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- W2083325648 abstract "We found that K252a, a potent inhibitor of protein kinases (PK), induced DNA rereplication of Meth-A cells, i.e., DNA synthesis at a higher DNA ploidy without undergoing cytokinesis (polyploidization). The K252a-induced polyploidization was inhibited by phorbol 12-myristate 13-acetate (PMA), a protein kinase C (PKC) activator, suggesting that the polyploidization is caused through inhibition of PKC. By contrast, the polyploidization was potentiated by adenosine 3′:5′-cyclic monophosphate (cAMP), a cAMP-dependent protein kinase (PKA) activator. These findings suggest that the cAMP-dependent signaling pathway and diacylglycerol (DAG)-dependent signaling pathway play an important role in regulating the induction of polyploidization in Meth-A cells, through a possible cross-talk between the two pathways." @default.
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- W2083325648 date "1994-11-01" @default.
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- W2083325648 title "Potentiation of K252a, a Protein-Kinase Inhibitor-Induced Polyploidization by cAMP in Cultured Fibrosarcoma Cell Line" @default.
- W2083325648 doi "https://doi.org/10.1006/bbrc.1994.2728" @default.
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