FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083334071> ?p ?o ?g. }

• W2083334071 endingPage "497" @default.
• W2083334071 startingPage "493" @default.
• W2083334071 abstract "Mitochondrial impairment has been collecting more and more attention as a contributing factor to the etiology of Parkinson's disease. Above all, the NADH-quinone oxidoreductase, complex I, of the respiratory chain seems to be most culpable. Complex I dysfunction is translated to an increased production of reactive oxygen species and a decreased energy supply. In the brain, the dopaminergic neurons are one of the most susceptible cells. Their death is directly linked to the disease apparition. Developing an effective gene therapy is challenged by harmful actions of reactive oxygen species. To overcome this problem a therapeutic candidate must be able to restore the NADH-quinone oxidoreductase activity regardless of how complex I is impaired. Here we discuss the potency of the yeast alternative NADH dehydrogenase, the Ndi1 protein, to reinstate the mitochondrial respiratory chain compensating for disabled complex I and the benefit Ndi1 brings toward retardation of Parkinson's disease." @default.
• W2083334071 created "2016-06-24" @default.
• W2083334071 creator A5018615904 @default.
• W2083334071 creator A5026936772 @default.
• W2083334071 creator A5030605627 @default.
• W2083334071 creator A5078761956 @default.
• W2083334071 date "2009-11-11" @default.
• W2083334071 modified "2023-09-27" @default.
• W2083334071 title "Parkinson’s disease and mitochondrial complex I: a perspective on the Ndi1 therapy" @default.
• W2083334071 cites W1504584187 @default.
• W2083334071 cites W1602098835 @default.
• W2083334071 cites W1902946357 @default.
• W2083334071 cites W1964364573 @default.
• W2083334071 cites W1969205203 @default.
• W2083334071 cites W1985917760 @default.
• W2083334071 cites W1991511436 @default.
• W2083334071 cites W1997757821 @default.
• W2083334071 cites W2009294443 @default.
• W2083334071 cites W2029009175 @default.
• W2083334071 cites W2033909906 @default.
• W2083334071 cites W2042712894 @default.
• W2083334071 cites W2045416175 @default.
• W2083334071 cites W2046070170 @default.
• W2083334071 cites W2067293718 @default.
• W2083334071 cites W2072858840 @default.
• W2083334071 cites W2077260129 @default.
• W2083334071 cites W2083142775 @default.
• W2083334071 cites W2085723420 @default.
• W2083334071 cites W2112777355 @default.
• W2083334071 cites W2128033750 @default.
• W2083334071 cites W2136388422 @default.
• W2083334071 cites W2140647923 @default.
• W2083334071 cites W2143959688 @default.
• W2083334071 cites W2153582938 @default.
• W2083334071 cites W2171873547 @default.
• W2083334071 cites W2792448780 @default.
• W2083334071 doi "https://doi.org/10.1007/s10863-009-9249-z" @default.
• W2083334071 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2924754" @default.
• W2083334071 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19904590" @default.
• W2083334071 hasPublicationYear "2009" @default.
• W2083334071 type Work @default.
• W2083334071 sameAs 2083334071 @default.
• W2083334071 citedByCount "56" @default.
• W2083334071 countsByYear W20833340712012 @default.
• W2083334071 countsByYear W20833340712013 @default.
• W2083334071 countsByYear W20833340712014 @default.
• W2083334071 countsByYear W20833340712015 @default.
• W2083334071 countsByYear W20833340712017 @default.
• W2083334071 countsByYear W20833340712018 @default.
• W2083334071 countsByYear W20833340712019 @default.
• W2083334071 countsByYear W20833340712020 @default.
• W2083334071 countsByYear W20833340712021 @default.
• W2083334071 countsByYear W20833340712022 @default.
• W2083334071 countsByYear W20833340712023 @default.
• W2083334071 crossrefType "journal-article" @default.
• W2083334071 hasAuthorship W2083334071A5018615904 @default.
• W2083334071 hasAuthorship W2083334071A5026936772 @default.
• W2083334071 hasAuthorship W2083334071A5030605627 @default.
• W2083334071 hasAuthorship W2083334071A5078761956 @default.
• W2083334071 hasBestOaLocation W20833340712 @default.
• W2083334071 hasConcept C104317684 @default.
• W2083334071 hasConcept C126322002 @default.
• W2083334071 hasConcept C137183658 @default.
• W2083334071 hasConcept C169760540 @default.
• W2083334071 hasConcept C181199279 @default.
• W2083334071 hasConcept C24586158 @default.
• W2083334071 hasConcept C2776319529 @default.
• W2083334071 hasConcept C2779134260 @default.
• W2083334071 hasConcept C2779268744 @default.
• W2083334071 hasConcept C2779734285 @default.
• W2083334071 hasConcept C28859421 @default.
• W2083334071 hasConcept C2909692557 @default.
• W2083334071 hasConcept C3020377403 @default.
• W2083334071 hasConcept C3020761558 @default.
• W2083334071 hasConcept C48349386 @default.
• W2083334071 hasConcept C513476851 @default.
• W2083334071 hasConcept C55493867 @default.
• W2083334071 hasConcept C71924100 @default.
• W2083334071 hasConcept C86803240 @default.
• W2083334071 hasConceptScore W2083334071C104317684 @default.
• W2083334071 hasConceptScore W2083334071C126322002 @default.
• W2083334071 hasConceptScore W2083334071C137183658 @default.
• W2083334071 hasConceptScore W2083334071C169760540 @default.
• W2083334071 hasConceptScore W2083334071C181199279 @default.
• W2083334071 hasConceptScore W2083334071C24586158 @default.
• W2083334071 hasConceptScore W2083334071C2776319529 @default.
• W2083334071 hasConceptScore W2083334071C2779134260 @default.
• W2083334071 hasConceptScore W2083334071C2779268744 @default.
• W2083334071 hasConceptScore W2083334071C2779734285 @default.
• W2083334071 hasConceptScore W2083334071C28859421 @default.
• W2083334071 hasConceptScore W2083334071C2909692557 @default.
• W2083334071 hasConceptScore W2083334071C3020377403 @default.
• W2083334071 hasConceptScore W2083334071C3020761558 @default.
• W2083334071 hasConceptScore W2083334071C48349386 @default.
• W2083334071 hasConceptScore W2083334071C513476851 @default.
• W2083334071 hasConceptScore W2083334071C55493867 @default.
• W2083334071 hasConceptScore W2083334071C71924100 @default.
• W2083334071 hasConceptScore W2083334071C86803240 @default.

• next