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• W2083399552 abstract "The role of somatostatin analogues in the medical management of insulinomas is unclear. We describe an elderly patient with clinical and biochemical features of endogenous hyperinsulinism attributable to a benign islet B cell disorder whose incapacitating neuroglycopaenic symptoms responded dramatically to octreotide 50 micrograms subcutaneously at 2200 h each night. Octreotide suppressed inappropriate plasma concentrations of insulin thereby preventing fasting hypoglycaemia. Fasting concentrations of proinsulin, and 32-33 split proinsulin, as determined by two-site monoclonal antibody-based immunoradiometric assays, were also suppressed by octreotide." @default.
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• W2083399552 date "1993-09-01" @default.
• W2083399552 modified "2023-10-10" @default.
• W2083399552 title "Effects of octreotide on circulating islet B cell products in endogenous hyperinsulinism" @default.
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• W2083399552 doi "https://doi.org/10.1136/pgmj.69.815.735" @default.
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