Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083319614> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2083319614 abstract "The in vivo efficacy of 25.3 monoclonal antibody (mAb) directed against human LFA1 molecule was assessed in ten patients with steroid-resistant grade III-IV acute graft-versus-host disease (AGVHD). These patients received non-T-cell-depleted allogeneic bone marrow transplantation for aplastic anemia in two cases and hematologic malignancies in eight cases. Five grafts were fully matched, three were one antigen-mismatched, and two were two antigen-mismatched. Despite GVHD prophylaxis with cyclosporin A and short-term methotrexate, AGVHD occurred after a median of 24 days and clearly progressed under prednisone (median 2 mg/kg), given for a median of 12 days. 25.3 mAb was given at a dosage of 0.1 mg/kg in a 4-h perfusion for five daily doses without any clinical or biological side effects. Thirty percent of the patients experienced a reduction in the overall grading with two complete responses. Partial response in at least one involved organ (mostly skin) occurred in 80% of the patients. However, seven out of the eight responding patients experienced a new episode of AGVHD. This observation, which confirms that inhibiting a functional molecule is as efficient as a cytolytic therapy, offers an alternative strategy to antithymocyte globulin (ATG) and cytotoxic mAb in controlling steroid-resistant GVHD." @default.
- W2083319614 created "2016-06-24" @default.
- W2083319614 creator A5009364522 @default.
- W2083319614 creator A5018420751 @default.
- W2083319614 creator A5020056942 @default.
- W2083319614 creator A5022161221 @default.
- W2083319614 creator A5029679351 @default.
- W2083319614 creator A5032703463 @default.
- W2083319614 creator A5034473496 @default.
- W2083319614 creator A5052078738 @default.
- W2083319614 creator A5058334809 @default.
- W2083319614 creator A5077863801 @default.
- W2083319614 date "1991-04-01" @default.
- W2083319614 modified "2023-09-27" @default.
- W2083319614 title "Anti-LFA1 monoclonal antibody (25.3) for treatment of steroid-resistant grade III?IV acute graft-versus-host disease" @default.
- W2083319614 cites W2003272849 @default.
- W2083319614 cites W2020681820 @default.
- W2083319614 cites W2023497948 @default.
- W2083319614 cites W2028248911 @default.
- W2083319614 cites W2032549221 @default.
- W2083319614 cites W2043307123 @default.
- W2083319614 cites W2052588416 @default.
- W2083319614 cites W2074576427 @default.
- W2083319614 cites W2084886561 @default.
- W2083319614 cites W2088337552 @default.
- W2083319614 cites W2105506999 @default.
- W2083319614 cites W2115232902 @default.
- W2083319614 cites W2151588959 @default.
- W2083319614 cites W2166481461 @default.
- W2083319614 cites W2337969406 @default.
- W2083319614 cites W33772365 @default.
- W2083319614 cites W5387557 @default.
- W2083319614 cites W95208818 @default.
- W2083319614 doi "https://doi.org/10.1007/bf00335508" @default.
- W2083319614 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2059297" @default.
- W2083319614 hasPublicationYear "1991" @default.
- W2083319614 type Work @default.
- W2083319614 sameAs 2083319614 @default.
- W2083319614 citedByCount "13" @default.
- W2083319614 countsByYear W20833196142017 @default.
- W2083319614 crossrefType "journal-article" @default.
- W2083319614 hasAuthorship W2083319614A5009364522 @default.
- W2083319614 hasAuthorship W2083319614A5018420751 @default.
- W2083319614 hasAuthorship W2083319614A5020056942 @default.
- W2083319614 hasAuthorship W2083319614A5022161221 @default.
- W2083319614 hasAuthorship W2083319614A5029679351 @default.
- W2083319614 hasAuthorship W2083319614A5032703463 @default.
- W2083319614 hasAuthorship W2083319614A5034473496 @default.
- W2083319614 hasAuthorship W2083319614A5052078738 @default.
- W2083319614 hasAuthorship W2083319614A5058334809 @default.
- W2083319614 hasAuthorship W2083319614A5077863801 @default.
- W2083319614 hasConcept C126322002 @default.
- W2083319614 hasConcept C147483822 @default.
- W2083319614 hasConcept C159654299 @default.
- W2083319614 hasConcept C203014093 @default.
- W2083319614 hasConcept C2778720950 @default.
- W2083319614 hasConcept C2779972918 @default.
- W2083319614 hasConcept C2780007613 @default.
- W2083319614 hasConcept C2781059491 @default.
- W2083319614 hasConcept C2781440808 @default.
- W2083319614 hasConcept C2911091166 @default.
- W2083319614 hasConcept C542903549 @default.
- W2083319614 hasConcept C71924100 @default.
- W2083319614 hasConcept C90924648 @default.
- W2083319614 hasConceptScore W2083319614C126322002 @default.
- W2083319614 hasConceptScore W2083319614C147483822 @default.
- W2083319614 hasConceptScore W2083319614C159654299 @default.
- W2083319614 hasConceptScore W2083319614C203014093 @default.
- W2083319614 hasConceptScore W2083319614C2778720950 @default.
- W2083319614 hasConceptScore W2083319614C2779972918 @default.
- W2083319614 hasConceptScore W2083319614C2780007613 @default.
- W2083319614 hasConceptScore W2083319614C2781059491 @default.
- W2083319614 hasConceptScore W2083319614C2781440808 @default.
- W2083319614 hasConceptScore W2083319614C2911091166 @default.
- W2083319614 hasConceptScore W2083319614C542903549 @default.
- W2083319614 hasConceptScore W2083319614C71924100 @default.
- W2083319614 hasConceptScore W2083319614C90924648 @default.
- W2083319614 hasLocation W20833196141 @default.
- W2083319614 hasLocation W20833196142 @default.
- W2083319614 hasOpenAccess W2083319614 @default.
- W2083319614 hasPrimaryLocation W20833196141 @default.
- W2083319614 hasRelatedWork W1560856437 @default.
- W2083319614 hasRelatedWork W1964099284 @default.
- W2083319614 hasRelatedWork W2018662028 @default.
- W2083319614 hasRelatedWork W2052403909 @default.
- W2083319614 hasRelatedWork W2406718099 @default.
- W2083319614 hasRelatedWork W2418101875 @default.
- W2083319614 hasRelatedWork W2461055654 @default.
- W2083319614 hasRelatedWork W4235025700 @default.
- W2083319614 hasRelatedWork W4246145878 @default.
- W2083319614 hasRelatedWork W288081102 @default.
- W2083319614 isParatext "false" @default.
- W2083319614 isRetracted "false" @default.
- W2083319614 magId "2083319614" @default.
- W2083319614 workType "article" @default.