FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083332661> ?p ?o ?g. }

• W2083332661 endingPage "13989" @default.
• W2083332661 startingPage "13981" @default.
• W2083332661 abstract "ABSTRACT Bluetongue virus serotype 1 (BTV 1) was first isolated in Australia from cattle blood collected in 1979 at Beatrice Hill Farm (BHF), Northern Territory (NT). From long-term surveillance programs (1977 to 2011), 2,487 isolations of 10 BTV serotypes were made. The most frequently isolated serotype was BTV 1 (41%, 1,019) followed by BTV 16 (17.5%, 436) and BTV 20 (14%, 348). In 3 years, no BTVs were isolated, and in 12 years, no BTV 1 was isolated. Seventeen BTV 1 isolates were sequenced and analyzed in comparison with 10 Australian prototype serotypes. BTV 1 showed an episodic pattern of evolutionary change characterized by four distinct periods. Each period consisted primarily of slow genetic drift which was punctuated from time to time by genetic shifts generated by segment reassortment and the introduction of new genome segments. Evidence was found for coevolution of BTV genome segments. Evolutionary dynamics and selection pressure estimates showed strong temporal and clock-like molecular evolutionary dynamics of six Australian BTV genome segments. Bayesian coalescent estimates of mean substitution rates clustered in the range of 3.5 × 10 −4 to 5.3 × 10 −4 substitutions per site per year. All BTV genome segments evolved under strong purifying (negative) selection, with only three sites identified as under pervasive diversifying (positive) selection. The obligate replication in alternate hosts (insect vector and vertebrate hosts) imposed strong evolutionary constraints. The dominant mechanism generating genetic diversity of BTV 1 at BHF was through the introduction of new viruses and reassortment of genome segments with existing viruses. IMPORTANCE Bluetongue virus (BTV) is the causative agent of bluetongue disease in ruminants. It is a disease of concern globally and is transmitted by biting midges ( Culicoides species). Analysis of the evolutionary and selection pressures on BTV 1 at a single surveillance site in northern Australia showed strong temporal and clock-like dynamics. Obligate replication in alternate hosts of insect and vertebrate imposed strong evolutionary constraints, with all BTV genome segments evolving under strong purifying (negative) selection. Generation of genetic diversity of BTV 1 in northern Australia is through genome segment reassortment and the introduction of new serotypes." @default.
• W2083332661 created "2016-06-24" @default.
• W2083332661 creator A5008687267 @default.
• W2083332661 creator A5019585658 @default.
• W2083332661 creator A5031417440 @default.
• W2083332661 creator A5037546307 @default.
• W2083332661 creator A5048672169 @default.
• W2083332661 creator A5060050628 @default.
• W2083332661 creator A5062534507 @default.
• W2083332661 creator A5075794320 @default.
• W2083332661 creator A5078180271 @default.
• W2083332661 date "2014-12-15" @default.
• W2083332661 modified "2023-10-09" @default.
• W2083332661 title "Evolution of Bluetongue Virus Serotype 1 in Northern Australia over 30 Years" @default.
• W2083332661 cites W1574951703 @default.
• W2083332661 cites W1968188888 @default.
• W2083332661 cites W1970599175 @default.
• W2083332661 cites W1984038725 @default.
• W2083332661 cites W1988660043 @default.
• W2083332661 cites W1996028819 @default.
• W2083332661 cites W2020083042 @default.
• W2083332661 cites W2020939898 @default.
• W2083332661 cites W2030862217 @default.
• W2083332661 cites W2035952255 @default.
• W2083332661 cites W2038360005 @default.
• W2083332661 cites W2041518831 @default.
• W2083332661 cites W2041592632 @default.
• W2083332661 cites W2060425093 @default.
• W2083332661 cites W2061603739 @default.
• W2083332661 cites W2063682114 @default.
• W2083332661 cites W2067015758 @default.
• W2083332661 cites W2067343287 @default.
• W2083332661 cites W2068687644 @default.
• W2083332661 cites W2077384616 @default.
• W2083332661 cites W2079656551 @default.
• W2083332661 cites W2081606079 @default.
• W2083332661 cites W2107858431 @default.
• W2083332661 cites W2130362098 @default.
• W2083332661 cites W2132632499 @default.
• W2083332661 cites W2132982999 @default.
• W2083332661 cites W2134213231 @default.
• W2083332661 cites W2140028978 @default.
• W2083332661 cites W2141008678 @default.
• W2083332661 cites W2144481684 @default.
• W2083332661 cites W2146602601 @default.
• W2083332661 cites W2153527981 @default.
• W2083332661 cites W2154384871 @default.
• W2083332661 cites W2158207916 @default.
• W2083332661 cites W2159283632 @default.
• W2083332661 cites W2160969485 @default.
• W2083332661 cites W2163921672 @default.
• W2083332661 cites W2164680781 @default.
• W2083332661 cites W2166895915 @default.
• W2083332661 cites W2170885291 @default.
• W2083332661 doi "https://doi.org/10.1128/jvi.02055-14" @default.
• W2083332661 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4249141" @default.
• W2083332661 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25253345" @default.
• W2083332661 hasPublicationYear "2014" @default.
• W2083332661 type Work @default.
• W2083332661 sameAs 2083332661 @default.
• W2083332661 citedByCount "23" @default.
• W2083332661 countsByYear W20833326612015 @default.
• W2083332661 countsByYear W20833326612016 @default.
• W2083332661 countsByYear W20833326612017 @default.
• W2083332661 countsByYear W20833326612018 @default.
• W2083332661 countsByYear W20833326612019 @default.
• W2083332661 countsByYear W20833326612020 @default.
• W2083332661 countsByYear W20833326612021 @default.
• W2083332661 countsByYear W20833326612022 @default.
• W2083332661 countsByYear W20833326612023 @default.
• W2083332661 crossrefType "journal-article" @default.
• W2083332661 hasAuthorship W2083332661A5008687267 @default.
• W2083332661 hasAuthorship W2083332661A5019585658 @default.
• W2083332661 hasAuthorship W2083332661A5031417440 @default.
• W2083332661 hasAuthorship W2083332661A5037546307 @default.
• W2083332661 hasAuthorship W2083332661A5048672169 @default.
• W2083332661 hasAuthorship W2083332661A5060050628 @default.
• W2083332661 hasAuthorship W2083332661A5062534507 @default.
• W2083332661 hasAuthorship W2083332661A5075794320 @default.
• W2083332661 hasAuthorship W2083332661A5078180271 @default.
• W2083332661 hasBestOaLocation W20833326612 @default.
• W2083332661 hasConcept C10389963 @default.
• W2083332661 hasConcept C104317684 @default.
• W2083332661 hasConcept C141231307 @default.
• W2083332661 hasConcept C142724271 @default.
• W2083332661 hasConcept C144024400 @default.
• W2083332661 hasConcept C149923435 @default.
• W2083332661 hasConcept C159047783 @default.
• W2083332661 hasConcept C16154277 @default.
• W2083332661 hasConcept C171578705 @default.
• W2083332661 hasConcept C193252679 @default.
• W2083332661 hasConcept C196662502 @default.
• W2083332661 hasConcept C2554327 @default.
• W2083332661 hasConcept C2776817793 @default.
• W2083332661 hasConcept C2779134260 @default.
• W2083332661 hasConcept C2780399816 @default.
• W2083332661 hasConcept C2908647359 @default.
• W2083332661 hasConcept C3008058167 @default.

• next