FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083351146> ?p ?o ?g. }

• W2083351146 endingPage "2717" @default.
• W2083351146 startingPage "2709" @default.
• W2083351146 abstract "Pseudoxanthoma elasticum (PXE), a rare recessive genetic disease causing skin, eye, and cardiovascular lesions, is characterized by the calcification of elastic fibers. The disorder is due to loss-of-function mutations of the ABCC6 gene, but the pathophysiology of the disease is still not understood. Here we investigated the transcriptional regulation of the gene, using DNase I hypersensitivity assay followed by luciferase reporter gene assay. We identified three DNase I hypersensitive sites (HSs) specific to cell lines expressing ABCC6. These HSs are located in the proximal promoter and in the first intron of the gene. We further characterized the role of the HSs by luciferase assay and demonstrated the transcriptional activity of the intronic HS. We identified the CCAAT/enhancer-binding protein β (C/EBPβ) as a factor binding the second intronic HS by chromatin immunoprecipitation and corroborated this finding by luciferase assays. We also showed that C/EBPβ interacts with the proximal promoter of the gene. We propose that C/EBPβ forms a complex with other regulatory proteins including the previously identified regulatory factor hepatocyte nuclear factor 4α (HNF4α). This complex would account for the tissue-specific expression of the gene and might serve as a metabolic sensor. Our results point toward a better understanding of the physiological role of ABCC6." @default.
• W2083351146 created "2016-06-24" @default.
• W2083351146 creator A5019643252 @default.
• W2083351146 creator A5021040068 @default.
• W2083351146 creator A5027057915 @default.
• W2083351146 creator A5033639753 @default.
• W2083351146 creator A5041466906 @default.
• W2083351146 creator A5060913161 @default.
• W2083351146 creator A5082759449 @default.
• W2083351146 creator A5083294960 @default.
• W2083351146 date "2012-12-01" @default.
• W2083351146 modified "2023-10-16" @default.
• W2083351146 title "ABCC6 Expression Is Regulated by CCAAT/Enhancer-Binding Protein Activating a Primate-Specific Sequence Located in the First Intron of the Gene" @default.
• W2083351146 cites W1496990746 @default.
• W2083351146 cites W1586509612 @default.
• W2083351146 cites W1605020879 @default.
• W2083351146 cites W179818011 @default.
• W2083351146 cites W1964282225 @default.
• W2083351146 cites W1977595014 @default.
• W2083351146 cites W1979079687 @default.
• W2083351146 cites W1982732183 @default.
• W2083351146 cites W1983792126 @default.
• W2083351146 cites W1984561224 @default.
• W2083351146 cites W1990082393 @default.
• W2083351146 cites W1997211111 @default.
• W2083351146 cites W1997403604 @default.
• W2083351146 cites W1998470916 @default.
• W2083351146 cites W2001568974 @default.
• W2083351146 cites W2004117462 @default.
• W2083351146 cites W2016959636 @default.
• W2083351146 cites W2021481602 @default.
• W2083351146 cites W2031236163 @default.
• W2083351146 cites W2036458282 @default.
• W2083351146 cites W2037718729 @default.
• W2083351146 cites W2039307052 @default.
• W2083351146 cites W2045101444 @default.
• W2083351146 cites W2050322944 @default.
• W2083351146 cites W2051657789 @default.
• W2083351146 cites W2052120983 @default.
• W2083351146 cites W2065865989 @default.
• W2083351146 cites W2066466374 @default.
• W2083351146 cites W2071949994 @default.
• W2083351146 cites W2077260227 @default.
• W2083351146 cites W2081173141 @default.
• W2083351146 cites W2084422700 @default.
• W2083351146 cites W2084608963 @default.
• W2083351146 cites W2089793634 @default.
• W2083351146 cites W2090919618 @default.
• W2083351146 cites W2095005830 @default.
• W2083351146 cites W2096572854 @default.
• W2083351146 cites W2104142691 @default.
• W2083351146 cites W2108998829 @default.
• W2083351146 cites W2123505868 @default.
• W2083351146 cites W2123769115 @default.
• W2083351146 cites W2128016314 @default.
• W2083351146 cites W2129011493 @default.
• W2083351146 cites W2131213389 @default.
• W2083351146 cites W2148984020 @default.
• W2083351146 cites W2158761669 @default.
• W2083351146 cites W2160320288 @default.
• W2083351146 cites W2163785860 @default.
• W2083351146 cites W2404082640 @default.
• W2083351146 doi "https://doi.org/10.1038/jid.2012.218" @default.
• W2083351146 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3509247" @default.
• W2083351146 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22763786" @default.
• W2083351146 hasPublicationYear "2012" @default.
• W2083351146 type Work @default.
• W2083351146 sameAs 2083351146 @default.
• W2083351146 citedByCount "14" @default.
• W2083351146 countsByYear W20833511462012 @default.
• W2083351146 countsByYear W20833511462013 @default.
• W2083351146 countsByYear W20833511462015 @default.
• W2083351146 countsByYear W20833511462016 @default.
• W2083351146 countsByYear W20833511462017 @default.
• W2083351146 countsByYear W20833511462018 @default.
• W2083351146 countsByYear W20833511462020 @default.
• W2083351146 countsByYear W20833511462022 @default.
• W2083351146 crossrefType "journal-article" @default.
• W2083351146 hasAuthorship W2083351146A5019643252 @default.
• W2083351146 hasAuthorship W2083351146A5021040068 @default.
• W2083351146 hasAuthorship W2083351146A5027057915 @default.
• W2083351146 hasAuthorship W2083351146A5033639753 @default.
• W2083351146 hasAuthorship W2083351146A5041466906 @default.
• W2083351146 hasAuthorship W2083351146A5060913161 @default.
• W2083351146 hasAuthorship W2083351146A5082759449 @default.
• W2083351146 hasAuthorship W2083351146A5083294960 @default.
• W2083351146 hasBestOaLocation W20833511461 @default.
• W2083351146 hasConcept C101762097 @default.
• W2083351146 hasConcept C104317684 @default.
• W2083351146 hasConcept C111335760 @default.
• W2083351146 hasConcept C111936080 @default.
• W2083351146 hasConcept C134320426 @default.
• W2083351146 hasConcept C149240914 @default.
• W2083351146 hasConcept C150194340 @default.
• W2083351146 hasConcept C153911025 @default.
• W2083351146 hasConcept C165864922 @default.
• W2083351146 hasConcept C21592294 @default.
• W2083351146 hasConcept C29512474 @default.

• next