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- W2083343314 abstract "To determine the sites of positive feedback action of estrogen and progesterone (P), pituitary responsiveness to LHRH under estradiol benzoate (EB) and P influence was examined in the ovariectomized guinea pig. Two to 3 days before the experiment, animals received an implantation of an indwelling venous catheter for blood sampling (drawn every 15 min) and for LHRH administration. Plasma LH was measured by RIA. In the fust experiment, a single dose of LHRH (1.0μg) was given to five groups of animals: non-EB-treated; 12 h, 30 h, and 36 h after 1.5 μg EB; and 30 h after 1.5 μg EB plus 2 h after 0.5 μg P. Plasma LH levels were significantly elevated 15 min after LHRH injection in all treatments. In the subsequent 60-90 min, LH levels decreased exponentially. The peak value was highest in the group of non-EB-treated animals and diminished as time elapsed after EB treatment. P plus EB priming did not facilitate an LH response significantly greater than priming with EB alone. In the second experiment, LHRH was g..." @default.
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- W2083343314 date "1980-02-01" @default.
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- W2083343314 title "Influence of Ovarian Steroids on Pituitary Sensitivity to Luteinizing Hormone-Releasing Hormone in the Ovariectomized Guinea Pig*" @default.
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- W2083343314 doi "https://doi.org/10.1210/endo-106-2-425" @default.
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