Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083403208> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2083403208 endingPage "739" @default.
- W2083403208 startingPage "734" @default.
- W2083403208 abstract "The phenobarbitone (PB) responsiveness of the 5'-proximal region of the CYP2B1/B2 gene was examined in detail with plasmid DNA constructs containing G-free cassette as reporter, using in vivo targeting of the same DNA constructs into rat liver as galactosylated-polylysine complexes. The contribution of the proximal region (-1 to -179 bp) and the positive element (-69 to -98 bp) identified earlier in this laboratory to PB responsiveness was assessed. The results obtained on PB treatment of rats subjected to receptor-mediated gene delivery to liver were conclusive and dramatic, with the control (saline-treated) rats manifesting very little expression of the reporter, reflecting the in vivo picture of CYP2B1/B2 gene expression. The positive element conferred PB responsiveness to homologous and heterologous promoters. Deletion of the positive element led to elimination of PB response. The entire -179 bp region was significantly more effective in responding to PB treatment than the region up to -98 bp, both containing one copy of the positive element. Thus, the positive element and its flanking sequences in the 5'-proximal region are involved in conferring PB responsiveness to the CYP2B1/B2 gene." @default.
- W2083403208 created "2016-06-24" @default.
- W2083403208 creator A5001296368 @default.
- W2083403208 creator A5051418339 @default.
- W2083403208 creator A5056187770 @default.
- W2083403208 creator A5057627734 @default.
- W2083403208 creator A5066986660 @default.
- W2083403208 date "2000-02-01" @default.
- W2083403208 modified "2023-09-23" @default.
- W2083403208 title "Receptor-Mediated Gene Delivery Approach Demonstrates the Role of 5′-Proximal DNA Region in Conferring Phenobarbitone Responsiveness to CYP2B2 Gene in Rat Liver in Vivo" @default.
- W2083403208 cites W1503993161 @default.
- W2083403208 cites W1532432516 @default.
- W2083403208 cites W1592745274 @default.
- W2083403208 cites W1598477767 @default.
- W2083403208 cites W1616231405 @default.
- W2083403208 cites W1832083730 @default.
- W2083403208 cites W1990330754 @default.
- W2083403208 cites W2007522990 @default.
- W2083403208 cites W2008779719 @default.
- W2083403208 cites W2025063808 @default.
- W2083403208 cites W2041172482 @default.
- W2083403208 cites W2044639011 @default.
- W2083403208 cites W2050745292 @default.
- W2083403208 cites W2056458409 @default.
- W2083403208 cites W2056887187 @default.
- W2083403208 cites W2073043576 @default.
- W2083403208 cites W2077801336 @default.
- W2083403208 cites W2082199182 @default.
- W2083403208 cites W2085837116 @default.
- W2083403208 cites W2133867412 @default.
- W2083403208 doi "https://doi.org/10.1006/bbrc.2000.2203" @default.
- W2083403208 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10679274" @default.
- W2083403208 hasPublicationYear "2000" @default.
- W2083403208 type Work @default.
- W2083403208 sameAs 2083403208 @default.
- W2083403208 citedByCount "7" @default.
- W2083403208 crossrefType "journal-article" @default.
- W2083403208 hasAuthorship W2083403208A5001296368 @default.
- W2083403208 hasAuthorship W2083403208A5051418339 @default.
- W2083403208 hasAuthorship W2083403208A5056187770 @default.
- W2083403208 hasAuthorship W2083403208A5057627734 @default.
- W2083403208 hasAuthorship W2083403208A5066986660 @default.
- W2083403208 hasConcept C104317684 @default.
- W2083403208 hasConcept C150194340 @default.
- W2083403208 hasConcept C153911025 @default.
- W2083403208 hasConcept C161733203 @default.
- W2083403208 hasConcept C207001950 @default.
- W2083403208 hasConcept C22744801 @default.
- W2083403208 hasConcept C54355233 @default.
- W2083403208 hasConcept C552990157 @default.
- W2083403208 hasConcept C86803240 @default.
- W2083403208 hasConceptScore W2083403208C104317684 @default.
- W2083403208 hasConceptScore W2083403208C150194340 @default.
- W2083403208 hasConceptScore W2083403208C153911025 @default.
- W2083403208 hasConceptScore W2083403208C161733203 @default.
- W2083403208 hasConceptScore W2083403208C207001950 @default.
- W2083403208 hasConceptScore W2083403208C22744801 @default.
- W2083403208 hasConceptScore W2083403208C54355233 @default.
- W2083403208 hasConceptScore W2083403208C552990157 @default.
- W2083403208 hasConceptScore W2083403208C86803240 @default.
- W2083403208 hasFunder F4320320719 @default.
- W2083403208 hasFunder F4320320721 @default.
- W2083403208 hasIssue "3" @default.
- W2083403208 hasLocation W20834032081 @default.
- W2083403208 hasLocation W20834032082 @default.
- W2083403208 hasOpenAccess W2083403208 @default.
- W2083403208 hasPrimaryLocation W20834032081 @default.
- W2083403208 hasRelatedWork W106631345 @default.
- W2083403208 hasRelatedWork W1969661822 @default.
- W2083403208 hasRelatedWork W2009966535 @default.
- W2083403208 hasRelatedWork W2021208088 @default.
- W2083403208 hasRelatedWork W2034650928 @default.
- W2083403208 hasRelatedWork W2056022116 @default.
- W2083403208 hasRelatedWork W2056172754 @default.
- W2083403208 hasRelatedWork W2161722978 @default.
- W2083403208 hasRelatedWork W2369240737 @default.
- W2083403208 hasRelatedWork W2378271209 @default.
- W2083403208 hasVolume "268" @default.
- W2083403208 isParatext "false" @default.
- W2083403208 isRetracted "false" @default.
- W2083403208 magId "2083403208" @default.
- W2083403208 workType "article" @default.