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- W2083382016 abstract "A series of amides of caffeic acid were synthesized and evaluated for their anti-platelet and anti-oxidative activities. N-(2-Bromo-phenyl)-3-(3,4-dihydroxy-phenyl)-acrylamide (12) and N-(3-Bromo-phenyl)-3-(3,4-dihydroxy-phenyl)-acrylamide (13) exhibited potent inhibitory activity (IC(50)=5.8 and 6.7 microM, respectively) against arachidonic acid-induced (AA) platelet aggregation, comparable with invalid caffeic acid. Most of the synthesized caffeic acid anilides exhibited the promising anti-platelet aggregation in AA-induced assay and anti-oxidative activities. This study also exhibited that caffeic anilides displayed more potent anti-oxidative activity in the radical scavenging activity assay than trolox and vitamin E." @default.
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- W2083382016 date "2005-03-01" @default.
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- W2083382016 title "Evaluation of caffeic acid amide analogues as anti-platelet aggregation and anti-oxidative agents" @default.
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- W2083382016 doi "https://doi.org/10.1016/j.bmc.2004.11.055" @default.
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