Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083365888> ?p ?o ?g. }
- W2083365888 endingPage "e57513" @default.
- W2083365888 startingPage "e57513" @default.
- W2083365888 abstract "Hepcidin regulation by competing stimuli such as infection and iron deficiency has not been studied in infants and it's yet unknown whether hepcidin regulatory pathways are fully functional in infants. In this cross-sectional study including 339 Kenyan infants aged 6.0±1.1 months (mean±SD), we assessed serum hepcidin-25, biomarkers of iron status and inflammation, and fecal calprotectin. Prevalence of inflammation, anemia, and iron deficiency was 31%, 71%, 26%, respectively. Geometric mean (±SD) serum hepcidin was 6.0 (±3.4) ng/mL, and was significantly lower in males than females. Inflammation (C-reactive protein and interleukin-6) and iron status (serum ferritin, zinc protoporphyrin and soluble transferrin receptor) were significant predictors of serum hepcidin, explaining nearly 60% of its variance. There were small, but significant differences in serum hepcidin comparing iron deficient anemic (IDA) infants without inflammation to iron-deficient anemic infants with inflammation (1.2 (±4.9) vs. 3.4 (±4.9) ng/mL; P<0.001). Fecal calprotectin correlated with blood/mucus in the stool but not with hepcidin. Similarly, the gut-linked cytokines IL-12 and IL-17 did not correlate with hepcidin. We conclude that hepcidin regulatory pathways are already functional in infancy, but serum hepcidin alone may not clearly discriminate between iron-deficient anemic infants with and without infection. We propose gender-specific reference values for serum hepcidin in iron-replete infants without inflammation." @default.
- W2083365888 created "2016-06-24" @default.
- W2083365888 creator A5005121617 @default.
- W2083365888 creator A5014567834 @default.
- W2083365888 creator A5024638194 @default.
- W2083365888 creator A5037651451 @default.
- W2083365888 creator A5039156935 @default.
- W2083365888 creator A5039257474 @default.
- W2083365888 creator A5050980380 @default.
- W2083365888 creator A5052693979 @default.
- W2083365888 creator A5081089994 @default.
- W2083365888 date "2013-02-27" @default.
- W2083365888 modified "2023-09-29" @default.
- W2083365888 title "Iron Status and Systemic Inflammation, but Not Gut Inflammation, Strongly Predict Gender-Specific Concentrations of Serum Hepcidin in Infants in Rural Kenya" @default.
- W2083365888 cites W110272686 @default.
- W2083365888 cites W1914990933 @default.
- W2083365888 cites W1974888851 @default.
- W2083365888 cites W1977915178 @default.
- W2083365888 cites W1981807290 @default.
- W2083365888 cites W1996469113 @default.
- W2083365888 cites W1996687642 @default.
- W2083365888 cites W2003339005 @default.
- W2083365888 cites W2027624389 @default.
- W2083365888 cites W2028598756 @default.
- W2083365888 cites W2029637725 @default.
- W2083365888 cites W2032865199 @default.
- W2083365888 cites W2035079086 @default.
- W2083365888 cites W2049537480 @default.
- W2083365888 cites W2049603148 @default.
- W2083365888 cites W2049912996 @default.
- W2083365888 cites W2061035099 @default.
- W2083365888 cites W2068234766 @default.
- W2083365888 cites W2072993305 @default.
- W2083365888 cites W2078721513 @default.
- W2083365888 cites W2089815078 @default.
- W2083365888 cites W2097119026 @default.
- W2083365888 cites W2106977301 @default.
- W2083365888 cites W2109945939 @default.
- W2083365888 cites W2132437552 @default.
- W2083365888 cites W2133714715 @default.
- W2083365888 cites W2138295023 @default.
- W2083365888 cites W2141337211 @default.
- W2083365888 cites W2141826373 @default.
- W2083365888 cites W2144753011 @default.
- W2083365888 cites W2145859184 @default.
- W2083365888 cites W2145935108 @default.
- W2083365888 cites W2148251643 @default.
- W2083365888 cites W2156493547 @default.
- W2083365888 cites W2158002180 @default.
- W2083365888 cites W2161998284 @default.
- W2083365888 cites W2163311416 @default.
- W2083365888 cites W2170375210 @default.
- W2083365888 cites W4249150518 @default.
- W2083365888 doi "https://doi.org/10.1371/journal.pone.0057513" @default.
- W2083365888 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3583867" @default.
- W2083365888 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23460869" @default.
- W2083365888 hasPublicationYear "2013" @default.
- W2083365888 type Work @default.
- W2083365888 sameAs 2083365888 @default.
- W2083365888 citedByCount "48" @default.
- W2083365888 countsByYear W20833658882013 @default.
- W2083365888 countsByYear W20833658882014 @default.
- W2083365888 countsByYear W20833658882015 @default.
- W2083365888 countsByYear W20833658882016 @default.
- W2083365888 countsByYear W20833658882017 @default.
- W2083365888 countsByYear W20833658882018 @default.
- W2083365888 countsByYear W20833658882019 @default.
- W2083365888 countsByYear W20833658882020 @default.
- W2083365888 countsByYear W20833658882021 @default.
- W2083365888 countsByYear W20833658882022 @default.
- W2083365888 countsByYear W20833658882023 @default.
- W2083365888 crossrefType "journal-article" @default.
- W2083365888 hasAuthorship W2083365888A5005121617 @default.
- W2083365888 hasAuthorship W2083365888A5014567834 @default.
- W2083365888 hasAuthorship W2083365888A5024638194 @default.
- W2083365888 hasAuthorship W2083365888A5037651451 @default.
- W2083365888 hasAuthorship W2083365888A5039156935 @default.
- W2083365888 hasAuthorship W2083365888A5039257474 @default.
- W2083365888 hasAuthorship W2083365888A5050980380 @default.
- W2083365888 hasAuthorship W2083365888A5052693979 @default.
- W2083365888 hasAuthorship W2083365888A5081089994 @default.
- W2083365888 hasBestOaLocation W20833658881 @default.
- W2083365888 hasConcept C126322002 @default.
- W2083365888 hasConcept C134018914 @default.
- W2083365888 hasConcept C203014093 @default.
- W2083365888 hasConcept C2776252253 @default.
- W2083365888 hasConcept C2776710925 @default.
- W2083365888 hasConcept C2776732101 @default.
- W2083365888 hasConcept C2776768029 @default.
- W2083365888 hasConcept C2776914184 @default.
- W2083365888 hasConcept C2777417653 @default.
- W2083365888 hasConcept C2778248108 @default.
- W2083365888 hasConcept C2778260677 @default.
- W2083365888 hasConcept C2778292693 @default.
- W2083365888 hasConcept C2778319317 @default.
- W2083365888 hasConcept C2779134260 @default.
- W2083365888 hasConcept C2779875672 @default.
- W2083365888 hasConcept C42407357 @default.