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- W2083402821 abstract "Abstract Quantifying biomarkers related to tissues commonly injured in occupational settings may be useful for exposure assessment or predicting injury risk. Here, serum levels of Cartilage Oligomeric Matrix Protein (COMP), Interleukin-6 (IL6), and Creatine Kinase (CK) were obtained before and after participants completed a repetitive lumbar flexion/extension task. The task was done for one hour, using five combinations of external load and frequency. COMP levels did not change over time or between exposure conditions. IL6 levels were significantly affected by time and by external load, while CK levels were significantly affected by the load × frequency interaction. Greater external load and frequency (for CK only) resulted in greater peak values of IL6 and CK, and both biomarkers recovered by 24 h after task completion. Since IL6 and CK levels exhibited a dose–response relationship to exposure levels, they may have potential use in the occupational domain. Relevance to industry This study investigated the effects of external load and frequency, during repetitive lumbar flexion/extension, on biomarkers that reflect tissue injury. Responses of biomarkers related to muscle use and damage (IL6 and CK) support earlier epidemiological evidence, and these may have future value in predicting occupational injury risk." @default.
- W2083402821 created "2016-06-24" @default.
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- W2083402821 date "2015-07-01" @default.
- W2083402821 modified "2023-09-26" @default.
- W2083402821 title "Responsiveness of selected biomarkers of tissue damage to external load and frequency during repetitive lumbar flexion/extension" @default.
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- W2083402821 doi "https://doi.org/10.1016/j.ergon.2015.03.001" @default.
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