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- W2083353265 abstract "Cytotoxic chemotherapy prolongs survival of patients with advanced and metastatic tumors. This is, however, a double-edged sword with many adverse effects. Since the liver has a rich blood supply and plays an active role in the metabolism of medications, it is not surprising that there can be hepatic injury related to chemotherapy. In addition, radioembolization may affect the parenchyma of normal and cirrhotic livers. We review chemotherapy-associated liver injury in patients with colorectal liver metastases, including downsizing chemotherapy and neoadjuvant chemotherapy. We discuss the mechanism of the hepatic injury, secondary to reactive oxygen species, and the spectrum of hepatic injury including, steatosis, steatohepatitis, hepatic sinusoidal injury and highlight the pharmacogenomics of such liver insults. Methods for reducing and treating the hepatotoxicity are discussed for specific agents including tamxifen and the newly introduced targeted antibodies." @default.
- W2083353265 created "2016-06-24" @default.
- W2083353265 creator A5044034778 @default.
- W2083353265 creator A5073034256 @default.
- W2083353265 date "2013-01-01" @default.
- W2083353265 modified "2023-10-02" @default.
- W2083353265 title "Liver Injury Induced by Anticancer Chemotherapy and Radiation Therapy" @default.
- W2083353265 cites W1520918055 @default.
- W2083353265 cites W1604798497 @default.
- W2083353265 cites W1860868308 @default.
- W2083353265 cites W1967173495 @default.
- W2083353265 cites W1969529822 @default.
- W2083353265 cites W1973662511 @default.
- W2083353265 cites W1975010709 @default.
- W2083353265 cites W1975281579 @default.
- W2083353265 cites W1975798481 @default.
- W2083353265 cites W1980377648 @default.
- W2083353265 cites W1984101482 @default.
- W2083353265 cites W1985941484 @default.
- W2083353265 cites W1986588288 @default.
- W2083353265 cites W1989053425 @default.
- W2083353265 cites W1990295946 @default.
- W2083353265 cites W1993166310 @default.
- W2083353265 cites W1995277697 @default.
- W2083353265 cites W1995301618 @default.
- W2083353265 cites W1995944130 @default.
- W2083353265 cites W1996775250 @default.
- W2083353265 cites W1998417832 @default.
- W2083353265 cites W1999048513 @default.
- W2083353265 cites W2004016630 @default.
- W2083353265 cites W2005839262 @default.
- W2083353265 cites W2008082672 @default.
- W2083353265 cites W2028456177 @default.
- W2083353265 cites W2030214589 @default.
- W2083353265 cites W2031436799 @default.
- W2083353265 cites W2031811526 @default.
- W2083353265 cites W2037122471 @default.
- W2083353265 cites W2039142311 @default.
- W2083353265 cites W2039603705 @default.
- W2083353265 cites W2046843883 @default.
- W2083353265 cites W2048775722 @default.
- W2083353265 cites W2051842222 @default.
- W2083353265 cites W2054895270 @default.
- W2083353265 cites W2058402035 @default.
- W2083353265 cites W2063931196 @default.
- W2083353265 cites W2066593706 @default.
- W2083353265 cites W2066596712 @default.
- W2083353265 cites W2069660570 @default.
- W2083353265 cites W2076645058 @default.
- W2083353265 cites W2078345568 @default.
- W2083353265 cites W2080120151 @default.
- W2083353265 cites W2084893146 @default.
- W2083353265 cites W2085773264 @default.
- W2083353265 cites W2090865105 @default.
- W2083353265 cites W2092270700 @default.
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- W2083353265 cites W2095826876 @default.
- W2083353265 cites W2096029667 @default.
- W2083353265 cites W2096078008 @default.
- W2083353265 cites W2097212177 @default.
- W2083353265 cites W2109653150 @default.
- W2083353265 cites W2114090139 @default.
- W2083353265 cites W2115375080 @default.
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- W2083353265 cites W2120268483 @default.
- W2083353265 cites W2122712927 @default.
- W2083353265 cites W2123363005 @default.
- W2083353265 cites W2131745440 @default.
- W2083353265 cites W2134371395 @default.
- W2083353265 cites W2134876369 @default.
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- W2083353265 cites W2155330904 @default.
- W2083353265 cites W2161339168 @default.
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- W2083353265 doi "https://doi.org/10.1155/2013/815105" @default.
- W2083353265 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3732607" @default.
- W2083353265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23970972" @default.
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