FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083320362> ?p ?o ?g. }

• W2083320362 endingPage "e21185" @default.
• W2083320362 startingPage "e21185" @default.
• W2083320362 abstract "Both endothelial and immune dysfunction contribute to the high mortality rate in human sepsis, but the underlying mechanisms are unclear. In response to infection, interferon-γ activates indoleamine 2,3-dioxygenase (IDO) which metabolizes the essential amino acid tryptophan to the toxic metabolite kynurenine. IDO can be expressed in endothelial cells, hepatocytes and mononuclear leukocytes, all of which contribute to sepsis pathophysiology. Increased IDO activity (measured by the kynurenine to tryptophan [KT] ratio in plasma) causes T-cell apoptosis, vasodilation and nitric oxide synthase inhibition. We hypothesized that IDO activity in sepsis would be related to plasma interferon-γ, interleukin-10, T cell lymphopenia and impairment of microvascular reactivity, a measure of endothelial nitric oxide bioavailability. In an observational cohort study of 80 sepsis patients (50 severe and 30 non-severe) and 40 hospital controls, we determined the relationship between IDO activity (plasma KT ratio) and selected plasma cytokines, sepsis severity, nitric oxide-dependent microvascular reactivity and lymphocyte subsets in sepsis. Plasma amino acids were measured by high performance liquid chromatography and microvascular reactivity by peripheral arterial tonometry. The plasma KT ratio was increased in sepsis (median 141 [IQR 64-235]) compared to controls (36 [28-52]); p<0.0001), and correlated with plasma interferon-γ and interleukin-10, and inversely with total lymphocyte count, CD8+ and CD4+ T-lymphocytes, systolic blood pressure and microvascular reactivity. In response to treatment of severe sepsis, the median KT ratio decreased from 162 [IQR 100-286] on day 0 to 89 [65-139] by day 7; p = 0.0006) and this decrease in KT ratio correlated with a decrease in the Sequential Organ Failure Assessment score (p<0.0001). IDO-mediated tryptophan catabolism is associated with dysregulated immune responses and impaired microvascular reactivity in sepsis and may link these two fundamental processes in sepsis pathophysiology." @default.
• W2083320362 created "2016-06-24" @default.
• W2083320362 creator A5018302660 @default.
• W2083320362 creator A5023103534 @default.
• W2083320362 creator A5032095213 @default.
• W2083320362 creator A5064616987 @default.
• W2083320362 creator A5080405122 @default.
• W2083320362 creator A5083109502 @default.
• W2083320362 creator A5089350667 @default.
• W2083320362 date "2011-06-22" @default.
• W2083320362 modified "2023-09-26" @default.
• W2083320362 title "An Observational Cohort Study of the Kynurenine to Tryptophan Ratio in Sepsis: Association with Impaired Immune and Microvascular Function" @default.
• W2083320362 cites W1488866398 @default.
• W2083320362 cites W1499659307 @default.
• W2083320362 cites W1512372665 @default.
• W2083320362 cites W1519089655 @default.
• W2083320362 cites W1545509462 @default.
• W2083320362 cites W154934337 @default.
• W2083320362 cites W1849785625 @default.
• W2083320362 cites W1856680566 @default.
• W2083320362 cites W1895819679 @default.
• W2083320362 cites W1941269409 @default.
• W2083320362 cites W1965240438 @default.
• W2083320362 cites W1967706256 @default.
• W2083320362 cites W1968651366 @default.
• W2083320362 cites W1971900958 @default.
• W2083320362 cites W1975763557 @default.
• W2083320362 cites W1977905350 @default.
• W2083320362 cites W1982163811 @default.
• W2083320362 cites W1983379130 @default.
• W2083320362 cites W1984653919 @default.
• W2083320362 cites W1987171603 @default.
• W2083320362 cites W1988941798 @default.
• W2083320362 cites W1991864206 @default.
• W2083320362 cites W1995162162 @default.
• W2083320362 cites W2000851646 @default.
• W2083320362 cites W2003635644 @default.
• W2083320362 cites W2010343273 @default.
• W2083320362 cites W2013792518 @default.
• W2083320362 cites W2014644469 @default.
• W2083320362 cites W2022430924 @default.
• W2083320362 cites W2022562613 @default.
• W2083320362 cites W2024565627 @default.
• W2083320362 cites W2029458048 @default.
• W2083320362 cites W2034981483 @default.
• W2083320362 cites W2039022182 @default.
• W2083320362 cites W2045266280 @default.
• W2083320362 cites W2046060950 @default.
• W2083320362 cites W2048046456 @default.
• W2083320362 cites W2049927822 @default.
• W2083320362 cites W2050779943 @default.
• W2083320362 cites W2051839360 @default.
• W2083320362 cites W2052320808 @default.
• W2083320362 cites W2052374541 @default.
• W2083320362 cites W2056778604 @default.
• W2083320362 cites W2061402985 @default.
• W2083320362 cites W2067540228 @default.
• W2083320362 cites W2068535052 @default.
• W2083320362 cites W2070743921 @default.
• W2083320362 cites W2072078248 @default.
• W2083320362 cites W2073965239 @default.
• W2083320362 cites W2074671063 @default.
• W2083320362 cites W2078337849 @default.
• W2083320362 cites W2093666338 @default.
• W2083320362 cites W2095497639 @default.
• W2083320362 cites W2103568206 @default.
• W2083320362 cites W2106413142 @default.
• W2083320362 cites W2107662475 @default.
• W2083320362 cites W2109207751 @default.
• W2083320362 cites W2116742245 @default.
• W2083320362 cites W2119939110 @default.
• W2083320362 cites W2122055987 @default.
• W2083320362 cites W2122285073 @default.
• W2083320362 cites W2123735453 @default.
• W2083320362 cites W2124858924 @default.
• W2083320362 cites W2131301672 @default.
• W2083320362 cites W2132621122 @default.
• W2083320362 cites W2134987998 @default.
• W2083320362 cites W2140657592 @default.
• W2083320362 cites W2141868068 @default.
• W2083320362 cites W2158544309 @default.
• W2083320362 cites W2163828684 @default.
• W2083320362 cites W2171437874 @default.
• W2083320362 cites W2417051390 @default.
• W2083320362 cites W2768146862 @default.
• W2083320362 doi "https://doi.org/10.1371/journal.pone.0021185" @default.
• W2083320362 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3120841" @default.
• W2083320362 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21731667" @default.
• W2083320362 hasPublicationYear "2011" @default.
• W2083320362 type Work @default.
• W2083320362 sameAs 2083320362 @default.
• W2083320362 citedByCount "68" @default.
• W2083320362 countsByYear W20833203622012 @default.
• W2083320362 countsByYear W20833203622013 @default.
• W2083320362 countsByYear W20833203622014 @default.
• W2083320362 countsByYear W20833203622015 @default.
• W2083320362 countsByYear W20833203622016 @default.
• W2083320362 countsByYear W20833203622017 @default.

• next