FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083375319> ?p ?o ?g. }

• W2083375319 endingPage "400" @default.
• W2083375319 startingPage "391" @default.
• W2083375319 abstract "There is evidence that polychlorinated biphenyl (PCB) congeners with ortho chlorine substituents have potential to cause neurotoxicity. Many PCB congeners implicated in these neurotoxic effects are chiral. It is currently unknown if the enantiomers of chiral PCB congeners have different neurotoxic effects. We herein report the effect of racemic 2,2',3,3',6-pentachlorobiphenyl (PCB 84) and its enantiomers on two neurochemical measures, protein kinase C (PKC) translocation as determined by [3H]-phorobol ester binding in cerebellar granule cells and Ca2+-sequestration as determined by 45Ca2+-uptake by microsomes isolated from adult rat cerebellum. Both (+)- and (-)-PCB 84 increased [3H]-phorobol ester binding in a concentration-dependent manner with (-)-PCB 84 being slightly more potent. Racemic PCB 84 was significantly more potent and efficacious than the pure enantiomers alone. (-)- and (+)-PCB 84 each inhibited microsomal 45Ca2+-uptake to a similar extent, whereas racemic PCB 84 was more potent and efficacious. These results indicate that PCB 84 enantiomers alone can have different potencies, and these may differ from that of the racemic mixture, observations that may have important implications for understanding the mechanisms of neurotoxicity of chiral PCB congeners." @default.
• W2083375319 created "2016-06-24" @default.
• W2083375319 creator A5024042726 @default.
• W2083375319 creator A5062746470 @default.
• W2083375319 creator A5065258484 @default.
• W2083375319 creator A5083956354 @default.
• W2083375319 date "2005-04-01" @default.
• W2083375319 modified "2023-10-03" @default.
• W2083375319 title "Effects of PCB 84 enantiomers on [3H]-phorbol ester binding in rat cerebellar granule cells and 45Ca2+-uptake in rat cerebellum" @default.
• W2083375319 cites W1539133138 @default.
• W2083375319 cites W1562796888 @default.
• W2083375319 cites W1775749144 @default.
• W2083375319 cites W1964094062 @default.
• W2083375319 cites W1966243944 @default.
• W2083375319 cites W1972516199 @default.
• W2083375319 cites W1975695296 @default.
• W2083375319 cites W1977405333 @default.
• W2083375319 cites W1983232677 @default.
• W2083375319 cites W1985697110 @default.
• W2083375319 cites W1987049748 @default.
• W2083375319 cites W1993676648 @default.
• W2083375319 cites W1995304428 @default.
• W2083375319 cites W1996140321 @default.
• W2083375319 cites W2000078485 @default.
• W2083375319 cites W2003403763 @default.
• W2083375319 cites W2016877073 @default.
• W2083375319 cites W2024219755 @default.
• W2083375319 cites W2029299793 @default.
• W2083375319 cites W2042268520 @default.
• W2083375319 cites W2045528608 @default.
• W2083375319 cites W2045807655 @default.
• W2083375319 cites W2055502971 @default.
• W2083375319 cites W2057576320 @default.
• W2083375319 cites W2057877784 @default.
• W2083375319 cites W2129031038 @default.
• W2083375319 cites W2132751187 @default.
• W2083375319 cites W2147215268 @default.
• W2083375319 cites W2151340945 @default.
• W2083375319 cites W2158615675 @default.
• W2083375319 cites W2168289137 @default.
• W2083375319 cites W2315281423 @default.
• W2083375319 cites W4293247451 @default.
• W2083375319 doi "https://doi.org/10.1016/j.toxlet.2004.12.011" @default.
• W2083375319 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15763638" @default.
• W2083375319 hasPublicationYear "2005" @default.
• W2083375319 type Work @default.
• W2083375319 sameAs 2083375319 @default.
• W2083375319 citedByCount "59" @default.
• W2083375319 countsByYear W20833753192012 @default.
• W2083375319 countsByYear W20833753192013 @default.
• W2083375319 countsByYear W20833753192014 @default.
• W2083375319 countsByYear W20833753192015 @default.
• W2083375319 countsByYear W20833753192016 @default.
• W2083375319 countsByYear W20833753192017 @default.
• W2083375319 countsByYear W20833753192018 @default.
• W2083375319 countsByYear W20833753192019 @default.
• W2083375319 countsByYear W20833753192021 @default.
• W2083375319 countsByYear W20833753192022 @default.
• W2083375319 crossrefType "journal-article" @default.
• W2083375319 hasAuthorship W2083375319A5024042726 @default.
• W2083375319 hasAuthorship W2083375319A5062746470 @default.
• W2083375319 hasAuthorship W2083375319A5065258484 @default.
• W2083375319 hasAuthorship W2083375319A5083956354 @default.
• W2083375319 hasConcept C107872376 @default.
• W2083375319 hasConcept C134018914 @default.
• W2083375319 hasConcept C151730666 @default.
• W2083375319 hasConcept C178790620 @default.
• W2083375319 hasConcept C181199279 @default.
• W2083375319 hasConcept C185592680 @default.
• W2083375319 hasConcept C25876315 @default.
• W2083375319 hasConcept C2776365360 @default.
• W2083375319 hasConcept C2779491297 @default.
• W2083375319 hasConcept C2779652256 @default.
• W2083375319 hasConcept C29730261 @default.
• W2083375319 hasConcept C486523 @default.
• W2083375319 hasConcept C49760210 @default.
• W2083375319 hasConcept C55493867 @default.
• W2083375319 hasConcept C71240020 @default.
• W2083375319 hasConcept C86803240 @default.
• W2083375319 hasConcept C87644729 @default.
• W2083375319 hasConcept C98274493 @default.
• W2083375319 hasConceptScore W2083375319C107872376 @default.
• W2083375319 hasConceptScore W2083375319C134018914 @default.
• W2083375319 hasConceptScore W2083375319C151730666 @default.
• W2083375319 hasConceptScore W2083375319C178790620 @default.
• W2083375319 hasConceptScore W2083375319C181199279 @default.
• W2083375319 hasConceptScore W2083375319C185592680 @default.
• W2083375319 hasConceptScore W2083375319C25876315 @default.
• W2083375319 hasConceptScore W2083375319C2776365360 @default.
• W2083375319 hasConceptScore W2083375319C2779491297 @default.
• W2083375319 hasConceptScore W2083375319C2779652256 @default.
• W2083375319 hasConceptScore W2083375319C29730261 @default.
• W2083375319 hasConceptScore W2083375319C486523 @default.
• W2083375319 hasConceptScore W2083375319C49760210 @default.
• W2083375319 hasConceptScore W2083375319C55493867 @default.
• W2083375319 hasConceptScore W2083375319C71240020 @default.
• W2083375319 hasConceptScore W2083375319C86803240 @default.
• W2083375319 hasConceptScore W2083375319C87644729 @default.

• next