FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083337020> ?p ?o ?g. }

• W2083337020 endingPage "737" @default.
• W2083337020 startingPage "727" @default.
• W2083337020 abstract "Tumor cells are characterized by their loss of growth control resulting from alterations in regulating pathways of the cell cycle, such as a deregulated cyclin-dependent kinase (Cdk) activity and/or Cdk expression. Appropriately radiolabeled Cdk4 inhibitors are discussed as promising molecular probes for imaging cell proliferation processes and tumor visualization by PET. This work describes the design, synthesis and radiopharmacological evaluation of two 124I-labeled Cdk4 inhibitors as potential radiotracers for imaging of Cdk4 in vivo. Treatment of a solution containing labeling precursors with [124I]NaI gave radiolabeled Cdk4 inhibitors [124I]CKIA and [124I]CKIB in radiochemical yields of up to 35%. 124I-labeled radiotracers [124I]CKIA and [124I]CKIB were used in cell uptake studies as well as biodistribution studies in Wistar rats and small-animal PET in tumor-bearing mice. In vitro radiotracer uptake studies in adherent tumor cells using [124I]CKIA showed substantial uptake in HT-29 and FaDu cells (750–850 %ID/mg protein [124I]CKIA and 900–1000 %ID/mg protein [124I]CKIB) after 1 h at 37 °C. Biodistribution of [124I]CKIA and [124I]CKIB showed rapid blood clearance of radioactivity and an accumulation as well as metabolization in the liver. Both radiotracers were administered intravenously to mouse FaDu xenograft tumor model and imaging studies were performed on a small-animal PET scanner. Both imaging techniques showed only little uptake of both radiotracers in the FaDu tumor xenografts." @default.
• W2083337020 created "2016-06-24" @default.
• W2083337020 creator A5037270424 @default.
• W2083337020 creator A5048636639 @default.
• W2083337020 creator A5069240957 @default.
• W2083337020 creator A5076006857 @default.
• W2083337020 creator A5081387229 @default.
• W2083337020 creator A5086741053 @default.
• W2083337020 date "2010-02-01" @default.
• W2083337020 modified "2023-10-18" @default.
• W2083337020 title "Radiosynthesis and radiopharmacological evaluation of cyclin-dependent kinase 4 (Cdk4) inhibitors" @default.
• W2083337020 cites W1969255091 @default.
• W2083337020 cites W1969355167 @default.
• W2083337020 cites W1972523362 @default.
• W2083337020 cites W1974746050 @default.
• W2083337020 cites W1978985435 @default.
• W2083337020 cites W1980731475 @default.
• W2083337020 cites W1980755021 @default.
• W2083337020 cites W1985075123 @default.
• W2083337020 cites W1987373394 @default.
• W2083337020 cites W1990212809 @default.
• W2083337020 cites W1991054314 @default.
• W2083337020 cites W1993054739 @default.
• W2083337020 cites W2000254449 @default.
• W2083337020 cites W2000477606 @default.
• W2083337020 cites W2011207690 @default.
• W2083337020 cites W2024680115 @default.
• W2083337020 cites W2027558915 @default.
• W2083337020 cites W2029080338 @default.
• W2083337020 cites W2039771541 @default.
• W2083337020 cites W2042541486 @default.
• W2083337020 cites W2043761487 @default.
• W2083337020 cites W2049571523 @default.
• W2083337020 cites W2056920933 @default.
• W2083337020 cites W2061158845 @default.
• W2083337020 cites W2064991546 @default.
• W2083337020 cites W2066288792 @default.
• W2083337020 cites W2075066807 @default.
• W2083337020 cites W2075152619 @default.
• W2083337020 cites W2089528428 @default.
• W2083337020 cites W2095048284 @default.
• W2083337020 cites W2102942479 @default.
• W2083337020 cites W2109064685 @default.
• W2083337020 cites W2109458089 @default.
• W2083337020 cites W2111420633 @default.
• W2083337020 cites W2113604152 @default.
• W2083337020 cites W2147454124 @default.
• W2083337020 cites W2149658883 @default.
• W2083337020 cites W2154626333 @default.
• W2083337020 cites W2165957980 @default.
• W2083337020 cites W2169927110 @default.
• W2083337020 cites W2178607918 @default.
• W2083337020 cites W339986449 @default.
• W2083337020 doi "https://doi.org/10.1016/j.ejmech.2009.11.020" @default.
• W2083337020 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19954867" @default.
• W2083337020 hasPublicationYear "2010" @default.
• W2083337020 type Work @default.
• W2083337020 sameAs 2083337020 @default.
• W2083337020 citedByCount "19" @default.
• W2083337020 countsByYear W20833370202012 @default.
• W2083337020 countsByYear W20833370202013 @default.
• W2083337020 countsByYear W20833370202014 @default.
• W2083337020 countsByYear W20833370202015 @default.
• W2083337020 countsByYear W20833370202016 @default.
• W2083337020 countsByYear W20833370202017 @default.
• W2083337020 countsByYear W20833370202019 @default.
• W2083337020 countsByYear W20833370202020 @default.
• W2083337020 countsByYear W20833370202021 @default.
• W2083337020 countsByYear W20833370202023 @default.
• W2083337020 crossrefType "journal-article" @default.
• W2083337020 hasAuthorship W2083337020A5037270424 @default.
• W2083337020 hasAuthorship W2083337020A5048636639 @default.
• W2083337020 hasAuthorship W2083337020A5069240957 @default.
• W2083337020 hasAuthorship W2083337020A5076006857 @default.
• W2083337020 hasAuthorship W2083337020A5081387229 @default.
• W2083337020 hasAuthorship W2083337020A5086741053 @default.
• W2083337020 hasConcept C124320809 @default.
• W2083337020 hasConcept C1491633281 @default.
• W2083337020 hasConcept C150903083 @default.
• W2083337020 hasConcept C185592680 @default.
• W2083337020 hasConcept C202751555 @default.
• W2083337020 hasConcept C207001950 @default.
• W2083337020 hasConcept C2776970183 @default.
• W2083337020 hasConcept C2777807558 @default.
• W2083337020 hasConcept C29537977 @default.
• W2083337020 hasConcept C502942594 @default.
• W2083337020 hasConcept C55493867 @default.
• W2083337020 hasConcept C86803240 @default.
• W2083337020 hasConceptScore W2083337020C124320809 @default.
• W2083337020 hasConceptScore W2083337020C1491633281 @default.
• W2083337020 hasConceptScore W2083337020C150903083 @default.
• W2083337020 hasConceptScore W2083337020C185592680 @default.
• W2083337020 hasConceptScore W2083337020C202751555 @default.
• W2083337020 hasConceptScore W2083337020C207001950 @default.
• W2083337020 hasConceptScore W2083337020C2776970183 @default.
• W2083337020 hasConceptScore W2083337020C2777807558 @default.
• W2083337020 hasConceptScore W2083337020C29537977 @default.
• W2083337020 hasConceptScore W2083337020C502942594 @default.

• next