Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083350900> ?p ?o ?g. }
- W2083350900 endingPage "86" @default.
- W2083350900 startingPage "72" @default.
- W2083350900 abstract "This study evaluates the use of the TGF-β receptor 1 inhibitor LY-364947 (LY) to prevent proliferative vitreoretinopathy (PVR). For the in vitro experiments Human Tenon's Fibroblasts (HTFs) and retinal pigment epithelial (RPE) cells were treated with different concentrations of LY to determine HTF proliferation and RPE transdifferentiation. For in vivo testing 30 rabbits underwent a PVR trauma model. The animals received different concentrations of intravitreally injected LY, with or without vitrectomy. LY treatment reduced HTF proliferation and RPE transdifferentiation in vitro. In vivo intravitreal injection of LY prevented PVR development significantly. This positive effect was also present when LY injection was combined with vitrectomy. Intravitreal injection of LY prevented tractional retinal detachment in 14 out of 15 animals. In conclusion, treatment with the TGF-β receptor 1 inhibitor LY reduces HTF proliferation and RPE transdifferentiation in vitro and prevents proliferative vitreoretinopathy and subsequent tractional retinal detachment in vivo." @default.
- W2083350900 created "2016-06-24" @default.
- W2083350900 creator A5020684039 @default.
- W2083350900 creator A5044037873 @default.
- W2083350900 creator A5046332320 @default.
- W2083350900 creator A5052392472 @default.
- W2083350900 creator A5056050665 @default.
- W2083350900 creator A5085689520 @default.
- W2083350900 creator A5087979687 @default.
- W2083350900 date "2014-06-01" @default.
- W2083350900 modified "2023-10-03" @default.
- W2083350900 title "A TGF-β receptor 1 inhibitor for prevention of proliferative vitreoretinopathy" @default.
- W2083350900 cites W1548538594 @default.
- W2083350900 cites W1967886231 @default.
- W2083350900 cites W1968762000 @default.
- W2083350900 cites W1971515439 @default.
- W2083350900 cites W1973321912 @default.
- W2083350900 cites W1977837623 @default.
- W2083350900 cites W1978391747 @default.
- W2083350900 cites W1980325398 @default.
- W2083350900 cites W1981158116 @default.
- W2083350900 cites W1989857510 @default.
- W2083350900 cites W2004690419 @default.
- W2083350900 cites W2008659893 @default.
- W2083350900 cites W2009051009 @default.
- W2083350900 cites W2009292000 @default.
- W2083350900 cites W2009959180 @default.
- W2083350900 cites W2012673473 @default.
- W2083350900 cites W2014091044 @default.
- W2083350900 cites W2018311573 @default.
- W2083350900 cites W2019938767 @default.
- W2083350900 cites W2023999968 @default.
- W2083350900 cites W2028064396 @default.
- W2083350900 cites W2033767541 @default.
- W2083350900 cites W2034152019 @default.
- W2083350900 cites W2036938077 @default.
- W2083350900 cites W2037510839 @default.
- W2083350900 cites W2039275948 @default.
- W2083350900 cites W2039299132 @default.
- W2083350900 cites W2041879303 @default.
- W2083350900 cites W2043877024 @default.
- W2083350900 cites W2044600667 @default.
- W2083350900 cites W2044709783 @default.
- W2083350900 cites W2045731328 @default.
- W2083350900 cites W2052147002 @default.
- W2083350900 cites W2054784074 @default.
- W2083350900 cites W2055164201 @default.
- W2083350900 cites W2058426336 @default.
- W2083350900 cites W2063091279 @default.
- W2083350900 cites W2065790323 @default.
- W2083350900 cites W2067238776 @default.
- W2083350900 cites W2068583228 @default.
- W2083350900 cites W2071787763 @default.
- W2083350900 cites W2072198264 @default.
- W2083350900 cites W2074020261 @default.
- W2083350900 cites W2080517676 @default.
- W2083350900 cites W2084775283 @default.
- W2083350900 cites W2087692391 @default.
- W2083350900 cites W2090893538 @default.
- W2083350900 cites W2091561756 @default.
- W2083350900 cites W2091918502 @default.
- W2083350900 cites W2096712640 @default.
- W2083350900 cites W2103031848 @default.
- W2083350900 cites W2108491787 @default.
- W2083350900 cites W2112691507 @default.
- W2083350900 cites W2128507281 @default.
- W2083350900 cites W2130541610 @default.
- W2083350900 cites W2132215341 @default.
- W2083350900 cites W2134690686 @default.
- W2083350900 cites W2137218119 @default.
- W2083350900 cites W2146755607 @default.
- W2083350900 cites W2152875073 @default.
- W2083350900 cites W2167516593 @default.
- W2083350900 cites W2319601936 @default.
- W2083350900 cites W2327719224 @default.
- W2083350900 cites W2335187016 @default.
- W2083350900 doi "https://doi.org/10.1016/j.exer.2014.04.006" @default.
- W2083350900 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24742493" @default.
- W2083350900 hasPublicationYear "2014" @default.
- W2083350900 type Work @default.
- W2083350900 sameAs 2083350900 @default.
- W2083350900 citedByCount "34" @default.
- W2083350900 countsByYear W20833509002016 @default.
- W2083350900 countsByYear W20833509002017 @default.
- W2083350900 countsByYear W20833509002018 @default.
- W2083350900 countsByYear W20833509002019 @default.
- W2083350900 countsByYear W20833509002020 @default.
- W2083350900 countsByYear W20833509002021 @default.
- W2083350900 countsByYear W20833509002022 @default.
- W2083350900 countsByYear W20833509002023 @default.
- W2083350900 crossrefType "journal-article" @default.
- W2083350900 hasAuthorship W2083350900A5020684039 @default.
- W2083350900 hasAuthorship W2083350900A5044037873 @default.
- W2083350900 hasAuthorship W2083350900A5046332320 @default.
- W2083350900 hasAuthorship W2083350900A5052392472 @default.
- W2083350900 hasAuthorship W2083350900A5056050665 @default.
- W2083350900 hasAuthorship W2083350900A5085689520 @default.
- W2083350900 hasAuthorship W2083350900A5087979687 @default.