
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- W2083315575 date "1978-08-01" @default.
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- W2083315575 title "Cellular DNA damage by the antitumor protein macromomycin and its relationship to cell growth inhibition" @default.
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- W2083315575 doi "https://doi.org/10.1016/0006-291x(78)91481-x" @default.
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