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- W2083359657 abstract "Diabetic patients show a higher likelihood of developing heart failure (HF), independently of the atherosclerotic process, than their nondiabetic counterparts. This suggests the presence of an intrinsic vulnerability of the heart in patients with diabetes mellitus.A cardiomyopathy specific to the diabetic patient was first hypothesized by Rubler and co-workers, in 1972 and recognized as a nosologic entity by the World Health Organization (WHO) in 1995. All patients falling under Rubler's definition had ascertained diabetic glomerusclerosis, but were unaffected by major coronary artery disease (CAD). Notably, the mean plasma glucose in those patients was 417 ± 209 mg/dl. Since then, several studies conducted in both animals and in humans have focused on pathogenetic mechanisms, clinical manifestations, diagnostic as well as therapeutic approaches utilized for the treatment of diabetic cardiomyopathy (DCM). Despite the large body of literature available, the clinical entity and significance of this diabetic complication continue to be elusive.In the present report, recent pathophysiological findings and diagnostic strategies to treat DCM are reviewed. Particular attention is dedicated to the clinical manifestation of DCM, that is to heart failure (HF), and to the implications of co-morbidities and metabolic control on its evolution." @default.
- W2083359657 created "2016-06-24" @default.
- W2083359657 creator A5029164653 @default.
- W2083359657 creator A5079605815 @default.
- W2083359657 date "2013-07-01" @default.
- W2083359657 modified "2023-09-25" @default.
- W2083359657 title "The limited clinical value of a specific diabetic cardiomyopathy" @default.
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- W2083359657 doi "https://doi.org/10.1016/j.numecd.2013.03.008" @default.
- W2083359657 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23725770" @default.
- W2083359657 hasPublicationYear "2013" @default.
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