FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083334972> ?p ?o ?g. }

• W2083334972 endingPage "905" @default.
• W2083334972 startingPage "896" @default.
• W2083334972 abstract "Summary Gain-of-function mutation in Nav1.8 channel produces its most marked effect along the axon, resulting in intense spontaneous bursting and increased mechanically evoked action potentials in specific afferent subpopulations. Therapeutic use of general sodium channel blockers, such as lidocaine, can substantially reduce the enhanced activity in sensory neurons that accompanies chronic pain after nerve or tissue injury. However, because these general blockers have significant side effects, there is great interest in developing inhibitors that specifically target subtypes of sodium channels. Moreover, some idiopathic small-fiber neuropathies are driven by gain-of-function mutations in specific sodium channel subtypes. In the current study, we focus on one subtype, the voltage-gated sodium channel 1.8 (Nav1.8). Nav1.8 is preferentially expressed in nociceptors, and gain-of-function mutations in Nav1.8 result in painful mechanical hypersensitivity in humans. Here, we used the recently developed gain-of-function Nav1.8 transgenic mouse strain, Possum, to investigate Nav1.8-mediated peripheral afferent hyperexcitability. This gain-of-function mutation resulted in markedly increased mechanically evoked action potential firing in subclasses of Aβ, Aδ, and C fibers. Moreover, mechanical stimuli initiated bursts of action potential firing in specific subpopulations that continued for minutes after removal of the force and were not susceptible to conduction failure. Surprisingly, despite the intense afferent firing, the behavioral effects of the Nav1.8 mutation were quite modest, as only frankly noxious stimuli elicited enhanced pain behavior. These data demonstrate that a Nav1.8 gain-of-function point mutation contributes to intense hyperexcitability along the afferent axon within distinct sensory neuron subtypes." @default.
• W2083334972 created "2016-06-24" @default.
• W2083334972 creator A5028617616 @default.
• W2083334972 creator A5059140393 @default.
• W2083334972 creator A5078351705 @default.
• W2083334972 creator A5088325043 @default.
• W2083334972 creator A5090596131 @default.
• W2083334972 date "2014-05-01" @default.
• W2083334972 modified "2023-09-27" @default.
• W2083334972 title "A gain-of-function voltage-gated sodium channel 1.8 mutation drives intense hyperexcitability of A- and C-fiber neurons" @default.
• W2083334972 cites W1481443370 @default.
• W2083334972 cites W1544886753 @default.
• W2083334972 cites W1549160512 @default.
• W2083334972 cites W1592184520 @default.
• W2083334972 cites W1596758664 @default.
• W2083334972 cites W1748186601 @default.
• W2083334972 cites W1965887065 @default.
• W2083334972 cites W1982096814 @default.
• W2083334972 cites W1986661851 @default.
• W2083334972 cites W1995283627 @default.
• W2083334972 cites W1996697190 @default.
• W2083334972 cites W1997333327 @default.
• W2083334972 cites W1997559144 @default.
• W2083334972 cites W1998175588 @default.
• W2083334972 cites W1999040914 @default.
• W2083334972 cites W2003963645 @default.
• W2083334972 cites W2004938469 @default.
• W2083334972 cites W2007944782 @default.
• W2083334972 cites W2008465842 @default.
• W2083334972 cites W2013173477 @default.
• W2083334972 cites W2013514756 @default.
• W2083334972 cites W2026551512 @default.
• W2083334972 cites W2029105646 @default.
• W2083334972 cites W2035257142 @default.
• W2083334972 cites W2049710812 @default.
• W2083334972 cites W2052661167 @default.
• W2083334972 cites W2063835667 @default.
• W2083334972 cites W2073293886 @default.
• W2083334972 cites W2074027763 @default.
• W2083334972 cites W2074538274 @default.
• W2083334972 cites W2077341935 @default.
• W2083334972 cites W2077392459 @default.
• W2083334972 cites W2080764042 @default.
• W2083334972 cites W2083107042 @default.
• W2083334972 cites W2090068017 @default.
• W2083334972 cites W2092511662 @default.
• W2083334972 cites W2103351070 @default.
• W2083334972 cites W2135531905 @default.
• W2083334972 cites W2137712740 @default.
• W2083334972 cites W2138839177 @default.
• W2083334972 cites W2151756831 @default.
• W2083334972 cites W2154417052 @default.
• W2083334972 cites W2156289861 @default.
• W2083334972 cites W2157583691 @default.
• W2083334972 cites W2162056974 @default.
• W2083334972 cites W2162723169 @default.
• W2083334972 cites W2172201406 @default.
• W2083334972 cites W2202794054 @default.
• W2083334972 cites W2336932349 @default.
• W2083334972 cites W40340874 @default.
• W2083334972 cites W965296396 @default.
• W2083334972 doi "https://doi.org/10.1016/j.pain.2014.01.012" @default.
• W2083334972 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3989381" @default.
• W2083334972 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24447515" @default.
• W2083334972 hasPublicationYear "2014" @default.
• W2083334972 type Work @default.
• W2083334972 sameAs 2083334972 @default.
• W2083334972 citedByCount "35" @default.
• W2083334972 countsByYear W20833349722014 @default.
• W2083334972 countsByYear W20833349722015 @default.
• W2083334972 countsByYear W20833349722016 @default.
• W2083334972 countsByYear W20833349722017 @default.
• W2083334972 countsByYear W20833349722018 @default.
• W2083334972 countsByYear W20833349722019 @default.
• W2083334972 countsByYear W20833349722020 @default.
• W2083334972 countsByYear W20833349722021 @default.
• W2083334972 countsByYear W20833349722022 @default.
• W2083334972 countsByYear W20833349722023 @default.
• W2083334972 crossrefType "journal-article" @default.
• W2083334972 hasAuthorship W2083334972A5028617616 @default.
• W2083334972 hasAuthorship W2083334972A5059140393 @default.
• W2083334972 hasAuthorship W2083334972A5078351705 @default.
• W2083334972 hasAuthorship W2083334972A5088325043 @default.
• W2083334972 hasAuthorship W2083334972A5090596131 @default.
• W2083334972 hasBestOaLocation W20833349722 @default.
• W2083334972 hasConcept C126322002 @default.
• W2083334972 hasConcept C15490471 @default.
• W2083334972 hasConcept C169760540 @default.
• W2083334972 hasConcept C170493617 @default.
• W2083334972 hasConcept C172659308 @default.
• W2083334972 hasConcept C178790620 @default.
• W2083334972 hasConcept C185592680 @default.
• W2083334972 hasConcept C2776414672 @default.
• W2083334972 hasConcept C2776625714 @default.
• W2083334972 hasConcept C2777589315 @default.
• W2083334972 hasConcept C50952357 @default.
• W2083334972 hasConcept C537181965 @default.
• W2083334972 hasConcept C71924100 @default.

• next