FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083350128> ?p ?o ?g. }

• W2083350128 endingPage "185" @default.
• W2083350128 startingPage "175" @default.
• W2083350128 abstract "Hox proteins are among the most intensively studied transcription factors and represent key factors in establishing morphological differences along the anterior–posterior axis of animals. They are generally regarded as highly conserved in function, a view predominantly based on experiments comparing a few (anterior) Hox proteins. However, the extent to which central or abdominal Hox proteins share conserved functions and sequence signatures remains largely unexplored. To shed light on the functional divergence of the central Hox proteins, we present an easy to use resource aimed at predicting the functional similarities of central Hox proteins using sequence elements known to be relevant to Hox protein functions. We provide this resource both as a stand-alone download, including all information, as well as via a simplified web-interface that facilitates an accurate and fine-tuned annotation of novel Hox sequences. The method used in the manuscript is, so far, the only published sequence-based method capable of differentiating between the functionally distinct central Hox proteins with near-identical homeodomains (such as the Drosophila Antp, Ubx and Abd-A Hox proteins). In this manuscript, a pairwise-sequence-similarity based approach (using the bioinformatics tool CLANS) is used to analyze all available central Hox protein sequences. The results are combined with a large-scale species phylogeny to depict the presence/absence of central Hox sequence-types across the bilaterian lineage. The obtained pattern of distribution of the Hox sequence-types throughout the species tree enables us to infer at which branching point a specific type of central Hox protein was present. Based on the Hox sequences currently available in public databases, seven sequence-similarity groups could be identified for the central Hox proteins, two of which have never been described before (Echi/Hemi7 and Echi/Hemi8). Our work also shows, for the first time, that Antp/Hox7-like sequences are present throughout all bilaterian clades and that all other central Hox protein groups are specific to sub-lineages in the protostome or deuterostome branches only." @default.
• W2083350128 created "2016-06-24" @default.
• W2083350128 creator A5022821072 @default.
• W2083350128 creator A5024631305 @default.
• W2083350128 creator A5049522616 @default.
• W2083350128 creator A5057298253 @default.
• W2083350128 creator A5065144850 @default.
• W2083350128 creator A5070639633 @default.
• W2083350128 date "2013-11-01" @default.
• W2083350128 modified "2023-09-27" @default.
• W2083350128 title "Analysis of central Hox protein types across bilaterian clades: On the diversification of central Hox proteins from an Antennapedia/Hox7-like protein" @default.
• W2083350128 cites W1518589663 @default.
• W2083350128 cites W1561007704 @default.
• W2083350128 cites W1579045133 @default.
• W2083350128 cites W1582956895 @default.
• W2083350128 cites W159147729 @default.
• W2083350128 cites W1599391997 @default.
• W2083350128 cites W1886964711 @default.
• W2083350128 cites W1965369504 @default.
• W2083350128 cites W1968199051 @default.
• W2083350128 cites W1970007988 @default.
• W2083350128 cites W1970549648 @default.
• W2083350128 cites W1975245492 @default.
• W2083350128 cites W1982226598 @default.
• W2083350128 cites W1983198039 @default.
• W2083350128 cites W1985348819 @default.
• W2083350128 cites W1995267165 @default.
• W2083350128 cites W2002383724 @default.
• W2083350128 cites W2004469286 @default.
• W2083350128 cites W2006788765 @default.
• W2083350128 cites W2034728925 @default.
• W2083350128 cites W2038890085 @default.
• W2083350128 cites W2042170348 @default.
• W2083350128 cites W2044718587 @default.
• W2083350128 cites W2049589779 @default.
• W2083350128 cites W2076621420 @default.
• W2083350128 cites W2084221802 @default.
• W2083350128 cites W2096641211 @default.
• W2083350128 cites W2101306722 @default.
• W2083350128 cites W2111568092 @default.
• W2083350128 cites W2113097498 @default.
• W2083350128 cites W2113561798 @default.
• W2083350128 cites W2116847895 @default.
• W2083350128 cites W2118615111 @default.
• W2083350128 cites W2122468638 @default.
• W2083350128 cites W2127677836 @default.
• W2083350128 cites W2132926880 @default.
• W2083350128 cites W2133625266 @default.
• W2083350128 cites W2135056966 @default.
• W2083350128 cites W2138872556 @default.
• W2083350128 cites W2151364836 @default.
• W2083350128 cites W2151546179 @default.
• W2083350128 cites W2151831732 @default.
• W2083350128 cites W2153998712 @default.
• W2083350128 cites W2158564117 @default.
• W2083350128 cites W2158714788 @default.
• W2083350128 cites W2160125070 @default.
• W2083350128 cites W2165457864 @default.
• W2083350128 cites W2166755632 @default.
• W2083350128 doi "https://doi.org/10.1016/j.ydbio.2013.09.009" @default.
• W2083350128 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24055174" @default.
• W2083350128 hasPublicationYear "2013" @default.
• W2083350128 type Work @default.
• W2083350128 sameAs 2083350128 @default.
• W2083350128 citedByCount "10" @default.
• W2083350128 countsByYear W20833501282015 @default.
• W2083350128 countsByYear W20833501282016 @default.
• W2083350128 countsByYear W20833501282018 @default.
• W2083350128 countsByYear W20833501282019 @default.
• W2083350128 countsByYear W20833501282020 @default.
• W2083350128 countsByYear W20833501282021 @default.
• W2083350128 countsByYear W20833501282022 @default.
• W2083350128 crossrefType "journal-article" @default.
• W2083350128 hasAuthorship W2083350128A5022821072 @default.
• W2083350128 hasAuthorship W2083350128A5024631305 @default.
• W2083350128 hasAuthorship W2083350128A5049522616 @default.
• W2083350128 hasAuthorship W2083350128A5057298253 @default.
• W2083350128 hasAuthorship W2083350128A5065144850 @default.
• W2083350128 hasAuthorship W2083350128A5070639633 @default.
• W2083350128 hasBestOaLocation W20833501281 @default.
• W2083350128 hasConcept C104317684 @default.
• W2083350128 hasConcept C111039654 @default.
• W2083350128 hasConcept C121587040 @default.
• W2083350128 hasConcept C167625842 @default.
• W2083350128 hasConcept C197564579 @default.
• W2083350128 hasConcept C199216141 @default.
• W2083350128 hasConcept C2777738586 @default.
• W2083350128 hasConcept C2780172944 @default.
• W2083350128 hasConcept C45484198 @default.
• W2083350128 hasConcept C54355233 @default.
• W2083350128 hasConcept C70721500 @default.
• W2083350128 hasConcept C78458016 @default.
• W2083350128 hasConcept C86339819 @default.
• W2083350128 hasConcept C86803240 @default.
• W2083350128 hasConcept C90132467 @default.
• W2083350128 hasConceptScore W2083350128C104317684 @default.
• W2083350128 hasConceptScore W2083350128C111039654 @default.
• W2083350128 hasConceptScore W2083350128C121587040 @default.

• next