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- W2083368658 abstract "Abstract Selective serotonin reuptake inhibitors (SSRIs) are increasingly used to treat a variety of disorders but have gastrointestinal side‐effects. Aim: To determine the effects of the SSRI, fluoxetine, on gastric smooth muscle contractility. Methods: Fundic, antral, and pyloric circular muscle contractility of guinea pig muscle strips were measured in vitro . Fluoxetine was added in concentrations from 0.1 nmol L −1 to 100 μ mol L −1 . Receptor antagonists were used to determine the neural pathways involved. Results: Fluoxetine caused concentration dependent contractions, which were greatest in fundus compared with the antrum or pylorus. The contractile effects of fluoxetine in the antrum were reduced by tetrodotoxin, atropine, phentolamine, and the 5‐HT 4 receptor antagonist GR 113808. The contractile effects of fluoxetine in the fundus were reduced by atropine, phentolamine, and GR 113808. Conclusions: Fluoxetine affects gastric contractility with regional variability – contracting the fundus more than the antrum or pylorus. The fluoxetine contractile effect is reduced by tetrodotoxin, atropine, phentolamine, and a 5‐HT 4 receptor antagonist. These results suggest fluoxetine interacts with muscarinic, alpha‐adrenergic, and serotoninergic receptors and/or ongoing reuptake/release of serotonin in the stomach." @default.
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- W2083368658 date "2005-01-04" @default.
- W2083368658 modified "2023-10-12" @default.
- W2083368658 title "Effects of the selective serotonin reuptake inhibitor, fluoxetine, on regional gastric contractility1" @default.
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- W2083368658 doi "https://doi.org/10.1111/j.1365-2982.2004.00613.x" @default.
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