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• W2083342685 abstract "Forty-eight heterocyclic amino acid trimers, analogues of distamycin, with a number of features that enhance lipophilicity are described. They contain alkyl or cycloalkyl groups larger than methyl; some are N-terminated by acetamide or methoxybenzamide and are C-terminated by dimethylaminopropyl or aliphatic heterocylic aminopropyl substituents. The ability of these compounds to bind principally to AT tracts of DNA has been evaluated using capillary zone electrophoresis. Significant antimicrobial activity against key organisms such as MRSA and Candida albicans is shown by several compounds, especially those containing a thiazole. Moreover, these compounds have low toxicity with respect to several mammalian cell lines." @default.
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• W2083342685 date "2004-03-05" @default.
• W2083342685 modified "2023-10-14" @default.
• W2083342685 title "Distamycin Analogues with Enhanced Lipophilicity: Synthesis and Antimicrobial Activity" @default.
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• W2083342685 doi "https://doi.org/10.1021/jm031089x" @default.
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