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- W2083347589 abstract "1 . In isolated 5-hydroxytryptamine (5-HT) organelles of rabbit platelets, the concentrations of 5-HT, histamine and adenosinetriphosphate (ATP) respectively are about 200 times higher than in intact platelets. Organelles incubated in plasma at 37° C gradually lose endogenous 5-HT, histamine and ATP and take up 14C-5-HT against a considerable concentration gradient. Liberation and uptake of 5-HT markedly decrease with dimishing incubation temperature. 2 . Exposure to reserpine in vitro strongly counteracts the uptake of 14C-5-HT by isolated organelles, whereas the 14C-5-HT uptake of intact isolated platelets is less affected by the drug. 5-HT organelles of platelets from reserpinized rabbits also take up very little 14C-5-HT. 3 . Imipramine inhibits the uptake of 14C-5-HT in isolated organelles less markedly than in isolated platelets. 4 . It is concluded that in the organelles 5-HT and possibly histamine may be associated with ATP. Reserpine probably impairs the uptake of 5-HT at the level of the organelles (possibly by interfering with the association 5-HT/ATP), whereas imipramine seems to act preferentially on the cell membrane." @default.
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- W2083347589 date "1968-11-01" @default.
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- W2083347589 title "Isolated 5-hydroxytryptamine organelles of rabbit blood platelets: physiological properties and drug-induced changes" @default.
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- W2083347589 doi "https://doi.org/10.1111/j.1476-5381.1968.tb08487.x" @default.
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